A5102856105- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Vascular Procedures and Complications
- Tissue Engineering and Regenerative Medicine
- Cardiac and Coronary Surgery Techniques
- Gastrointestinal motility and disorders
- Cardiac Fibrosis and Remodeling
- Mesenchymal stem cell research
- Angiogenesis and VEGF in Cancer
- Aortic aneurysm repair treatments
- Gastrointestinal disorders and treatments
- Coronary Artery Anomalies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Venous Thromboembolism Diagnosis and Management
- Electrospun Nanofibers in Biomedical Applications
- Healthcare Systems and Practices
- Renal and Vascular Pathologies
- Cardiac Arrhythmias and Treatments
Scripps Clinic
2012-2024
Scripps Research Institute
2024
Scripps Institution of Oceanography
2016-2022
University of Virginia Medical Center
2022
Scripps Green Hospital
2003-2020
Medical University of South Carolina
2015-2019
Scripps Health
1997-2017
Huntsville Hospital
2016
Christ Hospital
2016
Emory University
1994-2016
Coronary-stent placement is a new technique in which balloon-expandable, stainless-steel, slotted tube implanted at the site of coronary stenosis. The purpose this study was to compare effects stent and standard balloon angioplasty on angiographically detected restenosis clinical outcomes.
In animal models of coronary restenosis, intracoronary radiotherapy has been shown to reduce the intimal hyperplasia that is a part restenosis. We studied safety and efficacy catheter-based gamma radiation plus stenting restenosis in patients with previous restenosis.Patients underwent stenting, as required, balloon dilation were then randomly assigned receive irradiation iridium-192 or placebo. Clinical follow-up was performed, quantitative angiographic intravascular ultrasonographic...
AimsThe aim of this study was to determine whether platelet reactivity on clopidogrel therapy, as measured by a point-of-care function assay, is associated with thrombotic events after percutaneous coronary intervention (PCI) drug-eluting stents (DESs).
Stenting of native coronary arteries with a balloon-expandable stent was attempted in 226 patients after elective angioplasty. Delivery the device successful 213 (94%) patients. Of these, 39 received aspirin and dipyridamole only (group 1) 174 aspirin, dipyridamole, warfarin for 1-3 months 2). There no abrupt closure (less than or equal to 1 day) perioperative death either group. In-hospital complications group compared 2 were as follows: subacute (1-14 days), seven (18%) versus one (0.6%)...
Background— A growing population of patients with coronary artery disease experiences angina that is not amenable to revascularization and refractory medical therapy. Preclinical studies have indicated human CD34 + stem cells induce neovascularization in ischemic myocardium, which enhances perfusion function. Methods Results— Twenty-four (19 men 5 women aged 48 84 years) Canadian Cardiovascular Society class 3 or 4 who were undergoing optimal treatment candidates for mechanical enrolled a...
A growing number of patients with coronary disease have refractory angina. Preclinical and early-phase clinical data suggest that intramyocardial injection autologous CD34+ cells can improve myocardial perfusion function.Evaluate the safety bioactivity injections in angina who exhausted all other treatment options.In this prospective, double-blind, randomized, phase II study (ClinicalTrials.gov identifier: NCT00300053), 167 received 1 2 doses (1×10(5) or 5×10(5) cells/kg) mobilized an equal...
Background — This phase 1/2 study investigated the safety of percutaneous catheter-based gene transfer naked plasmid DNA encoding for vascular endothelial growth factor 2 (phVEGF2) to left ventricular (LV) myocardium in a prospective, randomized, double-blind, placebo-controlled, dose-escalating inoperable patients with class III or IV angina. Methods and Results A steerable deflectable 8F catheter 27-gauge needle at its distal tip was advanced percutaneously endocardial surface LV 19 (age,...
We studied the acute and chronic biological reaction to balloon-expandable intracoronary stents in adult dog. Twenty stainless steel were placed, by standard angioplasty techniques, into left anterior descending, main, or circumflex coronary arteries of 20 dogs. Angiography was performed at 1, 3, 6, 12 months animals killed groups three 8, 32 weeks, for gross, light, electronmicroscopic analysis. All dogs survived, all patent, there no evidence myocardial infarction, spasm, rupture, aneurysm...
Background —Although several early trials indicate treatment of restenosis with radiation therapy is safe and effective, the long-term impact this new technology has been questioned. The objective report to document angiographic clinical outcome 3 years after restenotic stented coronary arteries catheter-based 192 Ir. Methods Results —A double-blind, randomized trial compared Ir placebo sources in patients previous angioplasty. Over a 9-month period, 55 were enrolled; 26 29 placebo. At...
Regulatory T-cells (Tregs) play a critical role in maintaining dominant peripheral tolerance. Previous characterizations of Tregs type 1 diabetes have used antibodies against CD4 and alpha-chain the interleukin-2 receptor complex (CD25). This report extends those investigations by addition more lineage-specific marker for Tregs, transcription factor forkhead box P3 (FOXP3), subjects with diabetes, their first-degree relatives, healthy control subjects. With inclusion this marker, two...
The purpose of this investigation was to evaluate the efficacy and safety implanting expandable intravascular stents in pulmonary arteries systemic veins. Twenty-seven balloon-expandable grafts were placed 13 mongrel dogs under anesthesia. A long sheath introduced over a wire catheter or dilator into artery target vein. collapsed stainless steel mesh stent balloon an angioplasty catheter. with mounted advanced through sheath. expanded diameter as inflated, remained deflated. further larger...
The balloon-expandable intracoronary stent developed by Palmaz and Schatz is undergoing clinical evaluation for use in unfavorable anatomic situations the prevention of restenosis. Because stent's mechanism action would suggest effectiveness salvaging certain percutaneous transluminal coronary angioplasty (PTCA) failures, we retrospectively examined results emergency unplanned artery stenting failed PTCA procedures, including acute occlusion.The study population consisted all US patients...
In order to define baseline descriptive criteria for the diagnosis of mitral valve prolapse with cross-sectional echocardiography, 49 patients undergoing catheterization were examined by a real-time, two-dimensional phased array echocardiographic imaging system. Angiography was used separate into two distinct groups: 15 normal function and 34 definite prolapse. Systolic leaflet annulus motion then observed in each patient similarities differences noted between groups patients. Correlative...
Fifteen patients with symptomatic iliac artery stenosis were treated intraluminal placement of balloon-expandable stents. Before treatment, 14 had intermittent claudication, and one a limb at risk for amputation. One patient diabetes mellitus, nine hypertension, all long-term smokers. Two surgical the stent; in this was part combined revascularization procedure. All other stents placed percutaneously. The transstenotic gradient after injection vasodilating drugs distal to lesion decreased...
Balloon-expandable intraluminal stents were used to treat iliac artery stenoses or occlusions that failed respond conventional balloon angioplasty. One hundred seventy-one procedures performed in 154 patients, of whom 48 had a limb at risk for amputation. Thirty-six severe and 70 moderate intermittent claudication. At the latest follow-up examination (average, 6 months; range, 1–24 months), 137 patients demonstrated clinical benefit, 113 become asymptomatic. Eleven showed no initial six...
AVID (Angiography Versus Intravascular ultrasound-Directed stent placement) is a multicenter, randomized controlled trial designed to assess the effect of intravascular ultrasound (IVUS)-directed placement on 12-month rate target lesion revascularization (TLR).After elective coronary and an optimal angiographic result (<10% stenosis), 800 patients were Angiography- or IVUS-directed therapy. Blinded IVUS was performed in Angiography group without further In group, criteria for area stenosis,...
Despite direct immediate intervention and therapy, ST-segment-elevation myocardial infarction (STEMI) victims remain at risk for infarct expansion, heart failure, reinfarction, repeat revascularization, death.
To assess safety and feasibility of autologous adipose-derived regenerative cells (ADRCs), for treatment chronic ischemic cardiomyopathy patients.Preclinical early clinical trials suggest ADRCs have excellent potential conditions.The Athena program consisted two parallel, prospective, randomized (2:1, active: placebo), double-blind assessing intramyocardial (IM) ADRC delivery [40-million, n = 28 (ATHENA) 80-million (ATHENA II) cells, 3]). Patients with an EF ≥20% but ≤45%, multivessel...
Cardiosphere-derived cells (CDCs) are cardiac progenitor that exhibit disease-modifying bioactivity in various models of cardiomyopathy and previous clinical studies acute myocardial infarction (MI), dilated cardiomyopathy, Duchenne muscular dystrophy. The aim the study was to assess safety efficacy intracoronary administration allogeneic CDCs multicentre, randomized, double-blinded, placebo-controlled, ALLogeneic heart STem Achieve Regeneration (ALLSTAR) trial.We enrolled patients 4 weeks...
Autologous CD34+ (auto-CD34+) cells represent an attractive option for the treatment of refractory angina. Three double-blinded randomized trials (n = 304) compared intramyocardial (IM) auto-CD34+ with IM placebo injections to affect total exercise time (TET), angina frequency (AF), and major adverse cardiac events (MACE). Patient-level data were pooled from Phase I, II ACT-34, ACT-34 extension, III RENEW determine efficacy safety cells. Treatment effects TET analysed using analysis...
Autologous cardiosphere-derived cells (CDCs) were the first therapeutic modality to demonstrate myocardial regeneration with a decrease in scar size and an increase viable, functional tissue. Widespread applicability of autologous CDC therapy is limited by need for patient-specific biopsy, cell processing, quality control, resulting delays inherent logistical economic constraints. Preclinical data had demonstrated equivalent efficiency allogeneic CDCs. The ALLogeneic Heart STem Cells Achieve...