A5101599590- Brucella: diagnosis, epidemiology, treatment
- Cutaneous Melanoma Detection and Management
- Monoclonal and Polyclonal Antibodies Research
- Nonmelanoma Skin Cancer Studies
- Burkholderia infections and melioidosis
- Galectins and Cancer Biology
- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Glycosylation and Glycoproteins Research
- Melanoma and MAPK Pathways
- Animal Disease Management and Epidemiology
- Bacteriophages and microbial interactions
- Cutaneous lymphoproliferative disorders research
- Skin Protection and Aging
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Microbial infections and disease research
- Cell Image Analysis Techniques
- Yersinia bacterium, plague, ectoparasites research
- Animal health and immunology
- Toxin Mechanisms and Immunotoxins
- Cancer and Skin Lesions
- AI in cancer detection
- Blood groups and transfusion
- Air Quality and Health Impacts
Skåne University Hospital
2016-2025
Lund University
2014-2025
Helsingborgs lasarett
2014-2025
Karolinska Institutet
2016
Medical University of Graz
2016
Karolinska University Hospital
2016
Canadian Food Inspection Agency
2002-2012
Austrian Society of Dermatology and Venereology
2009
Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias
2007
Universidad Autónoma de Nuevo León
2007
Deep learning convolutional neural networks (CNN) may facilitate melanoma detection, but data comparing a CNN's diagnostic performance to larger groups of dermatologists are lacking.Google's Inception v4 CNN architecture was trained and validated using dermoscopic images corresponding diagnoses. In comparative cross-sectional reader study 100-image test-set used (level-I: dermoscopy only; level-II: plus clinical information images). Main outcome measures were sensitivity, specificity area...
Melanoma is currently divided on a genetic level according to mutational status. However, this classification does not optimally predict prognosis. In prior studies, we have defined gene expression phenotypes (high-immune, pigmentation, proliferative and normal-like), which are predictive of survival outcome as well informative biology. Herein, employed population-based metastatic melanoma cohort external cohorts determine the prognostic significance phenotypes. We performed profiling 214...
Abstract Objective Women with active sunlight exposure habits experience a lower mortality rate than women who avoid sun exposure; however, they are at an increased risk of skin cancer. We aimed to explore the differences in main causes death according exposure. Methods assessed as factor for all‐cause competing scenario 29 518 Swedish prospective 20‐year follow‐up Melanoma Southern Sweden ( MISS ) cohort. were recruited from 1990 1992 (aged 25–64 years start study). obtained detailed...
BRAF and NRAS mutations are frequently found in melanoma tumours, recently developed BRAF-targeted therapies demonstrate significant clinical benefit.We sought to investigate the significance of a clinic-based metastatic cohort.In total, 237 mostly lesions, from 203 patients were screened for exon 15 2 using Sanger sequencing. mutation status was analysed relation histopathological characteristics, outcome.Mutation present 43% (88% V600E, 10% V600K) 30% (48% Q61K, 40% Q61R) melanomas,...
Sunlight exposure and fair skin are major determinants of human vitamin D production, but they also risk factors for cutaneous malignant melanoma (MM). There is epidemiological evidence that all-cause mortality related to low levels.We assessed the avoidance sun as a factor 29 518 Swedish women in prospective 20-year follow-up Melanoma Southern Sweden (MISS) cohort. Women were recruited from 1990 1992 aged 25 64 years at start study. We obtained detailed information baseline on their habits...
Immune checkpoint blockade (ICB) has improved outcome for patients with metastatic melanoma but not all benefit from treatment. Several immune- and tumor intrinsic features are associated clinical response at baseline. However, we need to further understand the molecular changes occurring during development of ICB resistance. Here, collect biopsies a cohort 44 after progression on anti-CTLA4 or anti-PD1 monotherapy. Genetic alterations antigen presentation interferon gamma signaling pathways...
Studies of the serum bactericidal system in bovine brucellosis were undertaken to investigate role humoral immune response protection cattle against facultative intracellular parasite Brucella abortus. Fresh sera from normal control cattle, infected and immunized with B. abortus cell envelopes collected before treatment during course immunization or infection. Normal fresh agammaglobulinemic colostrum-deprived calves was effective killing smooth virulent 2308, but rough strains RB51 (a...
Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based study including 40,000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression Stepwise Cox [SCR], hazard ratios [HRs] with 95% Confidence Intervals [CI]) relation to factors, age groups (older or younger than 40 years) primary site, analyzed. In 29,520 women complete follow-up...
Germline mutations in CDKN2A have been associated with increased risk of melanoma and tobacco-related cancers respiratory upper digestive tissues. In wild-type (wt) families, other known high-risk, melanoma-predisposing are rare, no has observed for nonskin this group. This study is the first to compare survival germline mutated (mut) nonmutated cases.Melanoma-prone families participating were identified through a nationwide predictive program starting 1987. Information on cancer diagnoses...
Abstract Background Melanoma is a type of superficial tumor. As advanced melanoma has poor prognosis, early detection and therapy are essential to reduce melanoma‐related deaths. To that end, there need develop quantitative method for diagnosing melanoma. This paper reports the development such diagnostic system using hyperspectral data (HSD) convolutional neural network, which machine learning. Materials Methods HSD were acquired imager, spectrometer can simultaneously capture information...
Basal cell carcinoma (BCC) is the most common skin cancer. Incidence largely unknown because of incomplete, or lack of, registration in countries.To assess current incidence rates and recent trends for BCC Swedish population.Patient- tumour-related features all histologically confirmed tumours diagnosed Sweden from 2004 to 2017 were extracted population-based Registry. standardized 2013 European Standard Population analysed using Poisson regression models.The age-standardized person-based...
The recommended treatment for cutaneous squamous cell carcinoma is surgical excision. An initial punch biopsy often performed as an aid to diagnosis. A retrospective registry-based study was assess histopathological concordance of and subsequent Analysis 737 biopsies matched excisions performed. In total, 493 (67%) lesions were confirmed invasive on excision, 76% when excluding "scar" a final Tumour diameter > 20mm highly predictive (positive value 91.1%). Tumours the scalp significantly...
Background: Teledermoscopy (TDS) emerges as an efficient tool for diagnosing skin lesions. In Sweden, double reading is the standard of care, but risk factors misdiagnosis or mismanagement using single reader evaluations (SRE) are not well-studied. This study aimed to assess accuracy SRE compared with gold in TDS. Methods: retrospective cohort involved 1,997 TDS referrals sent from general practitioners dermatologists Stockholm, selected based on dermoscopic diagnoses. All underwent (DRE)....
ABSTRACT Background Several widely used drugs have photosensitizing properties, and much research has been conducted to find associations between their use the risk of developing cutaneous malignant melanoma (cM), basal cell carcinoma (BCC) or squamous (cSCC), often with conflicting results. Objective To assess whether commonly prescribed increases skin cancer risk. Methods Analyses were performed using a large cohort women, prospectively collected information on phenotypic traits sun...
Prediction of the histopathological subtype basal cell carcinoma (BCC) is important for tailoring optimal treatment, especially in patients with suspected superficial BCC (sBCC).To assess accuracy preoperative prediction subtypes clinical practice, to evaluate whether dermoscopic examination enhances and find criteria discriminating sBCC from other subtypes.The main presurgical diagnosis was compared histopathological, postoperative routinely excised skin tumours a predominantly fair-skinned...
When used correctly, dermoscopy is an essential tool for helping clinicians in the diagnosis of skin diseases and early detection cancers. Despite its proven benefits, there a lack data about how European dermatologists use everyday practice.To identify motivations, obstacles modifiable factors influencing daily dermatology practice across Europe.All registered 32 countries were invited to complete online survey 20 questions regarding demographic characteristics, training self-confidence...
The presence of immune cells in the tumor microenvironment has been associated with response to immunotherapies across several cancer types, including melanoma. Despite its therapeutic relevance, characterization melanoma microenvironments remains insufficiently explored. To distinguish a cohort 180 metastatic clinical specimens, we developed method using promoter CpG methylation cell type-specific genes extracted from genome-wide arrays. Unsupervised clustering identified three clusters...