A5060860935- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Radiopharmaceutical Chemistry and Applications
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Advances in Oncology and Radiotherapy
- Glioma Diagnosis and Treatment
- Nutrition and Health in Aging
- Management of metastatic bone disease
- Effects of Radiation Exposure
- Radiation Dose and Imaging
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Renal cell carcinoma treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Oral health in cancer treatment
- Cardiac Imaging and Diagnostics
- Ovarian cancer diagnosis and treatment
- Nonmelanoma Skin Cancer Studies
San Raffaele University of Rome
2013-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2016-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2024
Vita-Salute San Raffaele University
2016-2024
IRCCS Ospedale San Raffaele
2021-2024
The Christie NHS Foundation Trust
2013
KU Leuven
2013
Università Cattolica del Sacro Cuore
2013
Foundation Center
2009-2012
Introduction Chemoradiotherapy in head and neck cancer patients has a curative intent but often deteriorates nutritional status leading to sarcopenia cachexia. Methods In this observational single-centered study, prospective evaluation of several biochemical anthropometrical parameters, weight loss, handgrip strength, visual analogue scale appetite, questionnaires associated with malnutrition & quality life body composition (obtained by Bioelectrical Impedance Vector Analysis) was...
553 Background: There is limited data in the literature concerning management of patients (pts) with metachronous oligometastatic RCC. This study aimed to compare survival outcomes various therapeutic modalities from a referral center cohort database. Methods: Pts recurrent RCC previous radical surgery for localized tumor, presenting ≤5 metastatic lesions, were retrospectively analyzed. The primary endpoint was progression-free (PFS). Secondary endpoints overall (OS) and PFS subsequent...
Abstract Aim Radiation-induced oral mucositis (RIOM) is the most frequent side effect in head and neck cancer (HNC) patients treated with curative radiotherapy (RT). A standardized strategy for preventing treating RIOM has not been defined. of this study was to perform a real-life survey on management among Italian RT centers. Methods 40-question administered 25 radiation oncologists working different centers across Italy. Results total 1554 HNC have participating 2021, majority (median 91%)...
Background and purposeArtificial Intelligence (AI)-based auto-contouring for treatment planning in radiotherapy needs extensive clinical validation, including the impact of editing after automatic segmentation. The aims this study were to assess performance a commercial system Clinical Target Volumes (CTVs) (prostate/seminal vesicles) selected Organs at Risk (OARs) (rectum/bladder/femoral heads+femurs), evaluating also inter-observer variability (manual vs automatic+editing) reduction...
To evaluate toxicity and clinical outcome in synchronous bone only oligometastatic (≤2 lesions) prostate cancer patients, simultaneously irradiated to prostate/prostatic bed, lymph nodes metastases.From 2/2009 6/2015, 39 patients underwent radiotherapy (RT) at "radical" doses metastases (median 2 Gy equivalent dose, EQD2>40Gy, α/β = 1,5), nodes, within the same RT course, association with androgen deprivation therapy (ADT).Biochemical relapse-free survival, freedom from distant overall...
To implement Knowledge Based (KB) automatic planning for right and left-sided whole breast treatment through a new volumetric technique (ViTAT, Virtual Tangential-fields Arc Therapy) mimicking conventional tangential fields (TF) irradiation. A total of 193 clinical plans delivering TF with wedged or field-in-field beams were selected to train two KB-models right(R) left(L) sided cancer patients using the RapidPlan (RP) tool implemented in Varian Eclipse system. Then, template ViTAT...
We report molecular subtype impact on 1325 early breast cancer (BCa) patients treated with whole hypofractionated (WBH) adjuvant forward-planned intensity modulated radiotherapy (F-IMRT) without boost.From 02/2009-05/2017 pTis-pT3, pNx-N1aM0 BCa who underwent conservation surgery were WBHF-IMRT in our institute, to a total dose of 40 Gy/15 fractions, boost. Median age: 62 (interquartile range-IQR-:51.14-70.53) years.8% situ carcinoma (ISC), 92% invasive tumors. Molecular subtypes (invasive...
The detection of prostate cancer recurrence after external beam radiotherapy relies on the measurement a sustained rise serum prostate-specific antigen (PSA). However, this biochemical relapse may take years to occur, thereby delaying delivery secondary treatment patients with recurring tumors. To address issue, we propose use patient-specific forecasts PSA dynamics predict earlier. Our are based mechanistic model response radiotherapy, which is fit data collected during standard...
To report 10-year outcomes of WPRT and HD moderately hypofractionated SIB to the prostate in UIR, HR, VHR PCa. From 11/2005 12/2015, 224 PCa patients underwent at 51.8 Gy/28 fractions 74.2 Gy (EQD2 88 Gy) prostate. Androgen deprivation therapy (ADT) was prescribed up 86.2% patients. Median follow-up 96.3 months (IQR: 71-124.7). age 75 years 71.3-78.1). At last follow up, G3 GI-GU toxicity 3.1% 8%, respectively. Ten-year biochemical relapse-free survival (bRFS) 79.8% (95% CI: 72.3-88.1%),...
Background and purposeSpinal stereotactic body radiotherapy (SBRT) involves large dose gradients high geometrical accuracy is therefore required. The aim of this work was to assess residual intra-fraction error with a tracking robotic system for non-immobilized patients. Shifts from the first alignment (i.e. mimicking unavailability tracking) were also quantified.Materials methodsForty-two patients treated spinal metastasis (128 fractions, 4220 images) analyzed. Residual quantified as...
Background: To evaluate the efficacy of 11C-choline PET/CT (CHO-PET/CT) based helical tomotherapy (HTT) as a therapeutic approach for bone metastases in recurrent prostate cancer (PCa) patients. Methods: This retrospective study includes 20 PCa patients (median age: 67; range: 51-80 years) presenting biochemical relapse after primary treatment who underwent CHO-PET/CT HTT on positive from December 2007 to June 2014. The effectiveness has been assessed with response at 3/6/12 months, free...
Aims: Low skeletal muscle mass index (SMI) has recently emerged as an independent prognostic factor in oncological patients and it is linked with poor survival higher treatment toxicity. The present study aims to determine the possible impact of low SMI on acute toxicity oropharyngeal patients. Methods: Seventy-six locally advanced squamous cell carcinoma (stage III-IVC) were treated our institution Helical TomoTherapy® (HT - Accuray, Maddison, WI, USA) between 2005 2021. All received...