A5049952269- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Prostate Cancer Treatment and Research
- Advanced X-ray and CT Imaging
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Metastasis and carcinoma case studies
- Cutaneous Melanoma Detection and Management
- Lanthanide and Transition Metal Complexes
- Bladder and Urothelial Cancer Treatments
- Pulmonary Hypertension Research and Treatments
- Head and Neck Cancer Studies
- Cardiac Arrhythmias and Treatments
- Economic and Financial Impacts of Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Sexual Differentiation and Disorders
- Cardiac pacing and defibrillation studies
- Growth Hormone and Insulin-like Growth Factors
- Inflammatory Biomarkers in Disease Prognosis
- Radiation Dose and Imaging
- Atomic and Subatomic Physics Research
Institute of Cancer Research
2022-2024
Royal Marsden NHS Foundation Trust
2022-2024
Royal Marsden Hospital
2019-2024
Newcastle University
2013
South Tyneside and Sunderland NHS Foundation Trust
2012
Sunderland Royal Hospital
2011
In 2018, the first online adaptive magnetic resonance (MR)-guided radiotherapy (MRgRT) system using a 1.5-T MR-equipped linear accelerator (1.5-T MR-Linac) was clinically introduced. This enables radiotherapy, in which radiation plan is adapted to size and shape changes of targets at each treatment session based on daily MR-visualized anatomy.
Obesity has reached epidemic proportions in the developed world. The progression from obesity to diabetes mellitus type 2, via metabolic syndrome, is recognised, and significant associated increase risk of major human cancers acknowledged. We review molecular basis involvement morbidly high concentrations endogenous or therapeutic insulin insulin-like growth factors finally cancer. Epidemiological biochemical studies establish role hyperinsulinaemia cancer progression. Insulin-like factors,...
Background Ultra-hypofractionated radiotherapy (UHRT) is an effective treatment for localised prostate cancer with acceptable toxicity profile; boosting the visible intraprostatic tumour has been shown to improve biochemical disease-free survival no significant impact on genitourinary and gastrointestinal toxicity1,2. Methods HERMES a single centre non-comparative randomised phase II trial in men intermediate or lower high risk cancer. Patients were allocated (1:1) 36.25 Gray (Gy) 5...
Introduction We aimed to establish if stereotactic body radiotherapy the prostate can be delivered safely using reduced clinical target volume (CTV) planning (PTV) margins on 1.5T MR-Linac (MRL) (Elekta, Stockholm, Sweden), in absence of gating. Methods Cine images taken 3 orthogonal planes during delivery SBRT with 36.25 Gray (Gy) 5 fractions MRL were analysed. Using data from 20 patients, percentage (RT) time where position moved beyond 1, 2, 3, 4 and mm left-right (LR), superior-inferior...
HERMES is a phase II trial of MRI-guided daily-adaptive radiotherapy (MRIgART) randomising men with localised prostate cancer to either 2-fractions SBRT boost the tumour or 5-fraction SBRT. In context this highly innovative regime dose delivered must be carefully considered. The first ten patients recruited were analysed in order establish received by targets and organs at risk (OARS) intrafraction motion. A regression analysis was performed measure how volume air within rectum might further...
Distended rectums on pre-radiotherapy scans are historically associated with poorer outcomes in patients treated two-dimensional IGRT. Subsequently, strict rectal tolerances and preparation regimes were implemented. Contemporary IGRT, daily online registration to the prostate, corrects interfraction motion but intrafraction remains. We re-examine need for management strategies when using contemporary IGRT by quantifying volume its effect motion.
In this abstract we present our initial results from the validation of a respiratory correlated 4D MRI golden angle stack stars radial sequence prior to its clinical implementation and highlight potential experimental pitfalls avoid that may impact motion range estimations. Correct phantom set up reduced underestimations by 3%-18% for simulated waveforms considered. Larger discrepancies observed low amplitude which improved increasing number bins.
Respiratory correlated 4D-MRI has the potential to be a valuable tool in radiotherapy. This work aims optimise and validate golden angle stack of stars radial sequence for measuring respiratory motion abdominal organs. A 4D phantom is used compare against 4D-CT. For craniocaudal movement, underestimated but estimation improves non-axial acquisitions. could due alignment direction with cartesian phase encoding axial
Motivation: 4D-MRI could improve online MR-guided radiotherapy treatments on the MR-Linac, but long reconstruction times hinder clinical implementation. Goal(s): To reconstruct and evaluate respiratory-correlated time-resolved 4D-MRIs from different acquisitions. Approach: We reconstructed using XD-GRASP GRASP-Pro algorithms a protocol (stack-of-stars) new Cartesian spiral sequence. compared reconstructions regarding diaphragm motion. Results: Respiratory-resolved were under 4 minutes...
Advancements in radiotherapy technology now enable the delivery of ablative doses to targets upper urinary tract, including primary renal cell carcinoma (RCC) or tract urothelial carcinomas (UTUC), and secondary involvement by other histologies. Magnetic resonance imaging-guided linear accelerators (MR-Linacs) have shown promise further improve precision adaptability stereotactic body (SBRT).