A5038462358- Asthma and respiratory diseases
- Advanced Proteomics Techniques and Applications
- Respiratory and Cough-Related Research
- Mass Spectrometry Techniques and Applications
- Eosinophilic Esophagitis
- Allergic Rhinitis and Sensitization
- Antimicrobial Peptides and Activities
- IL-33, ST2, and ILC Pathways
- Oral microbiology and periodontitis research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Metabolomics and Mass Spectrometry Studies
- Multiple Myeloma Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Neuropeptides and Animal Physiology
- Advanced Chemical Sensor Technologies
- Sperm and Testicular Function
- Hormonal and reproductive studies
- Crystallography and molecular interactions
- Cytokine Signaling Pathways and Interactions
- Lipoproteins and Cardiovascular Health
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
Magna Graecia University
2015-2024
Department of Medical Sciences
2013
Azienda Ospedaliero Universitario Mater Domini
2012
University of Calabria
2009
Menarini Group (Italy)
1998-2007
George Mason University
2006
The Ohio State University
2006
Dana-Farber Cancer Institute
2004
Abstract Background Due to their complexity and the presence of common clinical features, differentiation between asthma chronic obstructive pulmonary disease (COPD) can be a challenging task, complicated in such cases also by asthma–COPD overlap syndrome. The distinct immune/inflammatory structural substrates COPD are responsible for significant differences responses standard pharmacologic treatments. Therefore, an accurate diagnosis is central relevance assure appropriate therapeutic...
The present manuscript describes a biomarker capturing strategy based on nanoporous silica particles. method is shown to enrich the yield of species in low-molecular weight proteome (LMWP), allowing detection small peptides low-nanomolar range. Plasma samples were exposed particles, and captured molecular profiled using MALDI-TOF. Mass spectra silica-treated human plasma showed significant enrichment MALDI-TOF protein profiles LMWP. Preliminary results indicated good level reproducibility...
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can affect post-translational processes, thus being responsible for decreased farnesylation and geranylgeranylation of intracellular small G proteins such as Ras, Rho Rac, essential cell survival proliferation. In this regard, recent in vitro vivo studies suggest a possible role both statins farnesyl transferase the treatment malignancies. Within context, aim our study was to investigate effects either simvastatin...
Abstract Background There are several effective therapies for osteoporosis but these agents might cause serious adverse events. Lycopene intake could prevent bone loss, however studies on its effects scarce. Our aim was to investigate the of lycopene osteoblast cells as well mineral density and turnover markers in postmenopausal women. Methods We investigated effect Wnt/β-catenin ERK 1/2 pathways, RUNX2, alkaline phosphatase, RANKL COL1A Saos-2. also carried out a pilot controlled clinical...
Male infertility occurs approximately in about 50% of all cases and represents a serious concern worldwide. Traditional semen analysis alone is insufficient to diagnose male infertility. Over the past two decades, advances omics technologies have led widespread application metabolomics profiling as valuable diagnostic tool for various diseases disorders. Seminal plasma rich easily accessible source metabolites surrounding spermatozoa, milieu that provides several indispensable nutrients...
Silica-based nanoporous surfaces have been developed in order to capture low molecular weight peptides from human plasma. Harvested were subjected mass spectrometric analysis by using matrix-assisted laser desorption/ionization time-of-flight spectrometry (MALDI-TOF MS) as a means of detecting and assessing the bound molecules. Peptide profiles consisting about 70 peaks range 800-10,000 m/z generated. The method could allow detection small at ng/mL concentration levels, either standard...
Abstract Induced sputum is recognized as being of increasing importance for the diagnosis and monitoring chronic inflammatory lung diseases. The main purpose this study to provide a valid approach better fractionate characterize still under‐estimated low‐molecular weight proteome induced by using mesoporous silica beads (MSBs) SPE coupled MALDI‐TOF MS. Sputum peptides were captured from both derivatized non‐derivatized MSBs then profiled Depending on chemical groups present surface, complex...