A5011779177- Acute Myocardial Infarction Research
- Acute Kidney Injury Research
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Chronic Kidney Disease and Diabetes
- Cardiovascular and exercise physiology
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac pacing and defibrillation studies
- Hemodynamic Monitoring and Therapy
- COVID-19 and healthcare impacts
- Cardiovascular Disease and Adiposity
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Renal and Vascular Pathologies
- Coronary Interventions and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Dialysis and Renal Disease Management
- Atherosclerosis and Cardiovascular Diseases
- Diabetes Treatment and Management
Centro Cardiologico Monzino
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
1998-2024
University of Milan
2012-2023
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2013-2023
Regione Lombardia
2023
Alessandro Manzoni Hospital
2023
Mylan (Switzerland)
2007-2023
Mylan (South Africa)
2023
Lombardia Informatica (Italy)
2023
University of Foggia
2017
Abstract Aims To evaluate the impact of COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs). Methods and Results We conducted a multicentre, observational, nationwide survey collect data for acute myocardial infarction (AMI) at CCUs throughout 1 week period during outbreak, compared with equivalent in 2019. observed 48.4% reduction AMI 2019 (P < 0.001). The was significant both ST-segment elevation [STEMI; 26.5%, 95% confidence interval (CI) 21.7–32.3; P =...
AimsCirculating microRNAs (miRNAs) may represent a novel class of biomarkers; therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma levels in humans and mice.
Patients with acute myocardial infarction undergoing primary angioplasty are at high risk for contrast-medium-induced nephropathy because of hemodynamic instability, the need a volume contrast medium, and lack effective prophylaxis. We investigated antioxidant N-acetylcysteine prevention in patients angioplasty.We randomly assigned 354 consecutive to one three groups: 116 were standard dose (a 600-mg intravenous bolus before 600 mg orally twice daily 48 hours after angioplasty), 119 double...
Nephropathy induced by exposure to radiocontrast agents, a possible complication of percutaneous coronary interventions, is associated with significant in-hospital and long-term morbidity mortality. Patients preexisting renal failure are at particularly high risk. We investigated the role hemofiltration, as compared isotonic-saline hydration, in preventing contrast-agent-induced nephropathy patients failure.We studied 114 consecutive chronic (serum creatinine concentration, >2 mg per...
Background: Contrast-induced nephropathy (CIN) frequently occurs in patients with acute ST-segment elevation myocardial infarction (STEMI) who are undergoing primary percutaneous coronary intervention, and CIN is associated a more complicated clinical course increased mortality. Objective: To investigate the association between absolute weight- creatinine-adjusted contrast volume, incidence, outcome era of mechanical reperfusion STEMI. Design: Prospective, observational study. Setting: A...
Oral activated factor XI (FXIa) inhibitors may modulate coagulation to prevent thromboembolic events without substantially increasing bleeding. We explored the pharmacodynamics, safety, and efficacy of oral FXIa inhibitor asundexian for secondary prevention after acute myocardial infarction (MI).We randomized 1601 patients with recent MI 10, 20, or 50 mg placebo once daily 6 12 months in a double-blind, placebo-controlled, phase 2, dose-ranging trial. Patients were within 5 days their...
Alveolar gas diffusion (DLCO) is impaired in chronic heart failure (CHF). Diffusion depends on membrane (DM) and the amount of blood participating exchange (VC). How DM, VC, alveolar-capillary unit behave relationship to CHF severity unknown.We measured pulmonary function, including DLCO, alveolar volume (VA), 191 patients NYHA class I-III. were grouped accordingly peak exercise oxygen uptake (pVO(2)): group <12 mL/min/kg (n=24), 12-16 (n=76), 16-20 (n=64), >20 (n=27). VA lowest severe...
Objective: To evaluate the clinical and prognostic relevance of acute kidney injury (AKI) in setting ST-elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS). Design: Prospective study. Setting: Single-center study, 13-bed intensive cardiac care unit at a University Cardiological Center. Patients: Ninety-seven consecutive STEMI patients with CS admission, undergoing intra-aortic balloon pump (IABP) support primary percutaneous coronary intervention (PCI)....
We examined circulating miRNA expression profiles in plasma of patients with coronary artery disease (CAD) vs. matched controls, the aim identifying novel discriminating biomarkers Stable (SA) and Unstable (UA) angina.An exploratory analysis plasmatic profile 367 miRNAs was conducted a group SA UA control donors, using TaqMan microRNA Arrays. Screening confirmation were performed by qRT-PCR: all found dysregulated troponin-negative (n=19) (n=34) subjects (n=20), for sex, age, cardiovascular...
Regulatory T (Treg) cells play a protective role in experimental atherosclerosis. In the present study, we investigated whether levels of circulating Treg relate to degree atherosclerosis carotid and coronary arteries.We studied 2 distinct populations: (1) 113 subjects, selected from free-living population (carotid study), which measured intima-media thickness common artery, as surrogate marker initial atherosclerosis; (2) 75 controls 125 patients with artery disease (coronary study): 36...