A5079770254- COVID-19 Clinical Research Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Long-Term Effects of COVID-19
- Cardiac Imaging and Diagnostics
- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Cardiac Valve Diseases and Treatments
- COVID-19 and healthcare impacts
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and Mental Health
- Inflammasome and immune disorders
- Bipolar Disorder and Treatment
- Healthcare Policy and Management
- Cardiac Structural Anomalies and Repair
- Tuberculosis Research and Epidemiology
- Traditional Chinese Medicine Analysis
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Hormonal Regulation and Hypertension
- Global Health Care Issues
- SARS-CoV-2 and COVID-19 Research
Centro Cardiologico Monzino
2022-2024
Regione Lombardia
2020-2022
University of Milano-Bicocca
2020
Fondazione IRCCS Istituto Nazionale dei Tumori
2020
Lombardia Informatica (Italy)
2019
BackgroundA potential association between the use of angiotensin-receptor blockers (ARBs) and angiotensin-converting–enzyme (ACE) inhibitors risk coronavirus disease 2019 (Covid-19) has not been well studied.MethodsWe carried out a population-based case–control study in Lombardy region Italy. A total 6272 case patients whom infection with severe acute respiratory syndrome 2 (SARS-CoV-2) was confirmed February 21 March 11, 2020, were matched to 30,759 beneficiaries Regional Health Service...
The epidemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been spreading globally, raising increasing concerns. There are several controversial hypotheses on the potentially harmful or beneficial effects of antihypertensive drugs acting renin–angiotensin–aldosterone system (RAAS) in disease 2019 (COVID-19). Furthermore, there is accumulating evidence, based observational studies, that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin...
To evaluate medication adherence and associated factors of seven the most common drug classes prescribed to community-dwelling older people.This is a retrospective cohort study on in people (65-94 years old) chronic polypharmacy recorded from 2013 2015 administrative database Lombardy region (Northern Italy). Adherence was assessed for diabetic drugs, antithrombotic agents, drugs acting renin-angiotensin system, statins, bisphosphonates, antidepressants obstructive airway diseases by...
Abstract Background Glucagon-like peptide-1 receptor agonists (GLP-1 RA) and sodium glucose cotransporter-2 inhibitors (SGLT-2i) demonstrated cardiovascular renal protection. Whether their benefits occur also during hospitalization for acute myocardial infarction (AMI) in patients with diabetes mellitus (DM) is not known. We evaluated in-hospital outcomes of hospitalized AMI according to chronic use GLP-1 RA and/or SGLT-2i. Methods Using the health administrative databases Lombardy, from...
Biological drugs have improved the management of immune-mediated inflammatory diseases (IMIDs) despite being associated with important safety issues such as immunogenicity, infections, and malignancies in real-world settings.The aim this study was to explore potential a large Italian multi-database distributed network for use postmarketing surveillance biological drugs, including biosimilars, patients IMID.A retrospective cohort conducted using 13 regional claims databases during 2010-2019....
Poor medication adherence compromises treatment efficacy and adversely affects patients' clinical outcomes. This study aims to assess (1) multiple the most common drug classes chronically prescribed older people, (2) factors associated, (3) retrospective cohort included 122,655 community-dwelling patients aged 65-94 years old, newly exposed chronic polypharmacy, recorded in Lombardy Region (northern Italy) administrative database from 2016 2018. Multiple was assessed for drugs diabetes,...
Abstract Aims Patients with acute myocardial infarction (AMI) are at increased risk of recurrent cardiovascular events. Non-stenotic aortic valve fibro-calcific remodelling (called sclerosis; AVSc), reflecting systemic damage, may serve as a new marker risk. This study aims to stratify subgroups AMI patients specific probabilities and evaluate the importance AVSc in this setting. Methods results Consecutive (n = 2530) were admitted Centro Cardiologico Monzino (2010–19) followed up for 5...
To ascertain if the use of hydroxychloroquine(HCQ)/cloroquine(CLQ) and other conventional DMARDs (cDMARDs) rheumatic diseases per se may be associated with COVID-19-related risk hospitalization mortality. This case-control study nested within a cohort cDMARD users was conducted in Lombardy, Veneto, Tuscany Lazio regions Reggio Emilia province. Claims databases were linked to COVID-19 surveillance registries. The outcomes estimated using multivariate conditional logistic regression analysis...
Hypercoagulability is often seen in COVID-19 patients and thromboembolic events appear frequent; antithrombotic treatment has been proposed therefore as part of standard for COVID-19. Under these premises, prior-to-infection may have a protective effect with respect to related events. Aim the present work was evaluate impact anticoagulant or antiplatelet on outcomes.Beneficiaries Regional Health Service Lombardy region Italy aged ≥40 years diagnosis made between February 21st July 18th, 2020...
Abstract OBJECTIVES The European System for Cardiac Operation Risk Evaluation II (EuroSCORE II) is the most common tool used to evaluate perioperative risk of mortality after cardiac surgery in Europe, and its use currently recommended by relevant guidelines. However, recently, role has been questioned: Several papers have suggested that these algorithms may no longer be adequate prediction due an overestimation adult surgical risk. Our goal was validate EuroSCORE 30-day in-hospital patients...
Background: Patients on chronic dialysis are less likely to be treated with percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). This is due the lack of evidence from randomized trials, concerns about possible PCI-related side effects, and multimorbidity. Therefore, routine use PCI treatment patients AMI remains an unresolved issue. Methods: We analyzed data hospitalized 2003 2018, by using administrative Lombardy Health Database (Italy). were grouped according...
Abstract Background Patients with acute myocardial infarction (AMI) are at increased risk of recurrent cardiovascular events. Aortic valve sclerosis (AVSc), which reflects a systemic damage, may serve as marker risk. The aim the present study is to better stratify sub-groups AMI patients specific probabilities and evaluate importance AVSc in this setting. Methods We analyzed 2120 admitted Centro Cardiologico Monzino (2010-2019) who underwent echocardiographic evaluation for assessment....
Abstract Background Glucagon-like peptide-1 receptor agonists (GLP-1 RA) and sodium glucose cotransporter-2 inhibitors (SGLT-2i) demonstrated cardiovascular renal protection in addition to their glucose-lowering effect. Whether benefits occur also patients with diabetes mellitus (DM) during hospitalisation acute myocardial infarction (AMI) has not been investigated yet. Purpose We evaluated in-hospital outcomes of hospitalised AMI according chronic use (before hospitalisation) GLP-1 RA...
Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RA) and sodium glucose cotransporter-2 inhibitors (SGLT-2i) demonstrated cardiovascular renal protection in addition to their glucose-lowering effect. Whether benefits occur also patients with diabetes mellitus (DM) during hospitalization acute myocardial infarction (AMI) has not been investigated yet. Methods: We evaluated in-hospital outcomes of hospitalized AMI according chronic use (before hospitalization) GLP-1 RA SGLT-2i...