A5080237017- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Ion channel regulation and function
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmacological Receptor Mechanisms and Effects
- Synthesis and pharmacology of benzodiazepine derivatives
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacovigilance and Adverse Drug Reactions
- Drug Transport and Resistance Mechanisms
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Molecular Sensors and Ion Detection
- Diet and metabolism studies
- Pharmaceutical studies and practices
- Drug-Induced Adverse Reactions
- Biosimilars and Bioanalytical Methods
- Pharmaceutical Practices and Patient Outcomes
- Rheumatoid Arthritis Research and Therapies
- Pain Mechanisms and Treatments
- Synthesis of heterocyclic compounds
- Diabetes Treatment and Management
- Cholinesterase and Neurodegenerative Diseases
- Migraine and Headache Studies
- Hepatitis C virus research
Magna Graecia University
2016-2025
Azienda Ospedaliero Universitario Mater Domini
2013-2023
Azienda Ospedaliera Pugliese Ciaccio
2022
University of Pavia
1999-2020
University of Milan
1998-2020
University of Bari Aldo Moro
1994-2020
Azienda Usl Toscana Centro
2020
Institute of Neurological Sciences
2020
University of Bologna
2020
Federico II University Hospital
2020
Purpose: To evaluate the relative contribution of demographic and epilepsy-related variables, depressive symptoms, adverse effects (AEs) antiepileptic drugs (AEDs) to health-related quality life (HRQOL) in adults with pharmacoresistant epilepsy. Methods: Individuals epilepsy whose seizures failed respond at least one AED were enrolled consecutively 11 tertiary referral centers. HRQOL was assessed by Quality Life Epilepsy Inventory-31 (QOLIE-31), AEs Adverse Event Profile (AEP), symptoms Beck...
The behavioural and electrocortical (ECoG) effects of clonidine were studied after microinjection into the third cerebral ventricle, or microinfusion some specific areas rat brain rich in noradrenaline‐containing cell bodies (locus coeruleus) receiving noradrenergic terminals (dorsal hippocampus, amygdaloid complex, thalamus, frontal sensimotor cortex). ECoG continuously analysed quantified by means a Berg‐Fourier analyser as total power preselected bands frequency. Clonidine (9.4 to 75...
One hundred and ninety-two fragile X male patients were investigated for seizures EEG findings, 168 in a retrospective 24 another prospective study, to characterize the natural history of seizures, epilepsy, abnormalities males with this syndrome.Seizures documented 35 (18.2%) 192 patients; they never started before age 2 years or after 9 years. Seizures frequently complex partial type less motor generalized type. involving frontal temporal lobes commonly seen usually well controlled by...
In this paper, we describe the synthesis of a series novel substituted 4-aryl-6,7-methylenedioxyphthalazin-1(2H)-ones. The anticonvulsant activity these compounds against audiogenic seizures was evaluated in DBA/2 mice after intraperitoneal (ip) injection. Most derivatives are more active than 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (1, GYKI 52466), well-known noncompetitive AMPA receptor antagonist. As deduced by rotarod test, all exhibit toxicity lower that 1....
Summary Purpose: To evaluate the adverse effects (AEs) of antiepileptic drugs (AEDs) in adults with refractory epilepsy and their relationship number coprescribed AEDs AED load. Methods: Patients were enrolled consecutively at 11 tertiary referral centers. AEs assessed through unstructured interview Adverse Event Profile (AEP) questionnaire. loads calculated as sum prescribed daily dose (PDD)/defined (DDD) ratios for each AED. Results: Of 809 patients enrolled, 709 had localization‐related...
Evaluate the role of platelet-rich fibrin (PRF) as a natural carrier for antibiotics delivery through analysis drug release and antimicrobial activity.PRF was prepared according to L-PRF (leukocyte- fibrin) protocol. One tube used control (without drug), while an increasing amount gentamicin (0.25 mg, G1; 0.5 G2; 0.75 G3; 1 G4), linezolid (0.5 L1; L2; 1.5 L3; 2 L4), vancomycin (1.25 V1; 2.5 V2; 3.75 V3; 5 V4) added other tubes. At different times supernatant collected analyzed. Strains E....