A5102749080- Inflammatory Bowel Disease
- Microscopic Colitis
- Biosimilars and Bioanalytical Methods
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders
- Immunodeficiency and Autoimmune Disorders
- Advanced Radiotherapy Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Diagnosis and treatment of tuberculosis
- Helicobacter pylori-related gastroenterology studies
- Pharmaceutical studies and practices
- Liver Diseases and Immunity
- COVID-19 Clinical Research Studies
- Prostate Cancer Treatment and Research
- Tuberculosis Research and Epidemiology
- COVID-19 and healthcare impacts
- Celiac Disease Research and Management
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 and COVID-19 Research
- Fungal and yeast genetics research
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Brain Metastases and Treatment
- Prostate Cancer Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
University of Messina
2016-2025
University of Rome Tor Vergata
2025
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2019-2024
University of Naples Federico II
2024
Azienda Ospedaliero Universitaria Maggiore della Carita
2013-2023
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2013-2023
Polytechnic University of Turin
2022
European Institute of Oncology
2018-2021
University of Milan
2018-2021
GTx (United States)
2019
Bowel ultrasonography (BUS) is a noninvasive tool for evaluating bowel activity in Crohn's disease (CD) patients. Aim of our multicenter study was to assess whether BUS helps monitor intestinal improvement/resolution following different biological therapies.Adult CD patients were prospectively enrolled at 16 sites Italy. Changes parameters [i.e. wall thickening (BWT), lesion length, echo pattern, blood flow changes and transmural healing (TH: normalization all parameters)] analyzed baseline...
The use of ustekinumab and vedolizumab as second-line therapies in patients with Crohn's disease (CD) which tumour necrosis factor alpha inhibitors (TNFi) failed is still debated. aim this study was to compare, a large multicenter observational retrospective cohort, the effectiveness therapies, assessed by clinical objective outcomes including endoscopy gastrointestinal imaging.Clinical response, remission, steroid-free remission at weeks 26 52 were evaluated propensity score-weighted...
INTRODUCTION: Patients with ulcerative colitis (UC) receiving immunosuppressive drugs are at substantial risk of colectomy. We aimed to assess the postoperative complications tofacitinib exposure before colectomy in comparison biologics. METHODS: A multicenter, retrospective, observational study was conducted patients UC who underwent total for medically refractory disease, exposed or a biologic surgery. Primary outcome occurrence any complication within 30 (early) and 90 (late) days after...
Dual Targeted Therapy (DTT) has been proposed as a novel therapeutic strategy for the management of complicated patients with Inflammatory Bowel Diseases (IBD). Our aim was to investigate safety and effectiveness this approach in real-life setting.
To evaluate high-precision external beam reirradiation (re-EBRT) for local relapse of prostate cancer (PCa) after radiotherapy.
Abstract Background In a 6-year, multicenter, prospective nested case–control study, we aimed to evaluate risk factors for incident cancer in inflammatory bowel disease (IBD), when considering clinical characteristics of IBD and immunomodulator use. The secondary end point was provide characterization types. Methods All cases occurring patients from December 2011–2017 were prospectively recorded 16 Italian Group the Study Inflammatory Bowel Disease units. Each with new diagnosis matched 2...
Purpose: To evaluate feasibility, toxicities, and clinical response in Stage IV patients treated with palliative “metabolism-guided” lattice technique. Patients Methods: From June 2020 to December 2021, 30 consecutive stage 31 bulky lesions were included this study. All received irradiation consisting of a spatially fractionated high radiation dose delivered spherical deposits (vertices, Vs) within the disease. The Vs placed at edges tumor areas different metabolisms PET exam following...
Summary Background Vedolizumab registration trials were the first to include elderly patients with moderate‐to‐severe ulcerative colitis (UC) or Crohn’s disease (CD), but few real‐life data have been reported in this population. Aims We investigated effectiveness and safety of vedolizumab matched cohorts nonelderly UC CD patients. Methods The Long‐term Italian Effectiveness (LIVE) study is a retrospective‐prospective including who started from April 2016 June 2017. Elderly (≥65 years)...
A comprehensive investigation of psychological features in chronic patients is very important for tailoring effective treatments. In this study we tested anxiety, depression, health related quality life (HR-QoL), alexithymia, coping styles, and defense mechanisms, eighty-four with Crohn disease (CD) ulcerative colitis (UC). Participants reported low to moderate HRQoL apart from alexithymia. Women experienced lower QoL higher levels anxiety depressive symptoms. Coping strategies were distress...
To evaluate the safety and efficacy of lattice radiotherapy (LRT) for large, inoperable breast cancers.
Abstract Background No data on the recently introduced infliximab (IFX) biosimilar SB2 in inflammatory bowel disease (IBD) are available. Methods The Sicilian Prospective Observational Study of Patients With IBD Treated Infliximab Biosimilar is a multicenter, observational, prospective study performed among cohort Network for Inflammatory Bowel Disease. All consecutive patients starting IFX from its introduction Sicily (March 2018) to September 2019 (18 months) were enrolled. Results Two...
Background Efficacy and safety of ustekinumab for the treatment ulcerative colitis (UC) has been demonstrated in clinical trials, but few real-world data are available so far. The aim this study was to assess effectiveness a cohort refractory UC patients.Methods Data patients with moderate severe treated were retrospectively collected. Primary endpoint steroid-free remission at weeks 24 52 therapy. Secondary endpoints response, endoscopic remission, persistence 12 months safety.Results A...
Radiotherapy represents an essential part of the therapeutic algorithm for breast cancer patients after conservative surgery. The treatment left-sided tumors has been associated with a non-negligible risk developing late-onset cardiovascular disease. cardiac perception especially increased over last years due to prolongation patients' survival owing advent new drugs and ever earlier detection through screening programs. Improvements in radiation delivery techniques could reduce...
The Montreal classification has been widely used in Crohn's disease since 2005 to categorize patients by the age of onset (A), location (L), behavior (B), and upper gastrointestinal tract perianal involvement. With evolving management paradigms disease, we aimed assess performance gastroenterologists applying classification. An online survey was conducted among participants at an international educational conference on inflammatory bowel diseases. Participants classified 20 theoretical cases...
Abstract Background Patients with inflammatory bowel disease (IBD) have an increased cardiovascular risk (CVR) and (CVD) is the leading cause of mortality in IBD patients. A more in-depth screening patients has become important EMA warning for JAK-inhibitors. The current CV stratification algorithms are based on traditional factors not considering subclinical atherosclerosis. This study aimed to stratify CVR according European Society Cardiology (ESC 2021/23) Atherosclerosis (EAS), together...
Autosomal dominant and recessive forms of progressive external ophthalmoplegia (adPEO arPEO) are mitochondrial disorders characterized by the presence multiple deletions DNA in affected tissues. Four adPEO-associated missense mutations have been identified ANT1 gene. In order to investigate their functional consequences on cellular physiology, we introduced three them at equivalent positions AAC2, yeast orthologue human ANT1. We demonstrate here that expression aac2-defective haploid strains...
Abstract Background Adalimumab (ADA) and vedolizumab (VDZ) have shown efficacy in moderate to severe ulcerative colitis (UC) patients who failed infliximab (IFX). Although, a comparative evaluation of ADA VDZ this clinical setting is currently missing. Aim The aim study compare the affected by UC IFX. Methods Clinical records from 8 Italian IBD referral centers IFX were candidates receive either or retrospectively reviewed. primary end point was therapeutic failure at week 52. Secondary...
To evaluate neurocognitive performance, daily activity and quality of life (QoL), other than usual oncologic outcomes, among patients with brain metastasis ≥5 (MBM) from solid tumors treated Stereotactic Brain Irradiation (SBI) or Whole (WBI).This multicentric randomized controlled trial will involve the enrollment 100 (50 for each arm) MBM ≥ 5, age 18 years, Karnofsky Performance Status (KPS) 70, expectancy > 3 months, known primary tumor, controllable extracranial disease, baseline...
Abstract Background and Aim Postoperative recurrence (POR) following ileocolonic resection is a major concern in patients with Crohn's disease (CD). The role of ustekinumab (UST) this setting poorly known. Methods All consecutive CD baseline colonoscopy at 6–12 months from showing POR (Rutgeerts score ≥ i2) who were treated UST after the an available post‐treatment endoscopy, extracted cohort Sicilian Network for Inflammatory Bowel Diseases (SN‐IBD). primary outcome was endoscopic success,...
Abstract Aim Radiation-induced oral mucositis (RIOM) is the most frequent side effect in head and neck cancer (HNC) patients treated with curative radiotherapy (RT). A standardized strategy for preventing treating RIOM has not been defined. of this study was to perform a real-life survey on management among Italian RT centers. Methods 40-question administered 25 radiation oncologists working different centers across Italy. Results total 1554 HNC have participating 2021, majority (median 91%)...