A5049202142- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Blood transfusion and management
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Diabetes and associated disorders
- Mesenchymal stem cell research
- Iron Metabolism and Disorders
- Hematopoietic Stem Cell Transplantation
- Blood groups and transfusion
- Cardiac Arrest and Resuscitation
- Renal Transplantation Outcomes and Treatments
- Blood donation and transfusion practices
- Cardiac and Coronary Surgery Techniques
- Pancreatic function and diabetes
- Erythropoietin and Anemia Treatment
- Pressure Ulcer Prevention and Management
- Platelet Disorders and Treatments
- Wound Healing and Treatments
- Hemoglobinopathies and Related Disorders
- CAR-T cell therapy research
- Blood Coagulation and Thrombosis Mechanisms
- Hemophilia Treatment and Research
- Oral and gingival health research
- Organ Transplantation Techniques and Outcomes
- Vasculitis and related conditions
Central University Hospital of Asturias
2014-2024
Gobierno del Principado de Asturias
2024
Instituto de Investigación Sanitaria del Principado de Asturias
2021
Abstract Immune thrombotic thrombocytopenic purpura (iTTP) is a microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab approved for adults with an acute episode of iTTP in conjunction plasma exchange (PEX) and immunosuppression. The objective this study was to analyze compare the safety efficacy caplacizumab vs standard care assess effect concomitant use rituximab. A retrospective from Spanish TTP Registry patients treated those who did not receive it conducted. total 155 (77...
Thrombotic microangiopathies (TMA) are disorders defined by the presence of a microangiopathic hemolytic anemia (with characteristic hallmark schistocytes in peripheral blood smear), thrombocytopenia and organ malfunction variable intensity. thrombocytopenic purpura uremic syndrome most important forms TMA and, without adequate treatment, they associated with high morbimortality. In recent years, significant advances knowledge pathophysiology have occurred. Those allowed us to move from...
Abstract Diabetes is a major global health issue and the number of individuals with type 1 diabetes (T1D) 2 (T2D) increases annually across multiple populations. Research to develop cure must overcome immune dysfunctions shortage pancreatic islet β cells, but these challenges have proven intractable despite intensive research effort more than past decades. Stem Cell Educator (SCE) therapy—which uses only autologous blood cells that are externally exposed cord stem adhering SCE device, has...
Extracorporeal photopheresis (ECP) is an established treatment strategy in steroid-refractory graft-versus-host disease (GVHD). This study's main objective was to analyze the clinical response and impact of ECP therapy steroid dose reduction. A retrospective observational series 113 patients from 7 transplantation centers analyzed. Sixty-five (58%) had acute GVHD (aGVHD), 48 (42%) chronic (cGVHD). All procedures were performed with off-line system. The median number until achievement initial...
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare disease characterized by the presence of anti-ADAMTS13 autoantibodies. Achieving accurate information on incidence and customary management important to provide appropriate diagnostic therapeutic resources. The aim this study was determine outcomes iTTP in Spain.A cross-sectional survey carried out among Spanish hospitals, focused patients ≥16 years old attended between 2015 2017, those at follow-up before that interval....
Resistance to activated protein C (APC) is a frequent cause of thrombophilia. Most patients showing APC‐resistance have G A mutation at codon 506 the factor V that converts arginine glutamine. This present in populations worldwide with frequencies ranging from 0.01 0.05. Genotyping 150 control individuals Spanish population showed 3.33% them carried mutation. Several studies measured resistance APC (following classical functional assay) and determined genotype number thrombophilic patients,...
Few cases of transfusion-transmitted hepatitis E virus (HEV) have been published in Spain. Here, we describe a well-characterized lookback investigation HEV case at the Community Centre for Blood and Tissues Asturias (Spain).A female patient with chronic myeloid leukemia underwent an allogeneic bone marrow transplant March 2019 showed alterations liver function shortly afterwards. This received blood components from 30 different donors 3 months before transplant. Frozen plasma samples these...
Summary Immune thrombotic thrombocytopenic purpura (iTTP) is an ultra‐rare disease that seldom occurs in the elderly. Few reports have studied clinical course of iTTP older patients. In this study, we analysed characteristics at presentation and response to therapy a series 44 patients with ≥60 years diagnosis from Spanish TTP Registry compared them 209 <60 same Registry. Similar symptoms laboratory results were described both groups, except for higher incidence renal dysfunction among...
Pressure injuries, or pressure ulcers, are a common problem that may lead to infections and major complications, besides being social economic burden due the costs of treatment hospitalization. While surgery is sometimes necessary, this also has complications such as recurrence wound dehiscence. Among newer methods injury treatment, advanced therapies an interesting option. This study examines healing properties bone marrow mononuclear cells (BM-MNCs) embedded in plasma-based scaffold mouse...