A5040849966- Neuroblastoma Research and Treatments
- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Cancer Cells and Metastasis
- Cardiac and Coronary Surgery Techniques
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Parvovirus B19 Infection Studies
- Virus-based gene therapy research
- Pancreatic function and diabetes
- Neonatal and fetal brain pathology
- Cerebrospinal fluid and hydrocephalus
- Renal Transplantation Outcomes and Treatments
- Diabetes and associated disorders
- Lung Cancer Research Studies
- Cardiac Fibrosis and Remodeling
- Neurogenesis and neuroplasticity mechanisms
- Microfluidic and Bio-sensing Technologies
- Spinal Dysraphism and Malformations
- Amoebic Infections and Treatments
- Erythrocyte Function and Pathophysiology
Haukeland University Hospital
2019
Huntsville Hospital
2016
Christ Hospital
2016
Emory University
2016
Rutgers, The State University of New Jersey
2016
Neostem (United States)
2014-2015
University of Bergen
2015
Hackensack University Medical Center
2002
University of Southern California
1982-1999
Frenchay Hospital
1999
Morphologic evaluation of bone marrow for neuroblastoma cells is a routine and important component clinical staging. Specific immunostaining malignant with monoclonal antibodies should be more sensitive, however, may improve the detection metastases provide additional prognostic information.We looked tumor in from 197 patients newly diagnosed neuroblastoma, using immunoperoxidase staining (immunocytologic analysis) examination smears specimens obtained by trephine biopsy (conventional...
Despite direct immediate intervention and therapy, ST-segment-elevation myocardial infarction (STEMI) victims remain at risk for infarct expansion, heart failure, reinfarction, repeat revascularization, death.
Tumor surveillance tests are used to detect relapse and guide the clinician in making therapeutic changes. Identification of early course disease may improve long-term survival. For patients with neuroblastoma, current conventional methods include radiologic testing, bone marrow analysis, physical examination, measurement urinary catecholamine metabolites. Immunocytologic analysis blood for detection circulating tumor cells is a highly specific sensitive method, which prove useful monitoring...
LASKY, LARRY C.; BOSTROM, BRUCE; SMITH, JUDITH; MOSS, THOMAS J.; RAMSAY, NORMA K. C. Author Information
Abstract Diabetes is a major global health issue and the number of individuals with type 1 diabetes (T1D) 2 (T2D) increases annually across multiple populations. Research to develop cure must overcome immune dysfunctions shortage pancreatic islet β cells, but these challenges have proven intractable despite intensive research effort more than past decades. Stem Cell Educator (SCE) therapy—which uses only autologous blood cells that are externally exposed cord stem adhering SCE device, has...
To determine whether occult tumor contamination of autologous bone marrow or peripheral-blood progenitor cells (PBPC) influences clinical outcome after high-dose chemotherapy in patients with stage IV breast cancer.We used an immunocytochemical assay capable detecting one cell 5 x 10(5) hematopoietic to analyze and/or PBPC collections obtained from 57 consecutive women chemotherapy-sensitive metastatic cancer who received chemotherapy. The influence on time progression, overall survival, and...
• Hepatic abscess in the neonatal period is a rare but serious disorder. To our knowledge, only 24 cases have been reported literature; this study presents 13 additional cases. The most common associated factors are sepsis, vessel cannulation, and abdominal surgery. etiologic agent variable. usually multiple liver involves other organs as well. In such instances, supportive vigorous antibiotic therapy can be offered. However, solitary does occur, theoretically amenable to surgical drainage....
Objective: To apply a new immunocytochemistry (ICC) assay to peripheral blood samples for micrometastatic circulating tumor cell detection in patients with head and neck squamous cancer (HNSCC). Design:The ICC uses established monoclonal antibodies that bind tumor-associated antigens combined an enrichment system positive selection anti-human epithelial antigen (EpCAM antibody) detect cells.Subjects: Eighteen consecutive newly diagnosed as having HNSCC are described.Results: Of the 18...
Patients undergoing high-dose chemotherapy (HDC) with autologous stem cell rescue (ASCR) may have tumor cells inadvertently infused if their product is contaminated. We used an immunocytochemical (ICC) method to analyze 31 histologically negative bone marrow (BM) specimens taken from women advanced-stage breast cancer at the time of BM harvest before HDC. All patients were treated on one three consecutive HDC protocols and received or peripheral (PSC) as ASCR. Six 26 evaluable had...
The incidence and clinical relevance of tumor cells contaminating the stem cell products patients with advanced breast cancer treated high-dose chemotherapy is uncertain because prior studies used small sample sizes lacked standardization immunocytochemistry (ICC) detection method used. We evaluated blood bone marrow samples obtained from 535 women metastatic who received unmanipulated mobilized support. Of tested, 20.6% 26.3% had contamination, respectively. Blood contamination was...
Head circumference (HC) charts are important for early detection of hydrocephalus during childhood. In low-income countries where population-based HC rarely available, occurs more commonly than in developed countries, and is usually not diagnosed enough to prevent severe brain damage. This applies Ethiopia as well. The World Health Organization (WHO) has provided standard advocated global use, but recent studies cast doubts whether these equally applicable various populations. aim the study...
Purpose We review the experience with autologous peripheral blood cell transplantation (APBCT) in children neuroblastoma at University of Minnesota. Patients and Methods Aspects collection use nine patients who had advanced (eight Evans stage IV, 1 III), were median age 4 years (range 10 months-22 years), treated high-dose chemotherapy without total body irradiation APBCT between September 1987 December 1989 are reviewed. Results A 4.8 × 108 3.3–8.9) mononuclear cells per kilogram weight...
From 1983 to 1986, 21 patients with poor prognosis neuroblastoma were treated bone marrow transplantation. This regimen included induction chemotherapy, delayed surgical resection, local irradiation, and intensive chemoradiotherapy followed by infusion of allogeneic or autologous marrow. therapeutic approach resulted in a 57% long-term survival rate (follow-up: 14–48 months), which appears be approximately three times superior conventional chemotherapy comparable group children. In addition,...
Autopsy examination of seven non-institutionalised Down syndrome patients (age ten to twenty-five years) revealed normal prevalence pre-atherosclerotic lesions. Atherosclerotic plaques were observed in one these subjects fourteen years), refuting reported implications that this population is atheroma-free. However, atheromatous aortic lesions not seen an eighth subject fifty raising the possibility atheroma-free subgroup with may exist.
Tumor surveillance tests are used to determine whether malignant cells responsive or resistant therapeutic regimens. For patients with neuroblastoma, conventional methods of not sensitive enough. Because tumor shed into the circulation, immunocytologic analysis blood may function as a monitoring system. In this study, five samples were obtained from two disseminated neuroblastoma at diagnosis and during therapy. These analyzed monoclonal antibodies immunoperoxidase staining circulating...