A5020267172- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- COVID-19 and healthcare impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Heart Rate Variability and Autonomic Control
- Peripheral Artery Disease Management
- Cardiac Arrest and Resuscitation
- Cardiac Arrhythmias and Treatments
- Cardiovascular Health and Disease Prevention
- Pericarditis and Cardiac Tamponade
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and Diving-Related Complications
- Orthopaedic implants and arthroplasty
- Viral Infections and Immunology Research
Ospedale Maggiore
2022-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2021-2025
University of Milan
2003-2023
Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
2020-2022
Ospedale San Paolo
2003-2021
Azienda Ospedaliera Sant'Andrea
2021
Vita-Salute San Raffaele University
2021
CTO Andrea Alesini
2017-2020
Azienda Sanitaria Locale di Asti
2013-2018
Regulatory T (Treg) cells play a protective role in experimental atherosclerosis. In the present study, we investigated whether levels of circulating Treg relate to degree atherosclerosis carotid and coronary arteries.We studied 2 distinct populations: (1) 113 subjects, selected from free-living population (carotid study), which measured intima-media thickness common artery, as surrogate marker initial atherosclerosis; (2) 75 controls 125 patients with artery disease (coronary study): 36...
Pharmacovigilance related to heart damage is of paramount importance at this early stage massive coronavirus disease 2019 (COVID-19) campaigns identify the profile patients risk. Systemic reactogenicity, which leads systemic adverse events, often occur after second dose. A possible explanation could be molecular mimicry between SARS-CoV-2 viral proteins and cardiac structures or a nonspecific inflammatory response secondary vaccination (1).
Chronic heart failure (CHF) may impair lung gas diffusion, an effect that contributes to exercise limitation. We investigated whether diffusion improvement is a mechanism whereby physical training increases aerobic efficiency in CHF. Patients with CHF (n = 16) were trained (40 min of stationary cycling, 4 times/wk) for 8 wk; similar sedentary patients 15) used as controls. Training increased (DlCO, +25%), alveolar-capillary conductance (DM, +15%), pulmonary capillary blood volume (VC, +10%),...
AimsPulmonary hypertension, a marker of poor prognosis in heart failure, may develop or increase during exercise. We sought to examine the determinants pulmonary hypertension at rest and exercise failure patients.
In chronic heart failure (CHF) patients, the ventilation (Ve) needed to eliminate metabolically produced CO(2) during exercise (i.e. Ve/Vco(2) slope) is a strong prognosticator. slope determinants are dead space-tidal volume (Vd/Vt) ratio and arterial partial pressure (Paco(2)). We aimed at defining respective prognostic role of these two variables.One hundred twenty-eight stable CHF patients (average left ventricular ejection fraction 34+/-10%) underwent cardiopulmonary testing blood gas...
AimPatients with asymptomatic aortic stenosis (AS) and abnormal haemodynamic responses to exercise testing are at increased risk of cardiac events. This study assesses the Doppler echocardiographic determinants a positive test in cohort patients AS.
ABSTRACT Background Evidence regarding drug‐coated balloon (DCB)‐only angioplasty in de novo lesions of large vessels is still limited and mainly focused on paclitaxel‐coated balloon. We aimed to analyze the safety efficacy sirolimus‐coated (SCB)‐only compared drug‐eluting stent (DES). Methods In this retrospective, dual‐center, case‐control study, we enrolled all consecutive patients treated between January 2022 2024 with SCB‐only lesion vessel (> 2.75 mm) a propensity‐score matched...
The diagnosis of chronic total occlusion (CTO), characterized by the complete obstruction a coronary artery for at least three months, remains challenging and can be entirely asymptomatic. Since indications performing recanalization procedure CTO do not originate from randomized controlled trials, this study aimed to assess indications, management, procedural outcomes patients undergoing percutaneous revascularization (PCI) CTO, ensuring that population was as uniform possible regarding...
Heart failure (HF) is a complex syndrome characterized by myocardial dysfunction and poor prognosis. Among multiple markers of severity, an exercise ventilation inefficiency has important clinical prognostic value. The pathophysiology determining ventilatory not definitively clarified. Three different mechanisms have been identified: (i) increased dead space, (ii) early occurrence lactic acidosis, (iii) abnormal chemoreflex and/or metaboreflex activity. Besides its value, can be influenced...
Abstract Recent clinical and demographical studies on COVID-19 patients have demonstrated that men experience worse outcomes than women. However, in most cases, the data were not stratified according to gender, limiting understanding of real impact gender outcomes. This study aimed evaluate disaggregated in-hospital explore possible interactions between cardiovascular calcifications. Data was derived from sCORE-COVID-19 registry, an Italian multicentre registry enrolled who had undergone a...
Hypertension is associated with more severe disease and adverse outcomes in COVID-19 patients. Recent investigations have indicated that hypertension might be an independent predictor of patients regardless other cardiovascular noncardiovascular comorbidities. We explored the significance coronary calcifications 694 hypertensive Score-COVID registry, Italian multicenter study conducted during first pandemic wave Western world (March-April 2020). A total 1565 admitted RNA-PCR-positive...
The indications for the treatment of patients with known atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) are clear, while less is available about management new-onset AF (NOAF) during ST-segment elevation myocardial infarction (STEMI). aim this study to evaluate mortality and clinical outcome high-risk subgroup patients. We analyzed 1455 consecutive PCI STEMI. NOAF was detected in 102 subjects, 62.7% males, a mean age 74.8 ± 10.6 years. ejection fraction (EF)...
Background: It is debated whether in patients with chronic heart failure (CHF), aspirin may contrast the clinical benefits of angiotensin-converting enzyme inhibitors (ACEIs).Two major unresolved issues CHF are these agents together can affect mortality and interaction related dose aspirin.We aimed at exploring possibilities.Methods: We evaluated more than 4000 hospitalizations a principal discharge diagnosis from January 10, 1990, to December 31, 1999.The final analysis was restricted 344...
Background Chronic heart failure (CHF) may be associated with a disordered nitric oxide (NO)–mediated regulation of the pulmonary vessel tone and permeability gas transfer across alveolar-capillary membrane. Whether enhancement NO availability is beneficial regard to these functions has not been explored. Phosphodiesterase 5 inhibitors, such as sildenafil, provide tool which test this possibility. Methods In 10 patients CHF normal subjects, before at 60 minutes after sildenafil (50 mg) or...
Lone atrial fibrillation may be associated with daily life disability and exercise limitation. The extracardiac pathophysiology of these effects is poorly explored. In 35 subjects lone (mean age 67 +/- 7 yr), we investigated pulmonary function, symptom-limited cardiopulmonary performance, muscle ergoreflex (handgrip exercise) contribution to ventilation, brachial artery flow-mediated dilation (as a measure endothelial function) before after (average interval 20 5 days) restoring sinus rhythm...