A5063783633- Gastrointestinal motility and disorders
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Inflammatory Bowel Disease
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Digestive system and related health
- Microbial Metabolites in Food Biotechnology
- Infant Health and Development
- Child Nutrition and Feeding Issues
- Intestinal and Peritoneal Adhesions
- Celiac Disease Research and Management
- Clinical Nutrition and Gastroenterology
- Nutrition, Genetics, and Disease
- Liver Diseases and Immunity
- Congenital gastrointestinal and neural anomalies
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
University of Pisa
1999-2023
Ospedale Cisanello
2018-2021
Azienda Ospedaliera Universitaria Pisana
2015-2021
Fondazione Ricerca Molinette
2005-2009
Princess Margaret Rose Orthopaedic Hospital
1986
Bispebjerg Hospital
1986
Hvidovre Hospital
1986
Office of the Registrar General & Census Commissioner
1986
Glostrup Hospital
1986
Bowel ultrasonography (BUS) is a noninvasive tool for evaluating bowel activity in Crohn's disease (CD) patients. Aim of our multicenter study was to assess whether BUS helps monitor intestinal improvement/resolution following different biological therapies.Adult CD patients were prospectively enrolled at 16 sites Italy. Changes parameters [i.e. wall thickening (BWT), lesion length, echo pattern, blood flow changes and transmural healing (TH: normalization all parameters)] analyzed baseline...
OBJECTIVES Helicobacter pylori is causally associated with gastritis and peptic ulcer diseases. Recent data (meta-analysis) have demonstrated that triple therapy amoxicillin, clarithromycin, a proton pump inhibitor has an eradication rate of only 74–76% new therapeutic protocols may be necessary. The aim this study was to examine whether adding bovine lactoferrin (bLf) probiotics (Pbs) the standard for H. infection could improve reduce side effects. METHODS diagnosed in 206 patients: 107...
Abstract TT virus (TTV) loads associated with the peripheral blood cells of seven patients known to carry in plasma were investigated by real‐time PCR. Whereas red cells/platelets uniformly negative, six and four yielded positive mononuclear (PBMCs) polymorphonuclear leukocytes, respectively, but viral titres generally low. Fractionation PBMCs into monocyte‐ B, T4, T8 lymphocyte‐enriched subpopulations showed no pattern that might suggest preferential association TTV one or more specific...
5HTTLPR polymorphism of serotonin transporter yields short (S) and long (L) alleles. SS LS genotypes are associated with reduced expression transporter. This cross-sectional study investigated the association symptom severity irritable bowel syndrome (IBS). Patients IBS (Rome III) healthy controls were included. Genomic DNA was extracted from saliva, alleles assessed by polymerase chain reaction. evaluated means IBS-SSS questionnaire. Two hundreds four patients (159 females; mean age:...
Abstract Background Serum gamma‐glutamyltransferase ( GGT ) activity is a sensitive but non‐specific marker of non‐alcoholic fatty liver disease NAFLD ). Recently, four fractions (big‐, medium‐, small‐, free‐ were described in humans. Aim We aimed to investigate whether specific fraction pattern associated with . Methods Gamma‐glutamyltransferase determined patients n = 90), and compared those control subjects 70), chronic hepatitis C CHC , 45) age gender matched. Results Total was elevated...
Functional gastrointestinal disorders (FGDs) are multifactorial of the gut-brain interaction. This study investigated prevalence Axis I and spectrum in patients with FGD established link between FGDs psychopathological dimensions. A total 135 consecutive were enrolled. The symptoms' severity was evaluated using questionnaires, while psychiatric evaluation by clinical interviews presence/absence mental (Diagnostic Statistical Manual-4th edition, Diagnosis) or disorders. Of patients, 42...
Inflammatory bowel disease (IBD) and polyps, are common colorectal pathologies in western society risk factors for development of cancer (CRC). Genomic instability is a hallmark connected to changes chromosomal structure, often caused by double strand break formation (DSB), aneuploidy. Cellular stress, may contribute genomic instability. In biopsies peripheral blood lymphocytes patients with IBD, polyps CRC, we evaluated 1) using the γH2AX assay as marker DSB micronuclei mononuclear kept...
Abstract Among the risk factors associated to metabolic syndrome (MetS), hypertension shows highest prevalence in Italy. We investigated relationship between newly identified serum γ-glutamyltransferase (GGT) fractions, b- s- m- f-GGT, and MetS hypertensive patients. A total of ninety-five consecutive patients were enrolled. GGT fractions analysed by gel-filtration chromatography, hepatic steatosis was evaluated ultrasound. diagnosed 36% Considering whole group, f-GGT showed positive...
Aliment Pharmacol Ther 2011; 33: 1019–1027 Summary Background Barrett’s oesophagus is regarded as the most important risk factor for development of oesophageal adenocarcinoma. According to current guidelines, treatment should be limited symptomatic oesophagus. Aim To evaluate expression Ki67, cyclooxygenase-2 (COX-2) and apoptosis in after 12 months double-dose proton pump inhibitor therapy. The effectiveness esomeprazole pantoprazole was also compared. Methods Seventy-seven nondysplastic...
Eosinophilic esophagitis is a chronic disease whose incidence and prevalence are increasing, based on genetic-driven interaction between environment immune system. Several gene loci involved in the development of have been identified. A two-step mechanism has hypothesized: TSLP-induced allergic sensitization followed by upregulation CAPNA14-related esophageal-specific pathways. Environment seems to larger effect than genetic variants. Factors that could play role allergens, drugs, colonizing...
Recent introduction of direct antiviral agents (DAAs) has completely changed the scenario regarding hepatitis C virus (HCV) treatment. Certain countries' economic health programs prioritize DAAs according to specific clinical features HCV-infected patients. The aim this study was define epidemiological, demographic and characteristics patients in Tuscany region central Italy.We enrolled HCV with chronic viral who were referred outpatient services 16 hospitals from 1 January 2015 31 December...
AIMTo build a regional database of chronic patients to define the clinical epidemiology hepatitis B virus (HBV)infected in Tuscan public health care system.