A5040742979- Bladder and Urothelial Cancer Treatments
- Advanced Radiotherapy Techniques
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Urological Disorders and Treatments
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Effects of Radiation Exposure
- Cancer Immunotherapy and Biomarkers
- Radiation Dose and Imaging
- Cancer Treatment and Pharmacology
- Sarcoma Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Colorectal Cancer Surgical Treatments
- Head and Neck Surgical Oncology
- Cancer Research and Treatments
- Management of metastatic bone disease
- Brain Metastases and Treatment
- Head and Neck Cancer Studies
University of Pennsylvania
2016-2025
Elekta (United States)
2015-2025
Hospital of the University of Pennsylvania
2011-2024
Elekta (Sweden)
2020-2024
Elekta (Switzerland)
2013-2023
RTOG Foundation
2019
Philadelphia University
2011-2018
UPMC Hillman Cancer Center
2017
California University of Pennsylvania
2014
Pennsylvania Hospital
2012
Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with 1.5T diagnostic quality MRI an online adaptive workflow. A prospective international registry was established facilitate the evidence-based implementation of into clinical...
We conducted a phase I trial evaluating pembrolizumab+hypofractionated radiotherapy (HFRT) for patients with metastatic cancers.There were two strata (12 each): (i) NSCLC/melanoma progressing on prior anti-PD-1 therapy, (ii) other cancer types; anti-PD-1-naive. Patients received 6 cycles of pembrolizumab, starting 1 week before HFRT. had ≥2 lesions; only one was irradiated (8 Gy × 3 first half; 17 second half in each stratum) and the other(s) followed response.Of 24 patients, 20 (83%)...
Locoregional failure for patients with locally advanced bladder cancer (LABC) after radical cystectomy (RC) is common even chemotherapy and associated high morbidity mortality. Adjuvant radiotherapy (RT) can decrease locoregional but has not been studied in the era.To investigate if adjuvant sequential RT plus improve recurrence-free survival (LRFS) compared alone.A randomized phase 3 trial was opened to compare vs RC LABC, a third arm added later as 2 alone, an emerging standard. The...
BACKGROUND Clinical trials of radiation after radical cystectomy (RC) and chemotherapy for bladder cancer are in development, but inclusion stratification factors have not been clearly established. In this study, the authors evaluated refined a published risk locoregional failure (LF) by applying it to multicenter patient cohort. METHODS The original stratification, which was developed using single‐institution series, produced 3 subgroups with significantly different LF based on pathologic...
BACKGROUND The authors assessed whether proton beam therapy (PBT) for prostate cancer (PCa) was associated with differing toxicity compared intensity‐modulated radiation (IMRT) using case‐matched analysis. METHODS From 2010 to 2012, 394 patients who had localized PCa received 79.2 Gray (Gy) relative biologic effectiveness (RBE) delivered either PBT (181 patients) or IMRT (213 patients). Patients were on risk group, age, and prior gastrointestinal (GI) genitourinary (GU) disorders, resulting...
PurposeThis prospective study is, to our knowledge, the first report of daily adaptive radiation therapy (ART) for head and neck cancer (HNC) using a 1.5T magnetic resonance imaging-linear accelerator (MR-linac) with particular focus on safety feasibility dosimetric results an online rigid registration-based adapt position (ATP) workflow.Methods MaterialsTen patients HNC received ART 1.5T/7MV MR-linac, 6 ATP only 4 1 offline adapt-to-shape replan. Setup variability custom immobilization...
PurposeContouring Collaborative for Consensus in Radiation Oncology (C3RO) is a crowdsourced challenge engaging radiation oncologists across various expertise levels segmentation. An obstacle to artificial intelligence (AI) development the paucity of multiexpert datasets; consequently, we sought characterize whether aggregate segmentations generated from multiple nonexperts could meet or exceed recognized expert agreement.ApproachParticipants who contoured ≥1 region interest (ROI) breast,...
Introduction Diffusion-weighted imaging (DWI) on MRI-linear accelerator (MR-linac) systems can potentially be used for monitoring treatment response and adaptive radiotherapy in head neck cancers (HNC) but requires extensive validation. We performed technical validation to compare six total DWI sequences an MR-linac MR simulator (MR sim) patients, volunteers, phantoms. Methods Ten human papillomavirus-positive oropharyngeal cancer patients ten healthy volunteers underwent a 1.5T with three...
BACKGROUND Risk stratification is a major challenge in bladder cancer (BC), and biomarker needed. Multiple studies have reported the neutrophil‐to‐lymphocyte ratio (NLR) as promising candidate; however, these analyses methodological limitations. Therefore, authors performed category B study to test whether NLR prognostic for overall survival (OS) after curative treatment or predictive benefit from neoadjuvant chemotherapy (NAC). METHODS This an unplanned secondary analysis of SWOG 8710,...
Magnetic resonance (MR)-guided radiation therapy (MRgRT) is a new technique for treatment of localized prostate cancer (PCa). We report the 12-month outcomes first PCa patients treated within an international consortium (the MOMENTUM study) on 1.5T MR-Linac system with ultrahypofractionated therapy.Patients 5 × 7.25 Gy were identified. Prostate specific antigen-level, physician-reported toxicity (Common Terminology Criteria Adverse Events [CTCAE]), and patient-reported (Quality Life...
In 2018, the first online adaptive magnetic resonance (MR)-guided radiotherapy (MRgRT) system using a 1.5-T MR-equipped linear accelerator (1.5-T MR-Linac) was clinically introduced. This enables radiotherapy, in which radiation plan is adapted to size and shape changes of targets at each treatment session based on daily MR-visualized anatomy.
737 Background: Randomized trials comparing radical cystectomy (RC) and trimodality therapy (TMT) in muscle invasive bladder cancer (MIBC) have not been feasible. In 2023, Zlotta et al. published a retrospective multi-institutional analysis evaluating metastasis free survival (MFS) overall (OS) outcomes patients treated with RC or TMT. is generally considered the highest quality data available for this comparison, but results were presented using traditional frequentist statistics which can...
Background and Purpose: To detect changes in apparent diffusion coefficient (ADC) values during radiation therapy for biological image-guided adaptive therapy, the variability ADC must be characterized. We evaluated reproducibility of head neck cancers on a 1.5T MR-linac. Methods: 39 cancer patients (36 primary tumors, 55 lymph nodes) were imaged with echo-planar imaging diffusion-weighted MRI MR-linac at two time points before start therapy. Mean median volume measured each lesion. Absolute...