A5053349306- Fatty Acid Research and Health
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Nutritional Studies and Diet
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Cholesterol and Lipid Metabolism
- Nutrition and Health in Aging
- Nutrition, Genetics, and Disease
- Lipid metabolism and disorders
- Lipid metabolism and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Birth, Development, and Health
- Atherosclerosis and Cardiovascular Diseases
- Muscle metabolism and nutrition
- Obesity, Physical Activity, Diet
- Genetics, Aging, and Longevity in Model Organisms
- Eicosanoids and Hypertension Pharmacology
- Retinoids in leukemia and cellular processes
- Diet, Metabolism, and Disease
- Regulation of Appetite and Obesity
- Frailty in Older Adults
University of Oslo
2016-2025
OsloMet – Oslo Metropolitan University
2011-2022
Oslo University Hospital
2022
Tine (Norway)
2022
UiT The Arctic University of Norway
2022
New York University Press
2011-2021
Domus Medica
2021
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2021
Cambridge University Press
2011-2021
Institutt for Eksperimentell Medisinsk Forskning
2017-2018
Abstract The purpose of the present study is to investigate effects krill oil and fish on serum lipids markers oxidative stress inflammation evaluate if different molecular forms, triacylglycerol phospholipids, omega‐3 polyunsaturated fatty acids (PUFAs) influence plasma level EPA DHA differently. One hundred thirteen subjects with normal or slightly elevated total blood cholesterol and/or triglyceride levels were randomized into three groups given either six capsules ( N = 36; 3.0 g/day, +...
Abstract Background Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric N ordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. Methods conducted a randomized dietary study lasting for 18–24 weeks individuals features syndrome (mean age 55 years, BMI 31.6 kg m −2 , 67% women). Altogether 309 were screened, 200 started intervention after 4‐week run‐in period, 96...
The nuclear receptor liver X (LXR) alpha, an important regulator of cholesterol and bile acid metabolism, was analyzed after insulin stimulation in vitro vivo. A time- dose-dependent increase LXRalpha steady-state mRNA level seen primary rat hepatocytes culture. maximal induction 10-fold obtained when were exposed to 400 nm for 24 h. Cycloheximide, a potent inhibitor protein synthesis, prevented expression by insulin, indicating that the is dependent on de novo synthesis proteins....
In a systematic search for peroxisome proliferator–activated receptor-γ (PPAR-γ) target genes, we identified S3-12 and perilipin as novel direct PPAR-γ genes. Together with adipophilin tail-interacting protein of 47 kDa, these genes are lipid droplet–associating proteins distinct expression pattern but overlapping in adipose tissue. The is tightly correlated to the activation adipocytes, promoter characterization revealed that promoters contain three one evolutionarily conserved PPAR...
Abstract Objective To determine if daily supplementation with cod liver oil, a low dose vitamin D supplement, in winter, prevents SARS-CoV-2 infection, serious covid-19, or other acute respiratory infections adults Norway. Design Quadruple blinded, randomised placebo controlled trial. Setting Norway, 10 November 2020 to 2 June 2021. Participants 34 601 (aged 18-75 years), not taking supplements. Intervention 5 mL/day of oil (10 µg D, n=17 278) (n=17 323) for up six months. Main outcome...
The insulin-responsive glucose transporter GLUT4 plays a crucial role in insulin-mediated facilitated uptake into adipose tissue and muscle, impaired expression of has been linked to obesity diabetes. In this study, we demonstrate that liver X receptors (LXRs) regulate the through direct interaction with conserved LXR response element promoter. WAT is induced by potent agonist wild type, LXRα-/-, LXRβ-/- mice but not LXRα-/-β-/- mice, demonstrating both LXRs are able mediate ligand activated...
The pivotal role of liver X receptors (LXRs) in the metabolic conversion cholesterol to bile acids mice is well established. More recently, LXRα promoter has been shown be under tight regulation by peroxisome proliferator-activated (PPARs), implying a for mediating interplay between and fatty acid metabolism. We have studied LXR fat cells demonstrate that regulated during adipogenesis augments accumulation mature adipocytes. expression murine 3T3-L1 adipocytes as human was up-regulated...
The adipose differentiation-related protein (ADFP)/adipophilin belongs to a family of PAT (for perilipin, ADFP, and TIP47) proteins that associate on the surface lipid droplets (LDs). Except for LD association, clear role ADFP has not been found. We demonstrate is transcriptionally regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) in mouse liver rat human hepatoma cells through highly conserved direct repeat-1(DR-1) element. Although mRNA increased synthetic PPARalpha...
Nonalcoholic fatty liver disease (NAFLD) is the most common in Western and non-Western countries, but its pathogenesis not fully understood.Based on role of nicotinamide phosphoribosyltransferase (NAMPT) fat glucose metabolism cell survival, we hypothesized a for NAMPT/visfatin NAFLD-related disease.We conducted clinical studies at referral medical center well-characterized NAFLD patients (n = 58) healthy controls 27). In addition performed experimental vitro hepatocytes.We examined 1)...
Intake of fish oil reduces the risk CHD and deaths. Marine n -3 fatty acids (FA) are susceptible to oxidation, but our knowledge, health effects intake oxidised have not previously been investigated in human subjects. The aim present study was investigate markers oxidative stress, lipid peroxidation inflammation, level plasma FA after oil. In a double-blinded randomised controlled study, healthy subjects (aged 18–50 years, 54) were assigned into one three groups receiving capsules containing...
Background While beneficial health effects of fish and oil consumption are well documented, the incorporation n-3 polyunsaturated fatty acids in plasma lipid classes is not completely understood. The aim this study was to investigate effect supplementation on lipidomic profile healthy subjects. Methodology/Principal Findings In a double-blinded randomized controlled parallel-group study, subjects received capsules containing either 8 g/d (FO) (1.6 EPA+DHA) (n = 16) or high oleic sunflower...
Abstract Branched-chain amino acids (BCAA) are essential that necessary for muscle mass maintenance. Little is known about the plasma concentrations of BCAA and protein intake in relation to sarcopenia. We aimed compare non-fasting dietary between sarcopenic non-sarcopenic older adults. Norwegian home-dwelling adults (≥70 years) were invited a cross-sectional study with no other exclusion criteria than age. Sarcopenic subjects defined by diagnostic European Working Group on Sarcopenia Older...
Abstract Background Low-grade, chronic inflammation during ageing, (“inflammageing”), is suggested to be involved in the development of frailty older age. However, studies on association between frailty, using index definition, and inflammatory markers are limited. The aim this study was investigate relationship (FI) older, home-dwelling adults. Method Home-dwelling men women aged ≥ 70 years old, living South-East Norway were recruited included a cross-sectional study. FI used current...
The concentration and the duration of exposure to low-density lipoprotein cholesterol (LDL-C) (LDL-C burden) is an important determinant risk for cardiovascular disease thresholds has recently been estimated. Individuals with familial hypercholesterolemia (FH) have increased premature disease. overall aim present study was describe differences in LDL-C level burden females males FH visiting outpatient lipid clinic from a young age, using multiple measurements during follow-up time 12 years....