A5046656103- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Allergic Rhinitis and Sensitization
- CAR-T cell therapy research
- Breast Cancer Treatment Studies
- Immunotherapy and Immune Responses
- Breast Lesions and Carcinomas
- Cell Image Analysis Techniques
- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- Advanced Biosensing Techniques and Applications
- AI in cancer detection
- Cancer Immunotherapy and Biomarkers
- Nail Diseases and Treatments
- Cell Adhesion Molecules Research
- MRI in cancer diagnosis
- Hedgehog Signaling Pathway Studies
- Cancer Cells and Metastasis
- Sex and Gender in Healthcare
- Asthma and respiratory diseases
- Optical Coherence Tomography Applications
- Cancer Genomics and Diagnostics
Utrecht University
2019-2024
University Medical Center Utrecht
2013-2024
Royal Prince Alfred Hospital
2023-2024
Melanoma Institute Australia
2020-2023
The University of Sydney
2020-2023
Improvements in recurrence-free survival (RFS) were demonstrated two recent randomized trials for patients with sentinel node (SN)-negative stage IIB or IIC melanoma receiving adjuvant systemic therapy (pembrolizumab/nivolumab). However, adverse events also occurred. Accurate individualized prognostic estimates of RFS and overall (OS) would allow to more accurately weigh the risks benefits therapy. Since current American Joint Committee on Cancer eighth edition (AJCC-8) staging system...
Although the prognosis of patients with thin primary cutaneous melanomas (T1, ≤ 1.0 mm) is generally excellent, some develop recurrence. We sought to and validate a model predicting recurrences in melanomas.A Dutch population-based cohort (n = 25,930, development set) from an Australian melanoma treatment center 2,968, validation were analyzed (median follow-up 6.7 12.0 years, respectively). Multivariable Cox models generated for local, regional, distant recurrence-free survival (RFS)....
Importance The Melanoma Institute Australia (MIA) sentinel node (SN) metastasis risk calculator provides estimates of positivity for individual patients based on 6 standard clinicopathological parameters and the full 6-parameter model has been externally validated previously using US data. However, given its geographically widespread use, further validation is required to ensure applicability other populations. Objective To validate MIA SN increase precision by refinement 95% CIs. Design,...
<h3>Importance</h3> Although regression is commonly observed in cutaneous melanoma, it uncertain whether associated with patient prognosis. <h3>Objective</h3> To determine histologically confirmed was better or worse survival patients primary melanoma. <h3>Design, Setting, and Participants</h3> This cohort study analyzed data from 2 large cohorts of adults (one the Netherlands other Australia) proven, stage 1 primary, invasive melanoma known status treated between 2000 2014, median follow-up...
Over recent years, sentinel lymph node biopsy (SLNB) recommendations in guidelines for cutaneous melanoma have changed considerably. We aimed to assess trends enactment of SLNB evaluate what extent were adhered to, and identify clinical pathological determinants (non-)adherence. Clinicopathological data from the Dutch nationwide network registry histopathology cytopathology retrieved patients diagnosed with primary The Netherlands between 2003 2014. was analyzed per year. Multivariable...
Around 70% of cutaneous malignant melanomas (MMs) develop de novo, and small-diameter or 'tiny' lesions are expected to represent the earliest manifestation most MMs.To describe clinical, histopathological dermoscopic features tiny MMs, investigate impact imaging tools, including total body photography (TBP) sequential digital dermoscopy (SDDI) in their detection.Consecutive MMs diagnosed over 2 years a referral centre were retrospectively included. Tiny defined as with diameter ≤ 5 mm on...
Melanoma is one of the most rapidly increasing forms cancer worldwide. Most studies about survival among patients with melanoma consider only primary tumor and disregard potential effect multiple tumors. A better understanding prognosis important for patient counselling follow-up strategies.To describe epidemiologic features in from Netherlands.This retrospective, population-based cohort study included adults histologically proven, primary, invasive cutaneous Netherlands between January 1,...
Our aim was to investigate the role of melanoma subtype on survival and focus effects stratified by Breslow thickness ulceration status.Patients with cutaneous stage I, II, or III diagnosed between 2000 2014 were derived from Dutch Nationwide Pathology Registry overall data Netherlands Cancer Registry. Patients followed until 2018. Using multivariable Cox proportional hazards models, hazard ratios calculated for each subtype, per category status, adjusted age, sex, stage, localization.A...
The aim of this study was to describe the imaging features patients with invasive ductolobular carcinoma breast in comparison proportion lobular component.We retrospectively reviewed mammographic, sonographic and MRI records 113 proven diagnosed between January 2008 October 2012 according BI-RADS ® lexicon, correlated these component.At mammography most common finding (62.9%) for an irregular, spiculated isodense mass. On ultrasound irregular hypoechoic mass, margins posterior acoustic...
Abstract Background Desmoplastic melanoma (DM) is an uncommon type of melanoma. Two histological subtypes DM can be distinguished: pure and mixed (PDM MDM). We hypothesized that discrimination between these associated with sentinel lymph node biopsy (SLNB) status survival. Methods Clinicopathological data from PALGA, the Dutch Pathology Register were retrieved patients diagnosed in The Netherlands 2000 2014. Clinical pathological variables extracted pathology text files, including or...
Invasive breast cancer comprises a spectrum of histological changes with purely lobular on one side and ductal the other, many mixed lesions in between. In previous study, we showed that patients any percentage component at core needle biopsy, preoperative MRI leads to detection clinically relevant additional findings substantial patients, irrespective component. Detection small may however not be reproducible among pathologists. Loss membrane expression E-cadherin or p120 is useful...
Identification of sentinel node (SN) metastases can set the adjuvant systemic therapy indication for patients with stage III melanoma. Studies re-evaluating diagnosis initially positive SN biopsies are scarce.Dutch melanoma who underwent biopsy between 2003 and 2014 were selected from PALGA, Dutch Pathology Registry. Histopathological slides SN-positive retrieved review. A random sample was reassessed by an expert pathologist. Recurrence-free survival (RFS) misclassified (false-positive)...
To the Editor: Approximately 10% of patients with cutaneous melanomas have a positive melanoma family history. Germline mutation CDKN2A gene is most common cause familial melanoma.1Read J. Wadt K.A.W. Hayward N.K. Melanoma genetics.J Med Genet. 2016; 53: 1-14https://doi.org/10.1136/jmedgenet-2015-103150Crossref PubMed Scopus (133) Google Scholar Mutation carriers lifetime risk approximately 70%, and many develop at younger age.2van der Rhee J.I. Krijnen P. Gruis N.A. et al.Clinical...
Abstract Background Melanoma patients with intra‐nodal nevi (INN) and without melanoma metastasis in the sentinel lymph node biopsy (SLNB) are generally treated as negative SLNB. However, diagnosis of INN may be difficult nodal metastases falsely regarded INN. Objectives Our aim was to evaluate clinical significance SLNB primary cutaneous on a nationwide level The Netherlands by comparing survival between three groups: (INN group), (negative group) irrespective (positive group). Methods Data...
ABSTRACT Identification of sentinel node (SN) metastases can set the adjuvant systemic therapy indication for stage III melanoma patients. For IIIA patients, a 1.0 mm threshold largest SN tumour diameter is used. Therefore, uniform reproducible measurement its size crucial. At present, number deposits or their microanatomical sites are not part inclusion criteria treatment. The goal current study was to show examples difficulty measuring and teach how it should be measured. Histopathological...
Introduction Because of different therapeutic regimens for superficial and non-superficial basal cell carcinomas (BCCs), accurate histopathological examination a punch biopsy to determine its subtype is essential. The aim the current study was evaluate additional yield more extensive step-section method that standard histologic at 4 levels. Material methods Data this prospective obtained from Pathology department Dutch tertiary hospital. Biopsy specimens subsequent patients March 2019 June...