A5056422504- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Gestational Diabetes Research and Management
- Adolescent and Pediatric Healthcare
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pneumocystis jirovecii pneumonia detection and treatment
- Pregnancy and preeclampsia studies
- Biotin and Related Studies
- Bone and Joint Diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Diabetes and associated disorders
- Vitamin D Research Studies
- Viral Infections and Immunology Research
- Pharmacological Effects and Toxicity Studies
- Mobile Health and mHealth Applications
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Myasthenia Gravis and Thymoma
- Syphilis Diagnosis and Treatment
- Advanced Causal Inference Techniques
- SARS-CoV-2 detection and testing
Harvard University
2014-2024
Cancer Research And Biostatistics
2012-2024
Michigan State University
2024
Sparrow Hospital
2024
Shreemati Nathibai Damodar Thackersey Women's University
2024
Ascension Providence Hospital
2023
Brigham and Women's Hospital
2021
Tata Medical Center
2020
University of Findlay
2018
University of Miami
2013-2016
Advances in therapy have allowed children with perinatal HIV infection the United States to survive into adolescence. We sought describe disease status of a large cohort such and identify predictors their current CD4 count viral load (VL).The Pediatric HIV/AIDS Cohort Study AMP Protocol is an ongoing prospective study conducted at 15 sites States. Between 2007 2009, we enrolled population-based sample 451 who were 7-16 years age entry.The median subjects entry was 12.2 years, 53% female, 70%...
To estimate prevalence of low bone mineral density (BMD) in perinatally HIV-infected (HIV+) and HIV-exposed but uninfected (HEU) children, to determine predictors BMD HIV+.Cross-sectional analysis within a 15-site United States Puerto Rico cohort study.Total body lumbar spine were measured using dual energy-X-ray absorptiometry. Z-scores accounted for age sex. Multiple linear regression was used evaluate differences by HIV status HIV+.350 HIV+ 160 HEU enrolled. Mean 12.6 10.7 years HEU,...
Objectives HIV‐infected children may be at risk for premature cardiovascular disease. We compared levels of biomarkers vascular dysfunction in HIV ‐infected (with and without hyperlipidaemia) with those ‐exposed, uninfected ( HEU ) enrolled the P ediatric HIV/AIDS C ohort S tudy PHACS ), determined factors associated these biomarkers. Methods A prospective cohort study was carried out. Biomarkers inflammation [ ‐reactive protein CRP interleukin‐6 IL ‐6) monocyte chemoattractant protein‐1...
<i>Background/Aims:</i> Because of prior inconsistent findings, we studied a large cohort HIV-infected children to determine: (1) prevalence insulin resistance (IR); (2) anthropometric and clinical correlates IR, (3) concomitant abnormalities glucose tolerance. <i>Methods:</i> The study population consisted 451 from the Pediatric HIV/AIDS Cohort Study. outcome interest was HOMA-IR. Covariates included demographic, metabolic, growth, body composition, HIV laboratory...
Data on the effectiveness and safety of dolutegravir-based antiretroviral therapy (ART) for human immunodeficiency virus type 1 (HIV-1) infection in pregnancy as compared with other ART regimens commonly used United States Europe, particularly when initiated before conception, are limited.We conducted a study involving pregnancies persons HIV-1 Pediatric HIV/AIDS Cohort Study whose initial included dolutegravir, atazanavir-ritonavir, darunavir-ritonavir, oral rilpivirine, raltegravir, or...
Previous studies of cardiomyopathy among children perinatally infected with HIV were conducted before the routine use HAART. Nucleoside analogs [nucleoside reverse transcriptase inhibitors (NRTIs)], backbone HAART, have been associated mitochondrial toxicity, which can lead to cardiomyopathy. We evaluated association HAART and specific NRTIs on development HIV-infected children.Three thousand thirty-five enrolled in a US-based multicenter prospective cohort study followed for cardiomyopathy,...
The CD4 cell count or percent (CD4%) at the start of combination antiretroviral therapy (cART) is an important prognostic factor in children starting and indicator program performance. We describe trends determinants measures cART initiation from low-, middle-, high-income countries.We included aged <16 years clinics participating a collaborative study spanning sub-Saharan Africa, Asia, Latin America, United States. Missing values were estimated through multiple imputation. Severe...
Perinatally HIV-infected adolescents may be susceptible to aggregate atherosclerotic cardiovascular disease risk, as measured by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) coronary arteries and abdominal aorta risk scores, a result prolonged exposure HIV antiretroviral therapy.Coronary PDAY scores were calculated for 165 perinatally adolescents, using weighted combination modifiable factors: dyslipidemia, cigarette smoking, hypertension, obesity, hyperglycemia....
Background. The International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) P1060 study demonstrated short-term superiority of lopinavir/ritonavir (LPV/r) over nevirapine (NVP) in antiretroviral therapy (ART), regardless prior NVP exposure. However, NVP-based ART had a marginal benefit CD4 percentage (CD4%) and growth. We compared 5-year outcomes from this clinical trial. Methods. Human immunodeficiency virus (HIV)–infected, ART-eligible children were enrolled into 2...
Early antiretroviral therapy (ART) limits proviral reservoirs, a goal for human immunodeficiency virus type 1 (HIV-1) remission strategies. Whether this is an immediate or long-term effect of virologic suppression (VS) in perinatal infection unknown. We quantified HIV-1 DNA longitudinally up to 14 years peripheral blood mononuclear cells (PBMCs) among 61 perinatally HIV-1–infected youths the Pediatric HIV/AIDS Cohort Study who achieved VS at different ages. Participants group (n = 13) were...
To evaluate the association between HIV infection and sexual maturation, mediation of this by effects on growth.
BackgroundComputer simulation models can project long-term patient outcomes and inform health policy. We internally validated then calibrated a model of HIV disease in children before initiation antiretroviral therapy to provide framework against which compare the impact pediatric treatment strategies. MethodsWe developed patient-level (Monte Carlo) progression among untreated <5 years age, using Cost-Effectiveness Preventing AIDS Complications framework: CEPAC-Pediatric model. populated...
Background. Children with perinatal human immunodeficiency virus (HIV) infection (PHIV) may not be protected against measles, mumps, and rubella (MMR) because of impaired initial vaccine response or waning immunity. Our objectives were to estimate seroimmunity in PHIV-infected perinatally HIV-exposed but uninfected (HEU) children identify predictors immunity the PHIV cohort. Methods. HEU enrolled Pediatric HIV/AIDS Cohort Study (PHACS) at ages 7–15 years from 2007 2009. At annual visits,...
Abstract Background Persons who are infected with human immunodeficiency virus (HIV) at high risk of papillomavirus (HPV)-associated cancers. The objectives to compare antibody titers HPV 6, 11, 16, and 18 rate abnormal cytology between perinatally HIV-infected (PHIV) HIV-exposed, uninfected (PHEU) youth. Methods This is a prospective observational cohort study HPV4 vaccinated youth performed as part the multicenter Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol. Seroconversion...
The first generation of adolescents born with HIV infection has reached young adulthood due to advances in treatment. It is important continue follow-up these individuals assess their long-term medical, behavioural and mental health ability successfully transition while coping a chronic, potentially stigmatising condition. To accomplish this, maintain interest research participation, we need accommodate the changing lifestyles interests adult study participants ensuring valid data...
Background: Abnormal childhood growth may affect future health. Maternal tenofovir (TFV) use was associated with lower body length and head circumference at 1 year of age in HIV-exposed uninfected (HEU) US children. Methods: We studied 509 HEU children the US-based Surveillance Monitoring Antiretroviral Therapy Toxicities cohort whose HIV-infected mothers were not using antiretrovirals last menstrual period began combination antiretroviral therapy (cART) pregnancy (cART initiators). examined...
Objective: Bictegravir is increasingly prescribed as a co-formulated tablet with tenofovir alafenamide and emtricitabine to pregnant persons HIV (PWH) despite limited pregnancy birth outcome data. We sought provide data following exposure bictegravir during pregnancy. Design: conducted descriptive analysis of infants born PWH 18–45 years age enrolled in at least one Pediatric HIV/AIDS Cohort Study (PHACS)-affiliated study who received for ≥7 days completed follow-up through delivery....
To compare prevalence of insulin resistance between perinatally HIV-infected (PHIV+) and HIV-exposed, but uninfected adolescents (PHEU), determine incidence contributory factors to new resolved cases in PHIV+, evaluate glucose metabolism.Cross-sectional design for comparison among PHIV+ PHEU. Longitudinal resolution at risk these outcomes.The source population was from pediatric HIV clinics the United States Puerto Rico participating Pediatric HIV/AIDS Cohort Study, an ongoing prospective...
Young adults with perinatally acquired HIV (YPHIVs) living in the United States are transitioning to adult clinical care, yet there is little information on factors that affect transition outcomes.YPHIVs aged ≥18 years Pediatric HIV/AIDS Cohort Study (PHACS) AMP Up cohort approaching or having completed from pediatric healthcare were included. Demographic and characteristics self-reported ability self-manage compared by status, multivariable logistic regression models examined associated...
Abstract Introduction Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric Education Research (CIPHER) global project. Methods Data were collected between 1994 2015 11 CIPHER networks worldwide. perinatally acquired infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, at least one height or count...
To assess the characteristics and outcomes of antiretroviral treatment (ART) interruption (TI) in perinatally HIV-infected children.The Adolescent Master Protocol (AMP) Pediatric HIV/AIDS Cohort Study is a prospective cohort study that enrolled 7- to 16-year-old children between 2007 2009 from 15 sites United States Puerto Rico.TI was defined as ART discontinuation for ≥ 3 months after 6 continuous ART. Subjects with without TI were compared. Rates change (slopes) CD4 T-lymphocyte (CD4)...
As young adults living with perinatal HIV (PHIV) or exposure but uninfected (PHEU) grow older and manage the challenges competing demands of adulthood, new approaches are needed to facilitate their retention in longitudinal research clinical care beyond in-person clinic visits. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), novel virus that causes disease (COVID-19), emerged United States January 2020 has underscored this need; studies adapting remote communication data...