Marisa Navarro
A5088205627- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- HIV-related health complications and treatments
- Long-Term Effects of COVID-19
- COVID-19 Impact on Reproduction
- Hepatitis C virus research
- Cytomegalovirus and herpesvirus research
- Pleural and Pulmonary Diseases
- COVID-19 and healthcare impacts
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- HIV, Drug Use, Sexual Risk
- Yeasts and Rust Fungi Studies
- COVID-19 and Mental Health
- IgG4-Related and Inflammatory Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Pneumocystis jirovecii pneumonia detection and treatment
- Vasculitis and related conditions
- Adolescent Sexual and Reproductive Health
- Thermal Regulation in Medicine
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
Hospital General Universitario Gregorio Marañón
2010-2025
Universidad Complutense de Madrid
2017-2024
Instituto de Salud Carlos III
2017-2024
Centro de Investigación Biomédica en Red
2022-2024
Spanish Clinical Research Network
2024
University College London
2024
Great Ormond Street Hospital
2024
Collaborative Group (United States)
2017
Centro Nacional de Medicina Tropical
2017
Research Institute Hospital 12 de Octubre
2005
Abstract The aim of this transversal study was to describe the virological and immunological features HIV-infected youths transferred from pediatric adult care units since 1997 vs. non-transferred patients Madrid Cohort children adolescents in Spain. We included 106 184 under clinical follow-up 17 public hospitals by end December 2017. Virological outcomes were compared patients. ART drug resistance mutations HIV-variants analyzed all subjects with available pol genotypes and/or genotypic...
BackgroundPost-COVID-19 condition has recently been defined as new or persistent common COVID-19 symptoms occurring three months after disease onset. The pathology of the is unclear, but immune and vascular factors seem to play a significant role. incidence, severity, implications infection in pregnancy have not established. We aimed study incidence main risk for post-COVID-19 an obstetric population their maternal perinatal morbimortality.MethodsThis prospective observational cohort...
The emergence of drug resistance in Plasmodium falciparum has been a major contributor to the global burden malaria. Drug complicates treatment, and it is one most important problems malaria control. This study assessed level mutations P. genes, pfdhfr, pfdhps, pfmdr1, pfcrt, related different anti-malarial drugs, Continental Region Equatorial Guinea, after 8 years implementing artesunate combination therapies as first-line treatment. A triple mutant pfdhfr (51I/59R/108N), which conferred...
Published estimates of mortality and progression to AIDS as children with HIV approach adulthood are limited. We describe rates risk factors for death AIDS-defining events in adolescents after initiation combination antiretroviral therapy (cART) 17 middle- high-income countries, including some Western Central Europe (W&CE), Eastern (Russia Ukraine), Thailand.Children perinatal aged <18 years initiating cART were followed until their 21st birthday, transfer adult care, death, loss follow-up,...
Objectives: To estimate the probability of long-term nonprogression (LTNP) in absence antiretroviral treatment (ART) children with perinatally acquired HIV, and impact LTNP definitions on these estimates. Design: Analysis longitudinal routine care data (follow-up to 2016) collected through a collaboration cohorts HIV across Europe Thailand. Methods: was defined as reaching age 8 years without disease progression (defined an AIDS diagnosis or immunosuppression based WHO...
El Calendario de Inmunizaciones la AEP para 2024, con sus recomendaciones inmunización embarazadas, niños y adolescentes residentes en España, hace el número 25 desde primero presentado 1995, siendo anual 2003, como calendario vacunaciones, 2023 inmunizaciones por inclusión un anticuerpo monoclonal prevención enfermedad VRS. Como novedades este año, se encuentran las siguientes: Tabla sistemáticas personas sanas otra pertenecientes a grupos riesgo. Aunque ya anteriormente hacían vacunación...
Abstract Background Strategies aimed at antiretroviral therapy (ART)–free remission will target individuals with a limited viral reservoir. We investigated factors associated low reservoir measured as total human immunodeficiency virus type 1 (HIV-1) DNA in peripheral blood mononuclear cells (PBMCs) perinatal infection (PaHIV). Methods Children from 7 European centers the Early Treated Perinatally HIV Infected Individuals: Improving Children’s Actual Life (EPIICAL) consortium who commenced...
Advances in care and antiretroviral treatment, improved life expectancy quality of children with perinatally-acquired human immunodeficiency virus (HIV) infection. There is increasing interest the chronic effects growing up HIV. The aim this study was to assess psychosocial, emotional behavioural functioning a cohort HIV-infected adolescents. Data were obtained through semi-structured interviews Strengths Difficulties Questionnaire (SDQ) for disorders screening. Results: A total 95 patients...
Abstract Introduction Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric Education Research (CIPHER) global project. Methods Data were collected between 1994 2015 11 CIPHER networks worldwide. perinatally acquired infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, at least one height or count...
The AEP Immunization Calendar for 2024, with its immunization recommendations pregnant women, children and adolescents residing in Spain, marks the 25th edition since first one was introduced 1995, being annual 2003, as a vaccination calendar, 2023 schedule due to inclusion of monoclonal antibody prevention RSV disease. Novelties this year include following: Tables systematic immunizations healthy people those belonging risk groups. Although were previously made they have been now included...
The SARS-CoV-2 pandemic has caused an increase in antibiotic use different settings. We describe the prescribing prevalence, associated factors and trends, as well concomitant bacterial infections children hospitalized with COVID-19 or multisystemic inflammatory syndrome related to Spain.
Introduction. Many human immunodeficiency virus type 1 (HIV-1)-infected children have already failed treatment with 2 or even 3 classes of antiretrovirals. Coformulation lopinavir low dose ritonavir exhibits a potent antiretroviral effect. However, the data in heavily pretreated are still scarce. This study evaluated safety and effectiveness combination therapy including lopinavir/ritonavir prior exposure to all oral Methods. was an open label multicenter observational study, which were...
The expanded use of long-term antiretroviral treatments in infected children may exacerbate the problem drug resistance mutations selection, which can compromise treatment efficiency.We describe temporal trends HIV and HIV-1 variants during 23 years (1993 to March 2016) Madrid cohort HIV-infected adolescents.We selected patients with at least one available pol sequence/genotypic profile, establishing different groups according sampling year first data. We determined prevalence transmitted or...
Background: Several evidence-based guidelines for the management of children with febrile neutropenia (FN) have been published, special focus in bacterial and fungal infections. However, role acute respiratory infections caused by viruses (RV) has not clearly established. The aim this study was to evaluate epidemiology, clinical presentation outcome FN. Methods: Patients, <18 years age admitted Pediatric Oncology-Hematology Unit after developing FN between November 2010 December 2013,...
We evaluated the effectiveness and safety of direct-acting antivirals in adolescents with hepatitis C (HCV)/HIV coinfection using pooled individual patient-level data from 5 European cohorts. Of 122 participants follow-up November 2013 to August 2021, 19 were treated <18 years age; 15 HCV RNA available at/after 12 weeks post-treatment, all had sustained virologic response acceptable safety. This evidence addresses an important gap knowledge treatment outcomes HCV/HIV real-life settings.
Abstract Background Although integrase inhibitor (INI)-based regimens are now the first-line choice for all people living with HIV, experience among children and adolescents is still scarce. We describe characteristics outcomes of a paediatric/adolescent cohort on INI-based ART. Methods Retrospective analysis HIV-infected patients below 18 years age who started an regimen from 2007 to 2019, enrolled in Spanish National Adult (CoRIS) Paediatric (CoRISpe) cohorts. Resistance mutations were...
Antiretroviral treatment (ART) in children has special features and consequently, results obtained from clinical trials with antiretroviral drugs adults may not be representative of children. Nelfinavir (NFV) is an HIV-1 Protease Inhibitor (PI) which become as one the first choices PI for ART We studied during a 3-year follow-up period effects highly active therapy nelfinavir vertically infected Forty-two HIV-infected on HAART NFV were involved multicentre prospective study. The monitored at...
Acute Epstein-Barr virus (aEBV) and cytomegalovirus (CMV) infections frequently have similar manifestations. We aim to evaluate the characteristics of aEBV infection, risk factors for hospitalisation differences according CMV IgM detection (EBV-CMV co-detection) in children.Retrospective, single-centre study including patients <16 years diagnosed with infection (positive anti-EBV IgM/Paul-Bunnell test acute symptomatology). EBV-CMV co-detection was defined as positive IgM. Factors associated...
<title>Abstract</title> <bold>Purpose</bold> We evaluated the prevalence and characteristics of persistent signs and/or symptoms in children young people (CYP) one year after hospitalization for acute COVID-19 compared with a control group CYP hospitalized other conditions. <bold>Methods</bold> conducted an observational study three hospitals Madrid. included who aged 1 month to 18 years age were from March 2020 December 2021. selected patients comparison among same as participants COVID-19,...
Background: We evaluated the prevalence and characteristics of persistent signs and/or symptoms in children young people (CYP) one year after hospitalization for acute COVID-19 compared with a control group CYP hospitalized other conditions. Methods: conducted an observational study three hospitals Madrid, which included aged between 1 month 18 years who were due to from March 2020 December 2021. also selected comparison patients other, unrelated conditions within same month. Eligible...