A5088989518- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Blood groups and transfusion
- Central Venous Catheters and Hemodialysis
- Prenatal Screening and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Childhood Cancer Survivors' Quality of Life
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Neonatal Health and Biochemistry
- Respiratory Support and Mechanisms
- Acute Lymphoblastic Leukemia research
- Child Abuse and Related Trauma
- Congenital Diaphragmatic Hernia Studies
- COVID-19 and healthcare impacts
- Clostridium difficile and Clostridium perfringens research
- Viral gastroenteritis research and epidemiology
- Child Abuse and Trauma
- Erythrocyte Function and Pathophysiology
- Methemoglobinemia and Tumor Lysis Syndrome
- Renal Diseases and Glomerulopathies
- Toxoplasma gondii Research Studies
- Immunodeficiency and Autoimmune Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Homicide, Infanticide, and Child Abuse
Centro de Investigación Biomédica en Red
2024
Hospital General Universitario Gregorio Marañón
2014-2024
Universidad Complutense de Madrid
2020-2024
Hospital Materno-Infantil
2020
Sickle Cell Disease (SCD) is an increasing global health problem and presents significant challenges to European care systems. Newborn screening (NBS) for SCD enables early initiation of preventive measures has contributed a reduction in childhood mortality from SCD. Policies methodologies NBS vary different countries, this might have consequences the quality clinical outcomes across Europe. A two-day Pan-European consensus conference was held Berlin April 2017 order appraise current status...
Summary Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL). We analysed data from 29 children with ALL treated under compassionate use blinatumomab, or both. The complete remission (CR) rate a heavily pretreated population overt relapse was 47·6%. At earlier stages (first/second CR), both antibodies represented useful tool reduce minimal residual disease, and/or avoid further toxic until stem cell...
Describir las características clínico-epidemiológicas, el manejo y seguimiento de sospechas maltrato infantil diagnosticadas en Urgencias Pediátricas. Estudio observacional, unicéntrico, retrospectivo realizado entre 2008 2017. Se recogieron datos clínicos, epidemiológicos los menores 16 años diagnosticados sospecha maltrato. realizó un análisis descriptivo analítico, bivariante multivariante. consideró potencial 404 pacientes 570.648 urgencias atendidas (0,07%). El físico fue más frecuente...
Abstract Introduction The increase in the number of patients with hemoglobinopathies Europe recent decades highlights need for more detailed epidemiological information Spain. To fulfil this need, Spanish Society Pediatric Hematology and Oncology (SEHOP) sponsored creation a national registry known as REHem-AR (Spanish Registry Hemoglobinopathies Rare Anemias). Data from transfusion-dependent (TDT) non–transfusion-dependent (NTDT) β-thalassemia cohorts are described analyzed. Methods We...
Background: Several evidence-based guidelines for the management of children with febrile neutropenia (FN) have been published, special focus in bacterial and fungal infections. However, role acute respiratory infections caused by viruses (RV) has not clearly established. The aim this study was to evaluate epidemiology, clinical presentation outcome FN. Methods: Patients, <18 years age admitted Pediatric Oncology-Hematology Unit after developing FN between November 2010 December 2013,...
Clostridium difficile is the leading cause of nosocomial and antibiotic-associated diarrhea in adults, its incidence has substantially risen over last few years. The prevalence this infection children difficult to assess due high rates colonization setting.A one-year retrospective study was conducted on under 15 years admitted hospital with acute diarrhea. Epidemiological, clinical, laboratory findings outcome (CDI) were compared other causes Risk factors for CDI identified by multivariate...
The aim of this study was to describe the characteristics vaso-occlusive crises (VOC) in children with sickle cell disease and identify factors associated greater severity. We performed a prospective observational from August 2012 January 2014. population comprised patients who consulted at emergency department (ED) for VOC. recorded demographic variables, history complications related disease, data on usual treatment. also assessed pain, analgesia home, need admission, length stay, during...
Introduction Cerebellar mutism syndrome (CMS) is a common complication after posterior fossa tumor resection. It characterized by significant lack or loss of speech. Its biological origin remains unclear and there are no standardized treatments. However, bromocriptine seems to be possible treatment for this condition. Case report In paper, we present three cases pediatric patients (4, 5, 17-year old) who developed CMS surgery. They were treated with improve neurological symptoms. Management...
To describe the clinical and epidemiological features, management, follow-up of child abuse suspicions diagnosed in Paediatric Emergency Unit. A single-centre, observational retrospective study was conducted between 2008 2017. Clinical, data were collected those patients younger than 16 that reported as suspicions. descriptive analytic performed, well a bivariate multivariate analysis. total 404 out 570,648 emergency (0.07%) with potential abuse. Physical most frequent kind (40.3%). The...
Red blood cell (RBC) transfusion remains an essential part of sickle disease (SCD) management but it can lead to alloimmunisation, with increased incidence in this population. Prevention is based on RBC antigen phenotype matching, complete RH and Kell matching being a standard care.We performed retrospective, single-centre study analysing alloimmunisation prevalence risk factors cohort transfused SCD patients.Eighty-seven patients (96.5% paediatric age) received 1,781 units (RBCu). Complete...
Toxoplasma gondii infection is a severe complication of hematopoietic stem-cell transplantation (HSCT) recipients that can remain unnoticed without high clinical suspicion. We present the case 6-year-old patient with acute lymphoblastic leukemia and HSCT recipient who was admitted to Pediatric Intensive Care Unit (PICU) on post-transplantation day +39 fever, hypotension, respiratory distress appearance lumbar subcutaneous node. She developed Acute Respiratory Distress Syndrome (ARDS)...
Pediatric patients with sickle cell disease and thalassemia major present clinical characteristics that could lead to a higher incidence of central venous access devices-associated complications (CVAD-C). With the objective analyzing safety use CVAD in these patients, retrospective review including all pediatric pathologies who required implantation between 2004 2019 was performed. In all, 54 100 (65 totally implantable port subcutaneous reservoir, 35 single-lumen or double-lumen partially...
Robust and applicable risk-stratifying genetic factors at diagnosis in pediatric T-cell acute lymphoblastic leukemia (T-ALL) are still lacking, most protocols rely on measurable residual disease (MRD) assessment. In our study, we aimed to analyze the impact of NOTCH1, FBXW7, PTEN , RAS mutations, levels assessed by flow cytometry (FCM-MRD) other reported risk a Spanish cohort T-ALL patients. We included 199 patients treated with SEHOP PETHEMA consecutive from 1998 2019. observed better...
Pulse oximetry in a 15-month-old boy with cyanosis revealed low oxygen saturation (SpO2 60%) normal echocardiography findings. Arterial blood gas analysis showed PaO2, hemoglobin saturation, and high methemoglobin level. Blood mild hemolytic anemia. HPLC electrophoresis variant the A2-window C/E band respectively. Beta-globin gene sequencing heterozygous M Saskatoon [Beta63 (E7) His > Tyr; HBB: c 190C T] along alpha + thalassemia. Hemoglobins are structural variants that stabilize heme iron...