A5058557851- Neuroscience and Neuropharmacology Research
- Plant-Microbe Interactions and Immunity
- Plant Pathogens and Resistance
- Protein Kinase Regulation and GTPase Signaling
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Autophagy in Disease and Therapy
- Kruppel-like factors research
- Nitric Oxide and Endothelin Effects
- Autoimmune Neurological Disorders and Treatments
- CRISPR and Genetic Engineering
- Plant Parasitism and Resistance
- Advanced Sensor and Energy Harvesting Materials
- Plant Pathogens and Fungal Diseases
- Plant Pathogenic Bacteria Studies
- Cancer, Hypoxia, and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Traditional Chinese Medicine Analysis
- Apelin-related biomedical research
- Pancreatic function and diabetes
- Lipid metabolism and disorders
- Cell death mechanisms and regulation
- Hydrogels: synthesis, properties, applications
Nanjing Forestry University
2022-2025
Central China Normal University
2016-2025
Huazhong Agricultural University
2017-2025
Ministry of Agriculture and Rural Affairs
2022-2025
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2025
Jilin University
2025
Ningxia Medical University
2025
University of California, San Francisco
2017-2024
North China University of Science and Technology
2024
Hebei Medical University
2017-2024
Ca 2+ /calmodulin (CaM)-dependent kinase II (CaMKII) plays a critical role in long-term potentiation (LTP), well-established model for learning and memory through the enhancement of synaptic transmission. Biochemical studies indicate that CaMKII catalyzes phosphotransferase (kinase) reaction both itself (autophosphorylation) multiple downstream target proteins. However, whether either type phosphorylation any enhancing action remains hotly contested. We have designed series experiments to...
The corpus callosum is the largest commissural system in mammalian brain, but mechanisms underlying its development are not well understood. Here we report that neuronal activity necessary for normal and maintenance of callosal projections mouse somatosensory cortex. We labeled a subpopulation layer II/III neurons via utero electroporation traced their axons contralateral cortex at different postnatal stages. Callosal displayed region- layer-specific projection patterns within first 2 weeks...
Abnormalities in dendritic spines are manifestations of several neurodevelopmental and psychiatric diseases. TAOK2 is one the genes 16p11.2 locus, copy number variations which associated with autism schizophrenia. Here, we show that kinase activity serine/threonine encoded by required for spine maturation. depletion results unstable protrusions, mislocalized shaft-synapses, loss compartmentalization NMDA receptor-mediated calcium influx. Using chemical-genetics mass spectrometry, identified...
Wood-derived hydrogels possess satisfactory longitudinal strength but lack excellent swelling resistance and dry shrinkage when achieving high anisotropy. In this study, we displayed the preparation of highly dimensional stable wood/polyacrylamide (wood/PAM-Al3+). The alkali-treated wood retains lignin as skeleton hydrogel. Second, Al ions were added to metal coordination with lignin. Finally, by employing free radical polymerization, construct a conductive electronic network using...
Significance Two hemispheres of the neocortex are connected via a large axon bundle, corpus callosum (CC). Axons from one side cortex project primarily to equivalent cortical area on contralateral side. How this homotopic projection is achieved during development remains unclear. Quantitative analysis axons' positions within CC and their pattern after crossing midline showed that position critical for projection. Further genetic perturbations semaphorin/neuropilin-1 signaling disrupted order...
ABSTRACT Microbial solar cells (MSCs) are microbial fuel (MFCs) that generate their own oxidant and/or through photosynthetic reactions. Here, we present electrochemical analyses and biofilm 16S rRNA gene profiling of biocathodes sediment/seawater-based MSCs inoculated from the biocathode a previously described MSC. Electrochemical indicate for these second-generation MSC biocathodes, catalytic activity diminishes over time if illumination is provided during growth, whereas it remains...
Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and memory. While mechanisms underlying induction of LTP ('learning') are well understood, maintenance ('memory') has remained contentious over last 20 years. Here, we find that Ca
An imbalance in redox homeostasis consistently inhibits tumor cell proliferation and further causes regression. Thus, synchronous glutaminolysis inhibition intracellular reactive oxygen (ROS) accumulation cause severe dyshomeostasis, which may potentially become a new therapeutic strategy to effectively combat cancer.
Mechanical allodynia can be evoked by punctate pressure contact with the skin (punctate mechanical allodynia) and dynamic stimulation induced gentle touching of (dynamic allodynia). Dynamic is insensitive to morphine treatment transmitted through spinal dorsal horn a specific neuronal pathway, which different from that for allodynia, leading difficulties in clinical treatment. K + -Cl − cotransporter-2 (KCC2) one major determinants inhibitory efficiency, system cord important regulation...
Epidemiological studies show an association between inflammatory bowel disease (IBD) and increased risk of thrombosis. However, how IBD influences thrombosis remains unknown. The current study shows that formation neutrophil extracellular traps (NETs) significantly in the dextran sulfate sodium (DSS)-induced mice, which turn, contributes to thrombus a NETs-dependent fashion. Furthermore, exosomes isolated from plasma mice induce arterial venous vivo. Importantly, proinflammatory...
Abstract Podocyte apoptosis exerts a crucial role in the pathogenesis of DN. Recently, long noncoding RNAs (lncRNAs) have been gradually identified to be functional variety different mechanisms associated with podocyte apoptosis. This study aimed investigate whether lncRNA Glis2 could regulate DN and uncover underlying mechanism. The rate was detected by flow cytometry. Mitochondrial membrane potential (ΔΨM) measured using JC‐1 staining. morphology MitoTracker Deep Red Then,...
<p dir="ltr"><a href="" target="_blank">T</a>he role of the intrarenal renin-angiotensin system (iRAS) in diabetic kidney disease (DKD) progression remains unclear. In this study, we generated mice with renal tubule-specific deletion angiotensinogen (<i>Agt</i><a target="_blank">; RT-<i>Agt</i><sup><em>-/-</em></sup></a>) both Akita and streptozotocin (STZ)-induced mouse model diabetes<a target="_blank">....
SUMMARY Exploring the fundamental mechanisms of organ regeneration is crucial for advancing regenerative medicine. The axolotl tail represents a unique opportunity to study primary axis including segmented muscle, vertebrae and skin. During development, muscle stem cells (MuSCs) displayed expected specificity lineage. Tail amputation, however, induced expansion MuSC potential yielding clonal contribution connective tissue cartilage, pericytes, fibroblasts. This expanded was not observed...
Oomycete pathogens deliver a number of RxLR effector proteins into host plant cells to manipulate immunity by targeting diverse proteins. Here, we reveal that Phytophthora infestans Pi18609 targets potato B-box transcription factor (BBX), StBBX27, which was identified positively regulate late blight resistance. Silencing the ortholog NbBBX27 in Nicotiana benthamiana or RNA interfering StBBX27 increases colonization P. infestans, whereas transient expression N. stable overexpression enhances...
Personalized porous scaffold materials for bone defect repair, with adjustable mechanical strength and porosity via 3D printing technology, have made significant strides in the tissue engineering. However, their ability to regulate angiogenesis processes at site remains constrained, hindering effective coupling of angiogenesis-bone regeneration. In this study, we incorporated Nb2C MXene as a photothermal agent enhancer both osteogenesis, embedded into poly (lactic-co-glycolic...
U2AF65B is one of the splicing factors that are involved in recognition 3' site and it plays an important role plant development stress response through its mRNA function. However, not clear whether regulates gene expression a splicing-independent manner. Through mutant screening map-based cloning, protein-protein interaction, transcriptomic sequencing, whole-genome bisulfite sequencing chromatin immunoprecipitation analysis, we investigated function silencing Arabidopsis thaliana. We found...
Abstract Diabetes is a major global health issue and the number of individuals with type 1 diabetes (T1D) 2 (T2D) increases annually across multiple populations. Research to develop cure must overcome immune dysfunctions shortage pancreatic islet β cells, but these challenges have proven intractable despite intensive research effort more than past decades. Stem Cell Educator (SCE) therapy—which uses only autologous blood cells that are externally exposed cord stem adhering SCE device, has...
Neuroinflammation is a feature common to neurodegenerative diseases, such as Parkinson’s disease (PD), which might be responsive therapeutic intervention. Rotenone has been widely used establish PD models by inducing mitochondrial dysfunction and inflammation. Our previous studies have reported that pyrroloquinoline quinone (PQQ), naturally occurring redox cofactor, could prevent in rotenone induced regulating functions. In the present study, we aimed investigate effect of PQQ on...
Oomycete pathogens secrete hundreds of cytoplasmic RxLR effectors to modulate host immunity by targeting diverse plant proteins. Revealing how manipulate proteins is pivotal understanding infection processes and developing new strategies control disease. Here we show that the Phytophthora infestans effector Pi22798 interacts in nucleus with a potato class II knotted-like homeobox (KNOX) transcription factor, StKNOX3. Silencing ortholog NbKNOX3 Nicotiana benthamiana reduces colonization P....