A5068582563- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Science and Education Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Complement system in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Esophageal Cancer Research and Treatment
- Hematological disorders and diagnostics
- Renal Diseases and Glomerulopathies
- Gut microbiota and health
- Immune responses and vaccinations
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Cancer Treatment and Pharmacology
- Blood disorders and treatments
- Long-Term Effects of COVID-19
- RNA Interference and Gene Delivery
- Acute Myeloid Leukemia Research
- COVID-19 and healthcare impacts
- Renal Transplantation Outcomes and Treatments
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Head and Neck Cancer Studies
Hospital Universitario 12 De Octubre
2019-2024
Research Institute Hospital 12 de Octubre
2019-2022
Centro de Investigación Biomédica en Red de Cáncer
2019-2022
BACKGROUND. Passive immunotherapy with convalescent plasma (CP) is a potential treatment for COVID-19. Evidence from controlled clinical trials inconclusive.
Abstract CAR-T-cell therapy against MM currently shows promising results, but usually with serious toxicities. CAR-NK cells may exert less toxicity when redirected resistant myeloma cells. CARs can be designed through the use of receptors, such as NKG2D, which recognizes a wide range ligands to provide broad target specificity. Here, we test this approach by analyzing antitumor activity activated and expanded NK (NKAE) CD45RA − T from patients that were engineered express an NKG2D-based CAR....
Abstract Immune thrombotic thrombocytopenic purpura (iTTP) is a microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab approved for adults with an acute episode of iTTP in conjunction plasma exchange (PEX) and immunosuppression. The objective this study was to analyze compare the safety efficacy caplacizumab vs standard care assess effect concomitant use rituximab. A retrospective from Spanish TTP Registry patients treated those who did not receive it conducted. total 155 (77...
Abstract The COVID-19 pandemic has represented a major cause of morbidity/mortality worldwide, overstressing health systems. Multiple myeloma (MM) patients show an increased risk for infections and they are expected to be particularly vulnerable SARS-CoV-2 infection. Here we have obtained comprehensive picture the impact in MM on local global scale using federated data research network (TriNetX) that provided access Electronic Medical Records (EMR) from Health Care Organizations (HCO) all...
Background: Chimeric antigen receptors (CARs) have been used in the past several years cancer therapy to redirect immune effector cells. Despite impressive preliminary efficacy of CAR‐T cells multiple myeloma (MM), NK cell engineering has emerged as a competitive and safer approach. NK‐92 is universal, cheap fast “off‐the‐shelf” cellular therapeutic previously clinical trials. Although modest responses with these reported MM, their oncolytic potential can be enhanced by genetic modification....
In order to demonstrate the feasibility of preparing clinical-grade SARS-CoV-2-specific T-cells from convalescent donors and ability these cells neutralize virus in vitro, we used blood collected two COVID-19 (before after vaccination) that was stimulated with specific SARS-CoV-2 peptides followed by automated T-cell isolation using CliniMacs Prodigy medical device. To determine cytotoxic activity, HEK 293T were transfected express M protein, mimicking infection. We able quickly efficiently...
Background: The gut microbiota is involved in the regulation of normal hematopoiesis and correct development immune system. Particularly butyrate, a short chain fatty acid (SCFA) derived from microbial fermentation dietary fibers, affects cell proliferation, activation, apoptosis cytokine expression. Recent studies have focused on understanding as modulator initiation progression hematological neoplasms. In addition, plays key role efficacy toxicity antitumor treatments, especially...