A5059690035- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Immunotherapy and Immune Responses
- Skin Protection and Aging
- Cancer Genomics and Diagnostics
- T-cell and B-cell Immunology
- Melanoma and MAPK Pathways
- melanin and skin pigmentation
- CAR-T cell therapy research
- Immune Response and Inflammation
- BRCA gene mutations in cancer
- Digital Imaging in Medicine
- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Genetic and rare skin diseases.
- RNA Interference and Gene Delivery
- Infectious Diseases and Mycology
- Medicine and Dermatology Studies History
- Dermatological diseases and infestations
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Allergic Rhinitis and Sensitization
- Hedgehog Signaling Pathway Studies
- Mast cells and histamine
Leiden University Medical Center
2015-2024
Leiden University
2011-2021
University of Naples Federico II
2016
University of Campania "Luigi Vanvitelli"
2016
Loyola University Medical Center
2015
Agendia (Netherlands)
2013
Amsterdam UMC Location Vrije Universiteit Amsterdam
2013
University Medical Center
2013
University Hospital and Clinics
2013
Netherlands Consortium for Healthy Ageing
2013
Mature dendritic cells (DCs) are believed to induce T cell immunity, whereas immature DCs tolerance. Here we describe that injections of matured with tumor necrosis factor (TNF)-α (TNF/DCs) antigen-specific protection from experimental autoimmune encephalomyelitis (EAE) in mice. Maturation by TNF-α induced high levels major histocompatibility complex class II and costimulatory molecules on DCs, but they remained weak producers proinflammatory cytokines. One injection such TNF/DCs pulsed...
Dendritic cells (DC) were cultured from mouse bone marrow (BM) progenitors in low concentrations of granulocyte-macrophage colony-stimulating factor (GM-CSF) (GMlo DC) by two different protocols. The phenotype and functional properties these GMlo DC compared to those standard BM-DC cultures generated high GM-CSF (GMhi or plus IL-4 (GMlo/IL-4 DC). An effect on maturation was observed only at but not doses GM-CSF. Compared mature DC, phenotypically immature, weak stimulators allogeneic...
Dendritic cells (DC) can be generated from mouse bone marrow (BM) in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF). Bacterial stimuli such as endotoxin / lipopolysaccharide (LPS) induce their final maturation. When BM-DC cultures were treated at day 6 or later with LPS, this maturation was induced vitro within 24 h. Such mature DC exhibited high levels surface MHC II molecules and potent T cell sensitizing, but reduced endocytosis capacity. In contrast, immature...
When used correctly, dermoscopy is an essential tool for helping clinicians in the diagnosis of skin diseases and early detection cancers. Despite its proven benefits, there a lack data about how European dermatologists use everyday practice.To identify motivations, obstacles modifiable factors influencing daily dermatology practice across Europe.All registered 32 countries were invited to complete online survey 20 questions regarding demographic characteristics, training self-confidence...
Abstract Background In Europe, one of the highest melanoma incidences is found in Netherlands. Like several other European countries, females are more prone to develop as compared males, although survival worse for men. Objective To identify clinicopathological gender‐related differences that may lead gender‐specific preventive measures. Methods Data from Dutch Nationwide Network and Registry Histopathology Cytopathology (PALGA) were retrieved patients with primary, cutaneous Netherlands...
Journal Article The impact of dermoscopy on the management pigmented lesions in everyday clinical practice general dermatologists: a prospective study Get access J.I. Van Der Rhee, Rhee Department Dermatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, Netherlands Jasper van der Rhee. E‐mail: j.i.van_der_rhee@lumc.nl Search for other works by this author on: Oxford Academic Google Scholar W. Bergman, Bergman N.A. Kukutsch British Volume 162, Issue 3, 1 March 2010, Pages...
Few studies have investigated the impact of dermoscopy on management relatives from melanoma families. The objective this study was to assess clinical diagnosis and decisions in high-risk familial patients. In a prospective 132 consecutive patients were recruited pigmented lesions clinic tertiary reference centre for melanoma. Dermatologists expert identified 49 suspicious recorded pre- post-dermoscopy diagnoses decisions. Dermoscopy performed 37% Two melanomas identified. did not influence...
Individuals with two red hair colour (RHC)-MC1R genetic variants have light skin and blond/reddish and, in comparison those without such alleles, are at an increased risk of developing melanoma. Our study investigated the association RHC Total Dermo-scopy Score (TDS), items that make up TDS, atypical naevi melanomas from high melanoma patients. Eight hundred seventy-six 21 were scored according to TDS system MC1R poly-morphisms determined. Analyses revealed several including pigment network,...
Background: Older people have the highest incidence of melanoma and population in most Western countries is ageing. We evaluated how gap survival between younger older patients has developed during past decades.Material methods: All diagnosed with cutaneous 1989 2015 (n = 84,827) were identified from Netherlands Cancer Registry. Elderly defined as aged ≥70 years. Differences patient tumor characteristics described, age-specific rates calculated, relative (RS) multivariable analyses...
Abstract Background Several smartphone applications (app) with an automated risk assessment claim to be able detect skin cancer at early stage. Various studies that have evaluated these apps showed mainly poor performance. However, all were done in patients and lesions selected by a specialist. Objectives To investigate the performance of app comparing its dermatologist participants. Methods Participants National Skin Cancer Day enrolled multicentre study. indicated participants analysed...
Abstract Background Dermoscopy is known to increase the diagnostic accuracy of pigmented skin lesions (PSLs) when used by trained professionals. The effect dermoscopy training on ability dermal therapists (DTs) has not been studied so far. Objectives This study aimed investigate whether DTs, in comparison with general practitioners (GPs), benefited from a programme including dermoscopy, both their differentiate between different forms PSL and assign correct therapeutic strategy. Methods In...
Skin self-examination can help patients who are at high risk for developing melanoma to become more involved in their own surveillance and treatment. This study examined the use of total body photography as an aid skin from patients' perspective. A 179 individuals had undergone (60.5% response rate) completed a self-reported questionnaire assessing frequency self-examination, perceived usefulness photography, variety potential demographic, clinical psychological factors. Only approximately...
Abstract Background Cutaneous melanoma (CM) is a multifactorial disease, with both environmental and genetic factors involved. The incidence of CM has risen rapidly during the last decades, making it growing public health problem. Objectives purpose this retrospective study was to compare survival data between two neighbouring countries, Belgium (BE) Netherlands (NL). Methods Data were collected by Belgian Cancer Registry (BCR) (NCR) from 1 January 2004 until 31 December 2016. Mucosal...
To the Editor: Approximately 10% of patients with cutaneous melanomas have a positive melanoma family history. Germline mutation CDKN2A gene is most common cause familial melanoma.1Read J. Wadt K.A.W. Hayward N.K. Melanoma genetics.J Med Genet. 2016; 53: 1-14https://doi.org/10.1136/jmedgenet-2015-103150Crossref PubMed Scopus (133) Google Scholar Mutation carriers lifetime risk approximately 70%, and many develop at younger age.2van der Rhee J.I. Krijnen P. Gruis N.A. et al.Clinical...