Alison Tree
A5041059810- Prostate Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Genital Health and Disease
- Lung Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- MRI in cancer diagnosis
- Advances in Oncology and Radiotherapy
- Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Statistical Methods in Clinical Trials
- Management of metastatic bone disease
- Brain Metastases and Treatment
- Cancer, Lipids, and Metabolism
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Surgical Simulation and Training
- COVID-19 and healthcare impacts
Institute of Cancer Research
2016-2025
Royal Marsden Hospital
2016-2025
Royal Marsden NHS Foundation Trust
2016-2025
National Health Service
2017-2025
Cancer Research UK
2018-2024
Mount Vernon Cancer Centre
2024
Cambridge University Hospitals NHS Foundation Trust
2024
St Bartholomew's Hospital
2024
Amsterdam University Medical Centers
2023
University of Washington
2023
BackgroundLocalised prostate cancer is commonly treated with external-beam radiotherapy. Moderate hypofractionation has been shown to be non-inferior conventional fractionation. Ultra-hypofractionated stereotactic body radiotherapy would allow shorter treatment courses but could increase acute toxicity compared conventionally fractionated or moderately hypofractionated We report the findings from a randomised trial of standard-of-care versus five-fraction for low-risk intermediate-risk...
PurposeDuring a global pandemic, the benefit of routine visits and treatment patients with cancer must be weighed against risks to patients, staff, society. Prostate is one most common cancers radiation oncology departments treat, efficient resource utilization essential in setting pandemic. Herein, we aim establish recommendations framework by which evaluate prostate therapy management decisions.Methods MaterialsRadiation oncologists from United States Kingdom rapidly conducted systematic...
Whether stereotactic body radiotherapy (SBRT) is noninferior to conventionally or moderately hypofractionated regimens with respect biochemical clinical failure in patients localized prostate cancer unclear.
Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT postoperative after radical prostatectomy is unclear.
Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with 1.5T diagnostic quality MRI an online adaptive workflow. A prospective international registry was established facilitate the evidence-based implementation of into clinical...
There is currently significant interest in the potential benefits of combining radiation and immune checkpoint blockade (ICB) to stimulate both regional distant abscopal responses. In melanoma lung cancer, patients who have received therapy during ICB appear prolonged survival. The PLUMMB trial (Pembrolizumab Muscle-invasive/Metastatic Bladder cancer) (NCT02560636) a phase I study test tolerability combination weekly with pembrolizumab metastatic or locally advanced urothelial cancer...
IntroductionMR-guided adapted radiotherapy (MRgART) using a high field MR-linac has recently become available. We report the estimated delivered fractional dose of first five prostate cancer patients treated at our centre MRgART and compare this to C-Arm linac daily Image Guided Radiotherapy (IGRT).MethodsPatients were treatment plans shaped their anatomy. The treatments recalculated on an MR image acquired immediately prior delivery in order estimate dose. C-arm non-adapted VMAT same images...
Background and purposeOligometastatic prostate cancer is a new emerging treatment field with only few prospective randomized studies published so far. Despite the lack of strong level I evidence, metastasis-directed therapies (MDT) are widely used in clinical practice, mainly based on retrospective small phase 2 large difference across centers. Pending results ongoing trials, there clear need for more consistent indications radiotherapy practices.Material methodsA European Society...