A5003115026- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- T-cell and Retrovirus Studies
- Ovarian cancer diagnosis and treatment
- Neutropenia and Cancer Infections
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Sepsis Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Adolescent and Pediatric Healthcare
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Peripheral Neuropathies and Disorders
- Signaling Pathways in Disease
- DNA Repair Mechanisms
- Hemodynamic Monitoring and Therapy
- CNS Lymphoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
Hospital Universitario Puerta de Hierro Majadahonda
2024-2025
Hospital General Universitario Gregorio Marañón
2018-2024
Hospital Universitario Fundación Jiménez Díaz
2014-2019
Universidad Autónoma de Madrid
2014-2018
Imperial College London
2016-2017
Hammersmith Hospital
2016
Abnormal coagulation parameters have been reported in COVID-19-infected patients. Although the underlying mechanism of COVID-19 coagulopathy remains unknown, it has suggested to be a form disseminated intravascular (DIC).The aim our study was analyze patients with COVID-19, determine whether factors consumption occurs and identify potential prognostic biomarkers disease.Blood samples from hospitalized pneumonia were collected. We performed basic tests quantification physiological inhibitor...
Summary The diagnostic criteria for follicular lymphoma ( FL ) transformation vary among the largest series, which commonly exclude histologically‐documented HT mandatorily. aims of this retrospective observational multicentre study by Spanish Grupo Español de Linfoma y Transplante Autólogo Médula Ósea, recruited 1734 patients (800 males/934 females; median age 59 years), diagnosed with grades 1–3A, were, (i) cumulative incidence CI ‐ ); (ii) risk factors associated ; and (iii) role...
Follicular lymphoma (FL) is an indolent but largely incurable disease. Some patients suffer histological transformation to a more aggressive subtype with poorer prognosis. This study aimed improve our understanding of the genetics underlying FL transformation, and identify genetic drivers or promoters by elucidating differences between samples from who did not transform. We conducted targeted massive parallel sequencing 22 pre-transformed FL/transformed diffuse large B-cell pairs 20...
Chimeric antigen receptor T-cells (CAR-T) has emerged as a promising therapy, over 60% of patients fail to sustain long-term response. The underlying factors that leads the effectiveness this therapy are not completely understood, CAR-T cell persistence and monitoring seems be pivotal for ensuring successful Various methods such multiparametric flow cytometry (MFC) or quantitative PCR (qPCR) have been applied. Our objective is develop digital (dPCR) assays detection quantification cells,...
Abstract Background Extracorporeal photopheresis (ECP) product characteristics are not well established. The aim of this study was to compare mononuclear cells (MNCs) collection using the new Amicus blue (AB) In‐line ECP system our standard Off‐line Optia apheresis device and MacoGenic G2 inactivation (OM). Study Design Methods We assessed products procedure parameters, patient characteristics, adverse events for both AB OM systems in paired patients. Comparisons were made with t ‐test...
The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type abnormalities, would allow identification high-risk T-ALL patients. Complex karyotype defined by presence ≥3 alterations identified patients with poor prognosis this study. Karyotypes abnormalities accounted for 16 % (22/139) all evaluable karyotypes, corresponding to...
Summary The use of immunochemotherapy has improved the outcome follicular lymphoma ( FL ). Recently, complete response at 30 months CR 30) been suggested as a surrogate for progression‐free survival. This study aimed to analyse life expectancy patients according their status from start treatment in comparison with sex and age‐matched Spanish general population (relative survival; RS training series comprised 263 consecutively diagnosed 10‐year period who needed therapy were treated...
Abstract Follicular lymphoma (FL) is the second most common non‐Hodgkin (NHL) subtype. The histological transformation (HT) of FL an event considered frequent in natural history this tumor. We studied rates, predictive factors, and treatment characteristics that may impact survival patients with HT. A total 1074 diagnosed were prospectively enrolled from 1990 to 2016 a Spanish registry. Sixty‐four HTs recorded based on clinical criteria (55%) or confirmation (45%). cumulative incidence rate...
Introduction Methotrexate intoxication following high-dose methotrexate-induced acute kidney injury is a life-threatening complication. Glucarpidase can quickly reduce extracellular methotrexate to safe levels, but the effectiveness and safety of its use in different episodes nephrotoxicity remain an unknown area. Case Report A 30-year-old male diagnosed with lymphoblastic T-cell lymphoma received 5 g/m2 intravenous (IV) as part first consolidation cycle. On Consolidation 3, he restarted at...
Red blood cell (RBC) transfusion remains an essential part of sickle disease (SCD) management but it can lead to alloimmunisation, with increased incidence in this population. Prevention is based on RBC antigen phenotype matching, complete RH and Kell matching being a standard care.We performed retrospective, single-centre study analysing alloimmunisation prevalence risk factors cohort transfused SCD patients.Eighty-seven patients (96.5% paediatric age) received 1,781 units (RBCu). Complete...
The uveitis masquerade syndromes (UMS) are a group of ocular diseases that may mimic chronic intraocular inflammation. Many malignant entities such as non-Hodgkin's lymphomas uveitis. We report case an HIV-positive patient with syndrome presenting unilateral uveitis.45-year-old Caucasian man diagnosis diffuse large B-cell lymphoma (DLBCL). was diagnosed by biopsy abdominal mass which showed fragments gastric mucosa growth neoplastic cells. At diagnosis, the suffered from blurring vision and...
Abstract Background Allogeneic stem cell transplantation is the treatment of choice for acute myeloid leukemia (AML) patients. Unmanipulated haploidentical (Haplo‐HSCT) commonly used those AML patients who need a timely transplant and do not have suitable matched donor, but relapse rates are still high, improvements needed. Adoptive immunotherapy using natural killer cells (NK cells) could be promising tool to improved Haplo‐HSCT but, date, no optimal infusion manufacturing protocols been...
Chimeric antigen receptor (CAR) T-cell therapy is increasingly used in patients affected by B-cell lymphoma and acute lymphoblastic leukemia. For logistical reasons, initial apheresis products may be cryopreserved for shipment to manufacturing centers. Due the characteristics of these patients, cells are often collected large volumes, meaning more bags must cryopreserved. This requires increased storage, time monetary costs. In this context, we aimed evaluate a high cell concentration...
Background: The use of immunochemotherapy has substantially increased the outcome patients with follicular lymphoma (FL). Nowadays, life expectancy for those reaching a durable response is excellent. Recently, complete at 30 months (CR30) been suggested as surrogate progression-free survival. aim this study was to analyze FL according their status from start treatment in comparison sex and age-matched Spanish general population (relative survival; RS).
Diagnosis and treatment of hematological cancers is usually provided in many healthcare facilities including large but also middle size centers.1 Providing cancer care local institutions might be advantageous for patients caregivers terms financial burden quality life. However, it carry potential risks derived the limited experience smaller centers differences accessibility to complex therapies allogeneic hematopoietic cell transplantation (allo-HCT) chimeric antigen receptor (CAR) T-cells....