A5074190717- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Global Cancer Incidence and Screening
- Advanced Radiotherapy Techniques
- Management of metastatic bone disease
- Cancer survivorship and care
- Cancer Risks and Factors
- Medical Imaging Techniques and Applications
- Spine and Intervertebral Disc Pathology
- Colorectal Cancer Surgical Treatments
- Prostate Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Breast Implant and Reconstruction
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Health Systems, Economic Evaluations, Quality of Life
- Prostate Cancer Treatment and Research
- MRI in cancer diagnosis
- Spinal Fractures and Fixation Techniques
- Childhood Cancer Survivors' Quality of Life
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Cardiac Imaging and Diagnostics
- Cancer Treatment and Pharmacology
University Medical Center Utrecht
2016-2025
Utrecht University
2016-2025
The Netherlands Cancer Institute
2025
Heidelberg University
2011-2022
University Hospital Heidelberg
2011-2022
Washington University in St. Louis
2021
Centre Oscar Lambret
2018
National University of Singapore
2007-2016
National University Health System
2009-2016
NIHR Birmingham Liver Biomedical Research Unit
2016
Surgery of the primary tumor usually is not advised for patients with metastatic breast cancer at diagnosis because disease considered incurable. In this population-based study, we evaluate impact local surgery on survival diagnosis.We included all 300 recorded Geneva Cancer Registry between 1977 and 1996. We compared mortality risks from who had to those adjusted these other prognostic factors.Women complete excision negative surgical margins a 40% reduced risk death as result...
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic (officially declared on the March 11, 2020), and resulting measures, are impacting daily life medical management of breast cancer patients survivors. We evaluated to what extent these changes have affected quality life, physical, psychosocial well-being previously or currently being treated for cancer. Methods This study was conducted within a prospective, multicenter cohort survivors (Utrecht Multiple BREast intervention...
In hepatic (90)Y radioembolization, pretreatment (99m)Tc-macroaggregated albumin ((99m)Tc-MAA) nuclear imaging is used for lung shunt analysis, evaluation of extrahepatic deposition, and sometimes treatment planning, using a partition model. A high level agreement between (99m)Tc-MAA distribution final (90)Y-microsphere assumed. The aim this study was to investigate the value SPECT predict intrahepatic posttreatment distribution.Volumes interest (VOIs) were delineated on contrast-enhanced CT...
Background Although several deep learning (DL) calcium scoring methods have achieved excellent performance for specific CT protocols, their in a range of examination types is unknown. Purpose To evaluate the DL method automatic across wide and to investigate whether can adapt different examinations when representative images are added existing training data set. Materials Methods The study included 7240 participants who underwent various nonenhanced that heart: coronary artery (CAC) CT,...
The emergence of the precision medicine paradigm in oncology has led to increasing interest integration real-world data (RWD) into cancer clinical research. As sources evidence (RWE), such could potentially help address uncertainties that surround adoption novel anticancer therapies clinic following their investigation trials. At present, RWE-generating studies which investigate antitumour interventions seem primarily focus on collecting and analysing observational RWD, typically forgoing...
Purpose Male breast cancer is a rare disease with an incidence rate less than 1% of that female cancer. Given its low incidence, few studies have assessed risk and prognosis. Methods This population-based study, including 459,846 women 2,665 men diagnosed in Denmark, Finland, Geneva, Norway, Singapore, Sweden over the last 40 years, compares trends relative survival, excess mortality between sexes. Results World standardized rates were 66.7 per 10 5 person-years 0.40 men. Women at younger...
Two hospital-based breast cancer databases (University Malaya Medical Center, Malaysia [n = 1513] and National University Hospital, Singapore 2545]) were merged into a regional registry of patients diagnosed between 1990 2007. A review the data found 51% before age 50 years. 72% percent women Chinese followed by Malays (16%), Indians (8%), other races (4%). Median tumor size at presentation was 26 mm about 25% presented with TNM stage III or IV disease. Most tumors ductal histology (87%)....
An international research consortium has been formed to facilitate evidence-based introduction of MR-guided radiotherapy (MR-linac) and address how the MR-linac could be used achieve an optimized radiation treatment approach improve patients' survival, local regional tumor control, quality life. The present paper describes organizational structure clinical part consortium. Furthermore, it elucidates why collaboration on this large project is necessary a central data registry program will implemented.
Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with 1.5T diagnostic quality MRI an online adaptive workflow. A prospective international registry was established facilitate the evidence-based implementation of into clinical...
Randomised controlled trials are increasingly conducted as embedded, nested, or using cohorts routinely collected data, including registries, electronic health records, and administrative databases, to assess if participants eligible for the trial facilitate recruitment, deliver an embedded intervention, collect outcome a combination of these purposes. This report presents Consolidated Standards Reporting Trials (CONSORT) extension randomised data (CONSORT-ROUTINE). The was developed look at...
The pace of innovation in radiation oncology is high and the window opportunity for evaluation narrow. Financial incentives, industry pressure, patients' demand high-tech treatments have led to widespread implementation innovations before, or even without, robust evidence improved outcomes has been generated. standard phase I-IV framework drug not most efficient desirable assessment technological innovations. In order provide a methodology clinical radiotherapy, we adapted surgical IDEAL fit...
Randomized controlled trials are investigating the benefit of hepatic radioembolization added to systemic therapy in first- and second-line treatment patients with colorectal liver metastases (CRLM). Remarkably, administered activity may still be suboptimal, because a dose–response relationship has not been defined. The purpose this study was characterize between tumor-absorbed dose response after <sup>90</sup>Y for CRLM. <b>Methods:</b> Thirty unresectable chemorefractory CRLM were treated...
Pain response after conventional external beam radiation therapy (cRT) in patients with painful bone metastases is observed 60% to 70% of patients. The aim the VERTICAL trial was investigate whether stereotactic body (SBRT) improves pain response.This single-center, phase 2, randomized controlled conducted within PRESENT cohort, which consists referred for our tertiary center. Cohort participants who gave broad informed consent randomization were randomly assigned cRT or SBRT. Only...
Objective: The aim was to compare the (sentinel) lymph node detection rate of indocyanine green (ICG)-fluorescent imaging versus standard-of-care 99m Tc-nanocoilloid for sentinel (SLN)-mapping. Background: current gold standard axillary staging in patients with breast cancer is biopsy (SLNB) using radio-guided surgery radioisotope technetium ( Tc), sometimes combined blue dye. A promising alternative fluorescent ICG. Methods: In this noninferiority trial, we enrolled 102 consecutive invasive...
Abstract Stereotactic large‐core needle biopsy is increasingly applied for the diagnosis of nonpalpable breast disease. Our study examines whether this minimally invasive technique sufficiently accurate to replace surgical biopsy. In a prospective multicenter study, 973 consecutive women with 1,029 lesions were offered stereotactic 14‐gauge If yielded cancer, patient was therapeutic surgery. Surgical proposed in cases biopsies without malignancy. An expert panel reviewed all discrepancies...