A5034089921- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Blood groups and transfusion
- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- COVID-19 and healthcare impacts
- Erythrocyte Function and Pathophysiology
- Bacterial Identification and Susceptibility Testing
- Hepatitis C virus research
- Blood donation and transfusion practices
- Childhood Cancer Survivors' Quality of Life
- Lymphoma Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Autoimmune Bullous Skin Diseases
- Orthopedic Infections and Treatments
- COVID-19 Clinical Research Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Fungal Infections and Studies
- Immunotherapy and Immune Responses
- Neutropenia and Cancer Infections
- Renal Transplantation Outcomes and Treatments
- Antifungal resistance and susceptibility
- Complement system in diseases
- Blood disorders and treatments
Instituto Cajal
2021-2024
Hospital Universitario Ramón y Cajal
2019-2024
Instituto Ramón y Cajal de Investigación Sanitaria
2020-2021
Abstract Autologous hematopoietic stem cell transplantation (ASCT) improves survival in multiple myeloma (MM). However, many individuals are unable to collect optimal CD34 + and progenitor (HSPC) numbers with granulocyte colony-stimulating factor (G-CSF) mobilization. Motixafortide is a novel cyclic-peptide CXCR4 inhibitor extended vivo activity. The GENESIS trial was prospective, phase 3, double-blind, placebo-controlled, multicenter study the objective of assessing superiority...
Abstract Background During the COVID‐19 outbreak, most hospitals deferred elective surgical procedures to allow space for overwhelming number of patient admissions, expecting a decrease in routine blood component requirements. However, because transfusion support needs patients are not well known, its impact on hospital supply is uncertain. The objective this study was assess effect pandemic demand. Study Design and Methods Transfusion records during peak (March 1‐April 30, 2020) were...
Abstract Multiplex quantitative real-time PCR (MRT-PCR) using blood can improve the diagnosis of intra-abdominal candidiasis (IAC). We prospectively studied 39 patients with suspected IAC in absence previous antifungal therapy. Blood cultures, MRT-PCR, and β-D-glucan (BDG) serum were performed all patients. was defined according to 2013 European Consensus criteria. For probes targeted ITS1 or ITS2 regions ribosomal DNA. Candidaemia confirmed only four (10%), criteria present 17 (43.6%). The...
Calculation of blood volume (BV) to be processed achieve the target number CD34+ cells can accomplished by using collection efficiency 2 (CE2) formula. Our aim was develop a BV web formula.We calculated CE2 from aphereses performed between January 2015 and March 2020 in allogeneic donors patients. From May 2021, we validated formula: = ((Target product)/(CD34+ pre-apheresis × CE2)) 100. Subsequently, compared outcome procedures carried out before formula implementation (pre-formula), when...
Introduction: Biological mechanisms undergoing Richter Syndrome diffuse large B-cell lymphoma type (DLBCL-RS) from a previous chronic lymphocytic leukemia (CLL) arouse great scientific interest, but the pattern of markers expressed in DLBCL-RS cases has been scarcely studied. Our aim was to immunophenotypically characterize and compare it with prior CLL population. Methods: Retrospective unicenter study patients histologically diagnosed (DLBCL not otherwise specified subtype) or concomitant...
Topic: 26. Sickle cell disease Background: Transfusion therapy is frequent in patients with Sickle-cell (SCD). Automated red blood exchange (RBCX) can be used to manage acute and chronic complications of SCD. Advantages RBCX versus simple transfusions include less iron volume overload. It consists an isovolumetric transfusion that decreases HbS a predefined level without increasing the hematocrit, which important avoid hyperviscosity, aggravate symptoms. Aims: To analyze correlation between...