A5007239481- Health Systems, Economic Evaluations, Quality of Life
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Biosimilars and Bioanalytical Methods
- Pregnancy and Medication Impact
- Renal Transplantation Outcomes and Treatments
- Pharmaceutical Economics and Policy
- SARS-CoV-2 and COVID-19 Research
- Chronic Disease Management Strategies
- Asthma and respiratory diseases
- Pregnancy and preeclampsia studies
- Medication Adherence and Compliance
- Neonatal Respiratory Health Research
- Organ Transplantation Techniques and Outcomes
- Pharmaceutical Practices and Patient Outcomes
- Emergency and Acute Care Studies
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Healthcare Systems and Practices
- Pharmacovigilance and Adverse Drug Reactions
- Respiratory Support and Mechanisms
- Substance Abuse Treatment and Outcomes
- Pharmaceutical studies and practices
- Inflammatory Bowel Disease
- Rheumatoid Arthritis Research and Therapies
Azienda Sanitaria Locale Roma 3
2006-2024
Servizio Sanitario Nazionale
2012-2024
ASL Roma
2007-2024
Agenzia Regionale Parchi
2010-2024
Regional Health
2015-2023
Regione Lazio
2010-2023
Regione Campania
2018-2022
Ferro (United States)
2016
University of Florida
2016
Columbus Oncology and Hematology Associates
2016
ABSTRACT Background Specialist drug treatment is critical to overdose prevention; methadone maintenance effective, but we lack evidence for other modalities. We evaluate the impact of a range treatments opiate dependence on mortality. Methods Prospective cohort study 10 454 heroin users entering 1998–2001 in Italy followed‐up 208 person‐years and 2914 out treatment. Standardized overall mortality ratios (SMR) estimate excess risk compared general population. Cox models compare hazard ratio...
Little is known about the short-term effects of ultrafine particles.We evaluated effect particulate matter with an aerodynamic diameter <or=10 microm (PM10), <or=2.5 (PM2.5), and particles on emergency hospital admissions in Rome 2001-2005. We studied residents aged >or=35 years hospitalized for acute coronary syndrome, heart failure, lower respiratory tract infections, chronic obstructive pulmonary disease (COPD). Information was available factors indicating vulnerability, such as age...
Background Myocarditis and pericarditis following the Coronavirus Disease 2019 (COVID-19) mRNA vaccines administration have been reported, but their frequency is still uncertain in younger population. This study investigated association between Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) vaccines, BNT162b2, mRNA-1273 myocarditis/pericarditis population of vaccinated persons aged 12 to 39 years Italy. Methods findings We conducted a self-controlled case series (SCCS) using national data...
To date, no population-based studies have specifically explored the external validity of pivotal randomized clinical trials (RCTs) biologics simultaneously for a broad spectrum immuno-mediated inflammatory diseases (IMIDs). The aims this study were, firstly, to compare patients' characteristics and median treatment duration approved IMIDs between RCTs' real-world setting (RW); secondly, assess extent biologic users treated in that would not been eligible inclusion into RCT each indication...
Purpose: This research aimed to develop and validate a META-algorithm combining individual immune-mediated inflammatory disease (IMID)-specific algorithms identify the exact IMID indications for incident biological drug users from claims data within context of Italian VALORE project. Methods Patients: All subjects with at least one dispensing TNF-alpha inhibitors, anti-interleukin agents, selective immunosuppressants approved IMIDs were identified databases Latium region in Italy...
Limited real-world data on biological drug use in older patients with immune-mediated inflammatory diseases (IMIDs) exist despite these drugs carrying serious risks this population. We aimed to describe the frequency and persistence of (≥ 65 years) IMID, including bowel (IBDs), psoriatic arthritis/psoriasis, rheumatoid arthritis (RA), ankylosing spondylitis, a large Italian A retrospective cohort study using VALORE distributed claims database network from 13 regions years 2010-2022 was...
Biological drugs have improved the management of immune-mediated inflammatory diseases (IMIDs) despite being associated with important safety issues such as immunogenicity, infections, and malignancies in real-world settings.The aim this study was to explore potential a large Italian multi-database distributed network for use postmarketing surveillance biological drugs, including biosimilars, patients IMID.A retrospective cohort conducted using 13 regional claims databases during 2010-2019....
In countries where the National Health Service provides universal health coverage, socioeconomic position should not influence quality of care. We examined whether plays a role in short-term mortality and waiting time for surgery after hip fracture.Retrospective cohort study.and participants From Hospital Information System database, we selected all patients, aged at least 65 years admitted to acute care hospitals Rome fracture between 1 January 2006 30 November 2007. The each individual was...
Adherence to evidence-based drug therapy after acute myocardial infarction has increased over the last decades, but is still unsatisfactory. Our objectives are set out analyse patterns of (AMI), and evaluating socio-demographic differences.A cohort 3920 AMI patients discharged from hospital in Rome (2006-2007) was selected. Drugs claimed during 12 months discharge were retrieved. Drug utilization defined as density use (boxes claimed/individual follow-up; chronic = 6+ boxes/365 days)...
Importance: Since the beginning of Coronavirus Disease-19 (COVID-19) pandemic, Severe Acute Respiratory Syndrome-CoV-2 (SARS-CoV-2) infection has been a serious challenge for immune-compromised patients with immune-mediated inflammatory diseases (IMIDs). Objective: Our aim was to investigate impact COVID-19 in terms risks infection, hospitalization and mortality cohort rheumatoid arthritis (RA), psoriasis (PSO) or bowel disease (IBD). Furthermore, we studied SARS-CoV-2 on prescribed drug...
Background Recently published studies have reported association of COVID-19 vaccine ChAdOx1-S (Vaxzevria) with Guillain Barré Syndrome (GBS). Less is known about the safety other vaccines respect to GBS outcome. This study investigated in more than 15 million persons aged ≥12 years Italy. Methods Study population was all individuals who received at least one dose vaccines, admitted emergency care/hospital for from 27 December 2020–30 September 2021 Identification cases and receipt mRNA-1273...
Background Switch patterns among different biologics and from originators to biosimilars (and vice versa) can be complex in patients with psoriasis (PsO) psoriatic arthritis (PsA).
Abstract Purpose Whether inhaled medications improve long‐term survival in Chronic Obstructive Pulmonary Disease (COPD) is an open question. The purpose of this study to assess the impact adherence drug use on 5‐year COPD. Methods A population‐based cohort three Italian regions was conducted using healthcare linked datasets (hospitalization, mortality, drugs). Individuals (45+ years) discharged after COPD exacerbation 2006–2009 were enrolled. Inhaled daily during follow‐up determined through...
The goal of post-transplant immunosuppressive drug therapy is to prevent organ rejection while minimizing toxicities. In clinical practice, a multidrug approach commonly used and involves drugs with different mechanisms action, including calcineurin inhibitors (CNI) (tacrolimus or cyclosporine), antimetabolite (antimet) (mycophenolate azathioprine), mechanistic target rapamycin (mTOR) (sirolimus everolimus), and/or steroids. Although evidence based on several randomized trials available, the...
Abstract Background Socioeconomic status could affect the demand for hospital care. The aim of present study was to assess role age, socioeconomic and comorbidity on acute admissions among elderly. Methods We retrospectively examined discharge abstracts data care residents in Rome aged 75 or more years period 1997–2000. used Hospital Information System Rome, Tax Register, Population Register socio-economic data. rate hospitalization, modified Charlson's index comorbidity, level income census...
ABSTRACT Purpose There are some methodological concerns regarding results from observational studies about the effectiveness of evidence‐based (EB) drug therapy in secondary prevention after myocardial infarction. The present study used a nested case–control approach to address these major limitations. Methods A cohort 6880 patients discharged hospital acute infarction (AMI) 2006–2007 was enrolled and followed‐up throughout 2009. Exposure defined as adherence each terms proportion days...
To evaluate the benefit/risk profile of epoetin α biosimilar with erythropoiesis-stimulating agents (ESAs) originators when administered to naïve patients from clinical practice.
Real-world data on the comparative effectiveness and safety of switching among different epoetins (including originators biosimilars) are limited. In light current debate about interchangeability, prescribers, some patient groups decision makers calling for additional post-marketing evidence clinical effects between originator biosimilar in chronic kidney disease (CKD) patients. The objective this study was to evaluate versus non-switching from originator/biosimilar epoetin alpha (ESA α) any...
Maintenance immunosuppressive therapy used in kidney transplantation typically involves calcineurin inhibitors, such as tacrolimus or cyclosporine, combination with mycophenolate mechanistic target of rapamycin (mTORi) without corticosteroids. An Italian retrospective multicentre observational study was conducted to investigate the risk-benefit profile different regimens. We identified all subjects who underwent transplant between 2009 and 2019, using healthcare claims data. Patients on...
Cases of appendicitis were identified in the pivotal randomized clinical trial on BNT162b2 mRNA vaccine and reported from coronavirus disease 2019 (COVID-19) pharmacovigilance systems. Three cohort studies two self-controlled case series (SCCS) evaluating association between vaccines discordant results. To address this uncertainty, present study examines a large population, with SCCS design, (BNT162b2 mRNA-1273) and, for first time, viral vector (ChAdOx1-S Ad26.COV2-S) COVID-19 acute appendicitis.
To ascertain if the use of hydroxychloroquine(HCQ)/cloroquine(CLQ) and other conventional DMARDs (cDMARDs) rheumatic diseases per se may be associated with COVID-19-related risk hospitalization mortality. This case-control study nested within a cohort cDMARD users was conducted in Lombardy, Veneto, Tuscany Lazio regions Reggio Emilia province. Claims databases were linked to COVID-19 surveillance registries. The outcomes estimated using multivariate conditional logistic regression analysis...
To investigate the association of 2019-2020 influenza vaccine with prognosis patients positive for SARS-CoV-2A, a large multi-database cohort study was conducted in four Italian regions (i.e., Lazio, Lombardy, Veneto, and Tuscany) Reggio Emilia province (Emilia-Romagna). More than 21 million adults were residing area (42% population). We included 115,945 COVID-19 cases diagnosed during first wave pandemic (February-May, 2020); 34.6% these had been vaccinated against influenza. Three outcomes...
Background In immunosuppression after transplantation, several multi-drug approaches are used, involving calcineurin inhibitors ( CNI: tacrolimus-TAC or cyclosporine-CsA ), antimetabolites antiMs mammalian target of rapamycin mTORis and corticosteroids. However, data on immunosuppressive therapy by organ its space–time variability lacking. Methods An Italian multicentre observational cohort study was conducted using health information systems. Patients with incident transplant during...