A5058374861- Pharmacovigilance and Adverse Drug Reactions
- Biosimilars and Bioanalytical Methods
- SARS-CoV-2 and COVID-19 Research
- Gastroesophageal reflux and treatments
- COVID-19 Clinical Research Studies
- Inflammatory Bowel Disease
- Adenosine and Purinergic Signaling
- Inflammatory mediators and NSAID effects
- Helicobacter pylori-related gastroenterology studies
- Pharmaceutical Economics and Policy
- Pharmaceutical studies and practices
- Drug-Induced Adverse Reactions
- Computational Drug Discovery Methods
- Rheumatoid Arthritis Research and Therapies
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Polyomavirus and related diseases
- Microscopic Colitis
- Blood donation and transfusion practices
- Olfactory and Sensory Function Studies
- Gastrointestinal motility and disorders
- Academic integrity and plagiarism
- Vagus Nerve Stimulation Research
- Monoclonal and Polyclonal Antibodies Research
- Long-Term Effects of COVID-19
University of Verona
2024-2025
University of Pisa
2015-2024
Azienda Ospedaliera Universitaria Pisana
2015-2024
Agenzia Regionale di Sanità della Toscana
2008-2018
McGill University
2015-2016
Jewish General Hospital
2015-2016
University of Parma
2013
Tescan (Czechia)
2010-2012
Chemotherapy Foundation
2010
University of Florence
2010
<b>Objective</b> To determine whether pioglitazone compared with other antidiabetic drugs is associated an increased risk of bladder cancer in people type 2 diabetes. <b>Design</b> Population based cohort study. <b>Setting</b> General practices contributing data to the United Kingdom Clinical Practice Research Datalink. <b>Participants</b> A 145 806 patients newly treated between 1 January 2000 and 31 July 2013, follow-up until 2014. <b>Main outcome measures</b> The...
Monoclonal antibody (mAb) therapy has been previously exploited for viral infections, such as respiratory syncytial virus pneumonia and Ebolavirus disease. In the ongoing COVID-19 pandemic, early signals of efficacy from convalescent plasma have encouraged research development anti-SARS-CoV-2 mAbs. While many candidates are in preclinical development, we focus here on neutralizing mAbs (or mAb cocktails) that represent late-stage clinical pipeline, i.e., those currently Phase 2 or 3 trials....
In pharmacovigilance, disproportionality analyses based on individual case safety reports are widely used to detect signals. Unfortunately, publishing lacks specific guidelines, often leading incomplete and ambiguous reporting, carries the risk of incorrect conclusions when data not placed in correct context. The REporting A Disproportionality analysis for drUg Safety signal detection using PharmacoVigilance (READUS-PV) statement was developed address this issue by promoting transparent...
Disproportionality analyses using reports of suspected adverse drug reactions are the most commonly used quantitative methods for detecting safety signals in pharmacovigilance. However, their and results generally poorly reported published articles existing guidelines do not capture specific features disproportionality analyses. We here describe development a guideline (REporting A analysis drUg Safety signal detection individual case PharmacoVigilance [READUS-PV]) reporting abstracts....
Spontaneous reporting systems remain pivotal for post-marketing surveillance and disproportionality analysis (DA) represents a recognized approach early signal detection. Although DAs cannot be used per se as standalone to assess drug-related risk replace clinical judgment in the individual patient, their role irreplaceable rapid detection of rare unpredictable adverse drug reactions with strong drug-attributable component (e.g., designated medical events), especially when developed by...
The coronavirus disease 2019 (COVID-19) pandemic that hit the world in 2020 triggered a massive dissemination of information (an "infodemic") about was channeled through print, broadcast, web, and social media. This infodemic also included sensational distorted drugs likely first influenced opinion leaders people particularly active on media then other people, thus affecting choices by individual patients everywhere. In particular, has spread some approved for indications (chloroquine,...
To date, no population-based studies have specifically explored the external validity of pivotal randomized clinical trials (RCTs) biologics simultaneously for a broad spectrum immuno-mediated inflammatory diseases (IMIDs). The aims this study were, firstly, to compare patients' characteristics and median treatment duration approved IMIDs between RCTs' real-world setting (RW); secondly, assess extent biologic users treated in that would not been eligible inclusion into RCT each indication...
Abstract Sars-CoV-2 complications include pneumonia and acute respiratory distress syndrome (ARDS), which require intensive care unit admission. These conditions have rapidly overwhelmed healthcare systems, with detrimental effects on the quality of increased mortality. Social isolation strategies been implemented worldwide aim reducing hospital pressure. Among therapeutic strategies, use immunomodulating drugs, to improve prognosis, seems promising. Particularly, since ARDS are associated a...
Recent evidence indicates an involvement of P2X7 purinergic receptor (P2X7R) in the fine tuning immune functions, as well driving enteric neuron apoptosis under intestinal inflammation. However, participation this regulation neuromuscular functions remains undetermined. This study was aimed at investigating role P2X7Rs control colonic motility experimental colitis.Colitis induced rats by 2,4-dinitrobenzenesulfonic acid. P2X7R distribution examined immunofluorescence analysis. The effects...