A5022531221- Inflammatory Bowel Disease
- Microscopic Colitis
- Protein Structure and Dynamics
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Genetic Neurodegenerative Diseases
- Chemical Reactions and Isotopes
- vaccines and immunoinformatics approaches
- Systemic Lupus Erythematosus Research
- Alcoholism and Thiamine Deficiency
- Pharmaceutical studies and practices
- Liver Diseases and Immunity
- Pregnancy and Medication Impact
- Heart Failure Treatment and Management
- Amazonian Archaeology and Ethnohistory
- Pituitary Gland Disorders and Treatments
- Colorectal and Anal Carcinomas
- Healthcare during COVID-19 Pandemic
- Head and Neck Surgical Oncology
- Occupational exposure and asthma
- Occupational and environmental lung diseases
- Celiac Disease Research and Management
European Bioinformatics Institute
2024-2025
University of Padua
2024
Technical University of Munich
2023
University of Messina
2022
Morpho (United States)
2022
Universidade Estadual de Campinas (UNICAMP)
2020
University of Pisa
2013-2017
Azienda Ospedaliera Universitaria Pisana
2016
Intramolecular isopeptide bonds contribute to the structural stability of proteins, and have primarily been identified in domains bacterial fibrillar adhesins pili. At present, there is no systematic method available detect them newly determined molecular structures. This can result mis-annotations incorrect modeling. Here, we present Isopeptor, a computational tool designed predict presence intramolecular experimentally Isopeptor utilizes structure-guided template matching via Jess...
Objective To evaluate the potential determinants of forced expiratory volume in 1 s (FEV1) decline workers with occupational asthma (OA) still exposed to causative agent. We hypothesised that sputum eosinophilia might be a predictor poor outcome after diagnosis. Setting, design and participants In specialistic clinical centre University Hospital Pisa, we studied 39 (28 M, 11 F) diagnosed as having OA, routinely followed up between 1990 2009. They were subgroup 94 affected by OA period: 9 had...
High confidence structure prediction models have become available for nearly all protein sequences. More than 200 million AlphaFold2 are now publicly available. We observe that there can be significant variability in the as judged by plDDT scores across a family. explored whether predictions with lower family improved use of higher templates from template structures AlphaFold2.
Background-AimsThe SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn's disease (CD) to assess epidemiological and characteristics their correlation disease-related worries, treatment satisfaction adherence, workability.MethodsThe following tools were used over 12 months assess:•disease-related worries: Rating Form Inflammatory Bowel Disease Patient Concerns,•impact workability: Work Productivity Activity Impairment-CD,•satisfaction: Treatment...
Abstract Background Vaccines development in this millennium started by the milestone work on Neisseria meningitidis B , reporting invention of Reverse Vaccinology (RV), which allows to identify vaccine candidates (VCs) screening bacterial pathogens genome or proteome through computational analyses. When NERVE (New Enhanced RV Environment), first software integrating tools perform selection VCs, was released, it prompted further field. However, problem-solving potential most, if not all,...
Motivation: Intramolecular isopeptide bonds contribute to the structural stability of proteins, and have primarily been identified in domains bacterial fibrillar adhesins pili. At present, there is no systematic method available detect them newly determined molecular structures. This can result mis-annotations incorrect modelling. Results: Here, we present Isopeptor, a computational tool designed predict presence intramolecular experimentally Isopeptor utilizes structure-guided template...
Intramembrane proteases, such as γ secretase, typically recruit multiple substrates from an excess of single-span membrane proteins. It is currently unclear to which extent substrate recognition depends on specific interactions their transmembrane domains (TMDs) with TMDs a protease. Here, we investigated large number potential pairwise between secretase and diverse set its using two different configurations BLaTM, genetic reporter system. Our results reveal significant TMD2 presenilin, the...
Vedolizumab (VDZ) is currently a good therapeutic option for ulcerative colitis (UC) and Crohn’s disease (CD); nevertheless, according to real-life studies, despite effectiveness in terms of clinical response, only 40% patients achieve Clinical Remission (CR), even less Mucosal Healing (MH). There little knowledge about early markers especially MH. A prospective observational study was carried out among with moderate-to severe UC CD who started VDZ between June 2016 2017. Primary non...
Background:The long-term outcome of Crohn's disease (CD) is still suboptimal, as stricturing and perforating are frequent many patients require multiple courses corticosteroids or surgery.Improving the has been suggested a novel treatment goal in CD, but evidence-based recommendations on how to accomplish this limited.We assessed effect early exposure immunomodulators (IMM) large population-based cohort.Methods: All 1162 CD from Inflammatory Bowel Disease South Limburg (IBDSL) registry,...
The human circadian system modulates cell activities along the 24-h time scale to assure predictive adaptation of individuals day/night alternations; it operates through interlaced molecular loops involving recurrent expression clock genes within each cell, and a central synchronization in suprachiasmatic nuclei hypothalamus. In cultures, exposure serum treatment allows obtain vitro models synchronized cells investigate periodicity morphology activities. Osteoblasts play key role regulating...
From January 1998 to 2008, the senior authors (GBL, GF) operated on 447 pituitary adenomas by transsphenoidal route with a purely endoscopic technique. Giant tumors (>3.5 cm 1 axis) were present in 166 of these patients. We report long-term results (minimum follow-up 36 months) 146 them. Ninety percent patients presented visual or field defect, and all them had signs hypopituitarism variable degree hormonal hypersecretion. One patient right-sided hemiparesis due compression internal...