A5101799099- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Optical Coherence Tomography Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Aortic aneurysm repair treatments
- Peripheral Artery Disease Management
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac pacing and defibrillation studies
- Mechanical Circulatory Support Devices
- Angiogenesis and VEGF in Cancer
- Public Health in Brazil
- Atrial Fibrillation Management and Outcomes
- Advanced MRI Techniques and Applications
- Healthcare Systems and Public Health
- Diabetes Treatment and Management
- Cardiac Arrhythmias and Treatments
- Healthcare Regulation
- Atherosclerosis and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Lipoproteins and Cardiovascular Health
Universidade Estadual de Maringá
2010-2023
Case Western Reserve University
2012-2021
Hospitais da Universidade de Coimbra
2021
University Hospitals of Cleveland
2011-2021
University School
2008-2020
University Hospitals Cleveland Medical Center
2010-2019
Fondazione Toscana Gabriele Monasterio
2019
Bayer (Germany)
2019
St George's, University of London
2018
Massachusetts General Hospital
2012-2018
The purpose of this document is to make the output International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT) Standardization and Validation available medical scientific communities, through a peer-reviewed publication, in interest improving diagnosis treatment patients with atherosclerosis, including coronary artery disease. optical coherence tomography (IVOCT) catheter-based modality that acquires images at resolution ∼10 μm, enabling visualization blood vessel...
Background —Restenosis remains an important limitation of interventional cardiology. Therefore, we aimed to determine the safety and efficacy sirolimus (a cell-cycle inhibitor)-coated BX Velocity stents. Methods Results —Thirty patients with angina pectoris were electively treated 2 different formulations sirolimus-coated stents (slow release [SR], n=15, fast [FR], n=15). All successfully delivered, discharged without clinical complications. Independent core laboratories analyzed...
Background We have previously reported a virtual absence of neointimal hyperplasia 4 months after implantation sirolimus-eluting stents. The aim the present investigation was to determine whether these results are sustained over period 1 year. Methods and Results Forty-five patients with de novo coronary disease were successfully treated single Bx VELOCITY stent in São Paulo, Brazil (n=30, 15 fast release [group I, GI] slow [GII]) Rotterdam, Netherlands (15 release, GIII). Angiographic...
To assess platelet function profiles in diabetic and nondiabetic patients on aspirin clopidogrel therapy, two patient populations were included to investigate the 1) acute effects of a 300-mg loading dose (group 1, n = 52) 2) long-term 2, 120) compared with already treatment. Patients stratified according presence type 2 diabetes. Platelet aggregation was assessed using light transmittance aggregometry (groups 1 2). activation (P-selectin expression PAC-1 binding) determined whole-blood flow...
A growing number of patients with coronary disease have refractory angina. Preclinical and early-phase clinical data suggest that intramyocardial injection autologous CD34+ cells can improve myocardial perfusion function.Evaluate the safety bioactivity injections in angina who exhausted all other treatment options.In this prospective, double-blind, randomized, phase II study (ClinicalTrials.gov identifier: NCT00300053), 167 received 1 2 doses (1×10(5) or 5×10(5) cells/kg) mobilized an equal...
After treatment with clopidogrel, patients type 2 diabetes mellitus (T2DM) have reduced platelet inhibition compared who are not diabetic. Whether can be enhanced by increasing clopidogrel maintenance dosage in T2DM is unknown. The aim of this pilot study was to assess the functional impact a high dose suboptimal clopidogrel-induced antiplatelet effects.T2DM on chronic dual therapy were screened identify responders. latter randomized 30-day standard (75 mg; n=20) or (150 daily dose. Platelet...
Intracoronary brachytherapy appears to be a promising technology prevent restenosis. Presently, limited data are available regarding the late safety of this therapeutic modality. The aim study was determine incidence (>1 month) thrombosis after PTCA and radiotherapy.From April 1997 March 1999, we successfully treated 108 patients with followed by intracoronary beta-radiation. Ninety-one have completed at least 2 months clinical follow-up. Of these patients, 6.6% (6 patients) presented sudden...
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been used for refractory cardiogenic shock; however, it is associated with increased left ventricular afterload. Outcomes the combination of a percutaneous assist device (Impella) and VA-ECMO remains largely unknown. We retrospectively reviewed patients treated shock (2014–2016). The primary outcome was all-cause mortality within 30 days implantation. Secondary outcomes included duration support, stroke, major bleeding,...
Background Our aims were to compare coronary artery bypass grafting (CABG) and stenting for the treatment of diabetic patients with multivessel disease enrolled in Arterial Revascularization Therapy Study (ARTS) trial determine costs these 2 strategies. Methods Results Patients (n=1205) randomly assigned stent implantation (n=600; diabetic, 112) or CABG (n=605; 96). Costs per patient calculated as product each patient’s use resources corresponding unit costs. Baseline characteristics similar...
The safety and efficacy of sirolimus-eluting stenting have been demonstrated, but the outcome patients treated with this novel technology beyond first year remains unknown. We sought to evaluate angiographic, intravascular ultrasound (IVUS), clinical outcomes stents 2 years after implantation.This study included 30 Bx Velocity (slow release [SR], n=15, fast [FR], n=15) in São Paulo, Brazil. Twenty-eight underwent 2-year angiographic IVUS follow-up. No deaths occurred during period. In-stent...
Metabolic activity of cytochrome P450 (CYP) 3A4 has been associated with clopidogrel response variability. Because metabolic CYP3A4 is genetically regulated, we hypothesized that genetic variations this enzyme may contribute to variability.The CYP3A4*1B, CYP3A4*3, IVS7+258A>G, IVS7+894C>T, and IVS10+12G>A polymorphisms the gene were assessed in 82 patients a steady phase therapy. Glycoprotein (platelet glycoprotein (GP) IIb/IIIa receptor activation platelet aggregation assessed. A cohort 45...
Background— We have previously reported the safety and effectiveness of sirolimus-eluting stents for treatment de novo coronary lesions. The present investigation explored potential this technology to treat in-stent restenosis. Methods Results— Twenty-five patients with restenosis were successfully treated implantation 1 or 2 Bx VELOCITY in São Paulo, Brazil. Nine received (1.4 per lesion). Angiographic volumetric intravascular ultrasound (IVUS) images obtained after procedure at 4 12...
Despite the proven superiority of sirolimus-eluting stents (SESs) compared with bare in first year after implantation, long-term outcomes patients treated these novel devices remain unknown. Our goal was to evaluate clinical, angiographic, and intravascular ultrasound (IVUS) SESs 4 years implantation.The study included 30 Bx Velocity stenting (slow release [SR; n=15] fast [FR; n=15]). Twenty-six underwent 4-year angiographic IVUS follow-up had matched assessments at all time points (index...
The safety of drug-eluting stents in ST-segment elevation myocardial infarction (STEMI) continues to be debated. Pathological studies have demonstrated an association between uncovered struts and subsequent stent thrombosis. Optical coherence tomography can detect strut coverage vivo on a micron-scale level. We therefore used optical examine patients with STEMI treated paclitaxel-eluting (PES) bare metal (BMS).In the Harmonizing Outcomes With Revascularization Stents Acute Myocardial...