A5024807781- Pancreatic function and diabetes
- Diabetes and associated disorders
- Intensive Care Unit Cognitive Disorders
- Diabetes Management and Research
- Thyroid Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes Treatment and Management
- Respiratory Support and Mechanisms
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Optical Imaging and Spectroscopy Techniques
- Anesthesia and Neurotoxicity Research
- Cancer-related molecular mechanisms research
- Vagus Nerve Stimulation Research
- Cardiac, Anesthesia and Surgical Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- Advanced Nanomaterials in Catalysis
- Sepsis Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hemodynamic Monitoring and Therapy
- Bone health and treatments
- Ovarian function and disorders
- Traditional Chinese Medicine Studies
Fudan University
2019-2024
People's Liberation Army 401 Hospital
2019-2024
Huadong Hospital
2019-2024
YangPu Geriatric Hospital
2019-2023
Jinan Military General Hospital
1997-2023
Jinzhou Medical University
2023
General Hospital of Jinan Military Command
2012-2018
Military Hospital
1997-2013
University of Illinois Chicago
2011
Inability to control autoimmunity is the primary barrier developing a cure for type 1 diabetes (T1D). Evidence that human cord blood-derived multipotent stem cells (CB-SCs) can autoimmune responses by altering regulatory T (Tregs) and islet β cell-specific cell clones offers promise new approach overcome underlying T1D. We developed procedure Stem Cell Educator therapy in which patient's blood circulated through closed-loop system separates lymphocytes from whole briefly co-cultures them...
Metformin, the first-line therapy for type 2 diabetes (T2D), decreases hepatic glucose production and reduces fasting plasma levels. Dorzagliatin, a dual-acting orally bioavailable glucokinase activator targeting both pancreas liver glucokinase, postprandial in patients with T2D. In this randomized, double-blind, placebo-controlled phase 3 trial, efficacy safety of dorzagliatin as an add-on to metformin were assessed T2D who had inadequate glycemic control using alone. Eligible (n = 767)...
The prevalence of type 2 diabetes (T2D) is increasing worldwide and creating a significant burden on health systems, highlighting the need for development innovative therapeutic approaches to overcome immune dysfunction, which likely key factor in insulin resistance T2D. It suggests that modulation may be useful tool treating disease. In an open-label, phase 1/phase study, patients (N = 36) with long-standing T2D were divided into three groups (Group A, oral medications, n 18; Group B,...
Abstract Diabetes is a major global health issue and the number of individuals with type 1 diabetes (T1D) 2 (T2D) increases annually across multiple populations. Research to develop cure must overcome immune dysfunctions shortage pancreatic islet β cells, but these challenges have proven intractable despite intensive research effort more than past decades. Stem Cell Educator (SCE) therapy—which uses only autologous blood cells that are externally exposed cord stem adhering SCE device, has...
Background.Sepsis is a life-threatening condition characterized by dysregulated host immune response to infection.Currently, stress hyperglycemia frequently associated with an unfavorable prognosis in cardiovascular and cerebrovascular disease.During sepsis, the progression of inflammation often leads aberrant metabolic indicators.However, association between stress-induced ratio (SHR) sepsis patients admitted intensive care unit (ICU) remains uncertain.Objectives.This study aimed explore...
Performing spinal anaesthesia in elderly patients with ligament calcification or hyperostosis is challenging for novice practitioners. This pilot study aimed to compare the effectiveness of mixed reality-assisted puncture (MRasp) that landmark-guided (LGsp) by practitioners patients.
Background A growing body of evidence suggests that immune cell infiltration in cancer is closely related to clinical outcomes. However, there still a lack research on papillary thyroid (PTC). Methods Based single-sample gene set enrichment analysis (SSGSEA) algorithm and weighted co-expression network (WGCNA) tool, the level key modules genes associated with were identified using PTC expression data from The Cancer Genome Atlas (TCGA) database. In addition, protein-protein interactions used...
To evaluate the accuracy of mixed reality (MR)-guided visualization technology for spinal puncture (MRsp).MRsp involved following three steps: 1. Lumbar spine computed tomography (CT) data were obtained to reconstruct virtual 3D images, which imported into a HoloLens (2nd gen). 2. The patented MR system quickly recognized spatial orientation and superimposed image over real in HoloLens. 3. operator performed with structural information provided by image. A posture fixation cushion was used...
There is the ongoing debate over effect of inspired oxygen fraction (FiO2) during mechanical ventilation on postoperative atelectasis. We aimed to compare effects low (30%) and moderate (60%) FiO2 The hypothesis study was that 30% could reduce atelectasis volume compared with 60% FiO2.We performed a randomized controlled trial 120 patients. Subjects were randomly assigned receive or in 1:1 ratio. primary outcome percentage total lung measured using chest CT within 30 min after extubation....
Objectives The abnormal functional connectivity (FC) pattern of default mode network (DMN) may be key markers for early identification various cognitive disorders. However, the whole-brain FC changes DMN in delayed neurocognitive recovery (DNR) are still unclear. Our study was aimed at exploring patterns all regions and potential features as biomarkers prediction DNR using machine-learning algorithms. Methods Resting-state magnetic resonance imaging (fMRI) conducted before surgery on 74...
Anticoagulation treatment after lower limb surgery is one of the key methods to avoid thrombosis, and low-molecular-weight heparin that most frequently used in clinical practice. But uncommon side effect heparin-induced thrombocytopenia (HIT), which can develop into thrombosis if not caught early or managed incorrectly.We present a case patient who underwent hip arthroplasty experienced due HIT on 9th d following application anticoagulation. We did diagnose time applied 1 unit platelets...
Resistance to thyroid hormone (RTH) is a rare autosomal hereditary disorder characterized by increased serum (TH) levels with unsuppressed or thyrotropin concentration. It remains unknown whether the coexistence of RTH papillary carcinoma (PTC) and Hashimoto thyroiditis (HT) incidental it possesses genetic pathophysiological association. In present study, case PTC HT in an 11-year-old Chinese patient was examined clinical presentation discussed. addition, possible associations between RTH,...
Background: Elderly patients with preexisting cognitive impairment are susceptible to postoperative dysfunction (POCD). In this study, we investigated whether there is local homogeneity and functional connectivity alteration in the brain before surgery for POCD as compared that non-POCD patients. Methods: Eighty elderly undergoing major thoracic or abdominal surgeries were recruited. Resting-state MRI was scanned at least 1 day surgery. Neuropsychological tests (NPTs) performed discharge,...
Delayed neurocognitive recovery (DNR) is a common subtype of postoperative disorders. An objective approach for identifying subjects at high risk DNR yet lacking. The present study aimed to predict using the machine learning method based on multiple cognitive-related brain network features. A total 74 elderly patients (≥ 60-years-old) undergoing non-cardiac surgery were subjected resting-state functional magnetic resonance imaging (rs-fMRI) before surgery. Seed-based whole-brain connectivity...
Frailty is one of the most problematic expressions population aging, but its underlying mechanism has not been fully elucidated. Circulating galectin-3 (Gal-3) involved in pathogenesis many age-related diseases. This study aims to explore influence circulating Gal-3 on regulation frailty and aging identify potential further.In this cross-sectional analysis, Fried phenotype (FP) was assessed among 149 community elderly residents Shanghai. Peripheral blood mononuclear cells (PBMCs) were...