A5037927439- Pharmaceutical Practices and Patient Outcomes
- Biosimilars and Bioanalytical Methods
- Health Systems, Economic Evaluations, Quality of Life
- Intraperitoneal and Appendiceal Malignancies
- Ovarian cancer diagnosis and treatment
- Poisoning and overdose treatments
- Cardiac electrophysiology and arrhythmias
- Medication Adherence and Compliance
- Autism Spectrum Disorder Research
- Endometrial and Cervical Cancer Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Obsessive-Compulsive Spectrum Disorders
- Inflammatory Bowel Disease
- Atrial Fibrillation Management and Outcomes
- Advanced Proteomics Techniques and Applications
- Potassium and Related Disorders
- Cannabis and Cannabinoid Research
- Artificial Intelligence in Healthcare and Education
- Urinary and Genital Oncology Studies
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Eating Disorders and Behaviors
- Endoplasmic Reticulum Stress and Disease
University of Verona
2023-2025
University of Padua
2023-2024
AULSS 2 Marca Trevigiana
2024
To date, no population-based studies have specifically explored the external validity of pivotal randomized clinical trials (RCTs) biologics simultaneously for a broad spectrum immuno-mediated inflammatory diseases (IMIDs). The aims this study were, firstly, to compare patients' characteristics and median treatment duration approved IMIDs between RCTs' real-world setting (RW); secondly, assess extent biologic users treated in that would not been eligible inclusion into RCT each indication...
Abstract Recent medical advancements have increased life expectancy, leading to a surge in patients affected by multiple chronic diseases and consequent polypharmacy, especially among older adults. This scenario increases the risk of drug interactions adverse reactions, highlighting need for medication review deprescribing reduce inappropriate medications optimize therapeutic regimens, with ultimate goal improving patients’ health quality life. position statement from Italian Scientific...
Purpose: This research aimed to develop and validate a META-algorithm combining individual immune-mediated inflammatory disease (IMID)-specific algorithms identify the exact IMID indications for incident biological drug users from claims data within context of Italian VALORE project. Methods Patients: All subjects with at least one dispensing TNF-alpha inhibitors, anti-interleukin agents, selective immunosuppressants approved IMIDs were identified databases Latium region in Italy...
In recent years, there has been an exponential increase in the generation and accessibility of electronic healthcare data, often referred to as “real-world data”. The landscape data sources significantly expanded encompass traditional databases newer such social media, wearables, mobile devices. Advances information technology, along with growth computational power evolution analytical methods relying on bioinformatic tools and/or artificial intelligence techniques, have enhanced potential...
Background Switch patterns among different biologics and from originators to biosimilars (and vice versa) can be complex in patients with psoriasis (PsO) psoriatic arthritis (PsA).
Abstract Background Bradycardia, renal failure, atrioventricular (AV) node blocking, shock, and hyperkalemia syndrome is a potentially life-threatening clinical condition characterized by bradycardia, hyperkalemia. It constitutes vicious circle in which the accumulation of pharmacologically active compounds lead to hemodynamic instability heart failure. Case presentation A 66-year-old Caucasian female patient was admitted emergency department presenting with fatigue bradycardia. Upon...
Importance Proton pump inhibitors (PPIs) are a widely prescribed class of drugs, potentially interacting with large number medicines, especially among older patients multimorbidity and polypharmacy. Beyond summary product characteristics (SPCs), interaction checkers (ICs) routinely used tools to help clinicians in medication review interventions. Objective To assess the consistency information on drugs PPIs as reported their SPCs different ICs. Design, Setting, Participants This...
Background Direct oral anticoagulants (DOACs) may be involved in drug-drug interactions (DDIs) potentially increasing the risk of adverse drug reactions. This study aimed to evaluate level agreement among interaction checkers (ICs) and DOACs' summary product characteristics (SPCs), listing DDIs attributing DDIs' severity.
Background: Diabetes, particularly type 2 diabetes (T2D), is linked with an increased risk of developing coronary heart disease (CHD). The present study aimed to evaluate potential circulating biomarkers CHD by adopting a targeted proteomic approach based on proximity extension assays (PEA). Methods: was 30 patients both T2D and (group DC), without DN) 29 but diagnosis NC). Plasma samples were analyzed using PEA, Olink Target 96 cardiometabolic panel expressed as normalized protein...
Bupropion, a multifaceted antidepressant, is associated with serious cardiotoxicity when misused. Recently, there has been noticeable increase in cases of intentional poisoning and current therapeutic interventions for bupropion overdose remain insufficient. The cardiotoxic effects the drug are primarily linked to its influence on cardiac gap junctions. Small-molecule drugs enhancing junction conductance, such as rotigaptide danegaptide, present potential antidotal agents. Testing these...
ObjectiveTo analyze the role of PCI variation (Δ-PCI) before and after neoadjuvant chemotherapy (NACT) in interval cytoreductive surgery (ICS) setting with aim to propose a scoring model for predicting both complete cytoreduction histopathologic response.MethodsA total 50 consecutive patients who underwent ICS at our institution were prospectively collected between January-2020 December-2023. was assessed exploratory ICS. The clinical histopathological response NACT determined by Δ-PCI CRS....
This case report examines the combined use of fibrinogen concentrate, four-factor prothrombin complex concentrate (PCC), and idarucizumab, a specific antidote for dabigatran, to reverse anticoagulant effects dabigatran apixaban-induced coagulopathy. An 86-year-old patient, receiving apixaban therapy, presented Emergency Department after intentionally ingesting 50 tablets dabigatran. The combination therapy contributed rapid normalization coagulation parameters stabilization patient's...
We aimed to compare the clinical utility and diagnostic accuracy of ADNEX model, ROMA score, RMI I, IV, as well two serum markers (CA125 HE4) in preoperative discrimination between benign malignant adnexal masses (AMs).
To analyze the role of PCI variation (Δ-PCI) before and after neoadjuvant chemotherapy (NACT) in an interval cytoreductive surgery (ICS) setting with aim to propose a scoring model for predicting both complete cytoreduction histopathologic response.
HIGHLIGHTS-Use of RAAS-i prior to COVID-19 was found be associated with the best outcomes -Dietotherapy alone, metformin and GLP1-Ra were related fewer hospitalizations -Use sulfonylureas in-hospital corticosteroids poor prognosis The endemic phase demands cautious therapy for older diabetic patients ABBREVIATIONS ACE2= Angiotensin-Converting Enzyme 2 ACEi= ACE inhibitors AH1N1= influenza A virus subtype H1N1 ARBs= Angiotensin II Receptor Blockers BG= Blood Glucose BMI= Body Mass Index CI=...
Nerium oleander is a toxic plant containing cardiac glycosides throughout all its parts, thereby posing severe health risks upon ingestion. The clinical manifestations of poisoning closely resemble those digoxin toxicity, encompassing spectrum gastrointestinal symptoms, neuropsychiatric disorders, and disturbances. This scientific case report describes accidental intoxication resulting from the consumption an leaves infusion misidentified as bay laurel leaves.An 84-year-old patient consumed...
There is limited literature on managing chronic lead exposure from non-removable sources such as fragments. In this case report, we present the complexities and clinical considerations involved in treating an elderly patient who sustained a comminuted knee fracture due to gunshot wound, complicated by retained This highlights absence of comprehensive guidelines for when complete fragment removal impractical. It also emphasizes importance multidisciplinary approach decision-making, while...