A5044125326- Turfgrass Adaptation and Management
- Plant and fungal interactions
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Plant Disease Management Techniques
- HIV/AIDS drug development and treatment
- Rangeland and Wildlife Management
- Plant Pathogens and Fungal Diseases
- HIV-related health complications and treatments
- Plant and Fungal Interactions Research
- Bioenergy crop production and management
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Plant pathogens and resistance mechanisms
- Agriculture, Soil, Plant Science
- Hepatitis B Virus Studies
- Botanical Research and Chemistry
- Plant Disease Resistance and Genetics
- Hepatitis C virus research
- SARS-CoV-2 detection and testing
- Seedling growth and survival studies
- Plant Taxonomy and Phylogenetics
- Berry genetics and cultivation research
- HIV, Drug Use, Sexual Risk
- Ruminant Nutrition and Digestive Physiology
Quest Diagnostics (United States)
2013-2025
Rutgers, The State University of New Jersey
2015-2025
Oregon State University
2022-2023
Gilead Sciences (Australia)
2022
Stanford University
1994-2022
Beijing Forestry University
2022
Syngenta (United States)
2022
E Ink (South Korea)
2022
VA Palo Alto Health Care System
2022
Alameda County Public Health Department
2022
Maternal, obstetrical, and infant-related factors associated with the risk of perinatal transmission human immunodeficiency virus type 1 (HIV-1) were identified before widespread use zidovudine therapy in pregnant women. The for when women infants receive are not well characterized.
Regimens containing three nucleoside reverse-transcriptase inhibitors offer an alternative to regimens nonnucleoside or protease for the initial treatment of human immunodeficiency virus type 1 (HIV-1) infection, but data from direct comparisons are limited.
Case-based surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection likely underestimates the true prevalence infections. Large-scale seroprevalence surveys can better estimate across many geographic regions.To persons with SARS-CoV-2 antibodies using residual sera from commercial laboratories US and assess changes over time.This repeated, cross-sectional study conducted all 50 states, District Columbia, Puerto Rico used a convenience sample serum specimens...
Understanding the effect of serum antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on susceptibility infection is important for identifying at-risk populations and could have implications vaccine deployment.
Association of human immunodeficiency virus type 1 (HIV-1) RNA level, CD4 cell percent, and mortality was examined in stored sera from 254 infected children an intravenous immunoglobulin infection prophylaxis trial. Ninety-two (36.2%) died (41 during the study, 51 long-term follow-up). The geometric mean baseline HIV-1 level 104,626 copies/mL, percent 25%. Relative risk death (RR) 2.1 if > 100,000 copies/mL (95% confidence interval [CI], 1.4–3.0) 3.0 <15% CI, 2.2–4.0). If levels increased...
Journal Article Combination Therapy with Zidovudine and Didanosine Selects for Drug-Resistant Human Immunodeficiency Virus Type 1 Strains Unique Patterns of pol Gene Mutations Get access Robert W. Shafer, Shafer Reprints or correspondence: Dr. Center AIDS Research, Room S-156, Stanford University Medical Center, Stanford, CA 94305. Search other works by this author on: Oxford Academic PubMed Google Scholar Michael J. Kozal, Kozal Mark A. Winters, Winters Astrid K. N. Iversen, Iversen David...
Background. The clinical relevance of detecting minority drug-resistant human immunodeficiency virus type 1 (HIV-1) variants is uncertain. Methods. To determine the effect pre-existing nonnucleoside reverse-transcriptase inhibitor (NNRTI)-resistant on risk virologic failure, we reanalyzed a case-cohort substudy efavirenz recipients in AIDS Clinical Trials Group protocol A5095. Minority K103N or Y181C populations were determined by allele-specific polymerase chain reaction subjects without...
Objective: To determine if particular components of antiretroviral drug regimens are associated with greater insulin resistance, dyslipidemia, and peripheral lipoatrophy. Methods: Metabolic body composition variables were measured prospectively over 64 weeks in 334 antiretroviral-naive, HIV-infected subjects who randomized to receive nelfinavir, efavirenz, or both, combined zidovudine/lamivudine didanosine/stavudine a factorial design, multicenter trial. Subjects assigned efavirenz (n = 110)...
Quadrivalent human papillomavirus vaccine (QHPV) is > 95% effective in preventing infection with vaccine-type papillomavirus. The safety and immunogenicity of QHPV are unknown HIV-infected children.HIV-infected children (N = 126)-age 7 to < 12 years, a CD4% ≥ 15-and on stable antiretroviral therapy if was 25-were blindly assigned receive dose or placebo (3:1 ratio) at 0, 8, 24 weeks. Adverse events were evaluated after each dose. Serum antibody against antigens measured by competitive...
A case-cohort study was used to determine the effect of baseline nonnucleoside reverse-transcriptase inhibitor (NNRTI) resistance, as assessed by viral genotyping, on response efavirenz-containing regimens in AIDS Clinical Trials Group A5095. The sample included a random cohort efavirenz-treated subjects plus unselected who experienced virologic failure. Of 220 cohort, 57 (26%) had prevalence NNRTI resistance 5%. risk failure for with higher than that without such (hazard ratio 2.27 [95%...
The COVID-19 pandemic has disrupted healthcare services, reducing opportunities to conduct routine hepatitis C virus antibody screening, clinical care, and treatment. Therefore, people living with undiagnosed during the may later become identified at more advanced stages of disease, leading higher morbidity mortality rates. Further, unidentified virus-infected individuals continue unknowingly transmit others.
Sero-surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can reveal trends and differences in subgroups capture undetected or unreported infections that are not included case-based surveillance systems. Cross-sectional, convenience samples remnant sera from clinical laboratories 51 U.S. jurisdictions were assayed for infection-induced SARS-CoV-2 antibodies biweekly October 25, 2020, to July 11, 2021, monthly September 6, February 26, 2022. Test results analyzed...
Approximately 2.4 million adults were estimated to have hepatitis C virus (HCV) infection in the United States during 2013-2016 (1). Untreated, can lead advanced liver disease, cancer, and death (2). The Viral Hepatitis National Strategic Plan for calls ≥80% of persons with achieve viral clearance by 2030 (3). Characterizing steps that follow a person's progression from testing subsequent (clearance cascade) is critical monitoring progress toward national elimination goals. Following CDC...
Pediatric AIDS Clinical Trials Group protocol 185 evaluated whether zidovudine combined with human immunodeficiency virus (HIV) hyperimmune immunoglobulin (HIVIG) infusions administered monthly during pregnancy and to the neonate at birth would significantly lower perinatal HIV transmission compared treatment intravenous (IVIG) without antibody. Subjects had baseline CD4 cell counts ⩽500/μL (22% <200/μL) required for maternal health (24% received before pregnancy). Transmission was...
An essential prerequisite to cultivar identification is determine whether cultivars are differentiated genetically. We investigated genetic diversity among and within seven perennial ryegrass ( Lolium perenne L.) (Loretta, Linn, Manhattan II, Affinity, Jet, Pennfine, Palmer III) using simple sequence repeat (SSR) markers, with the goal of determining could be on basis data. In each we genotyped 30 individuals 22 SSR 18 which had not been reported previously. Our results indicated that...
Vitamin D deficiency is of increasing concern in HIV-infected persons because its reported association with a number negative health outcomes that are common HIV. We undertook this study to determine the prevalence and predictors vitamin among nationally representative cohort middle-aged, ethnically diverse, HIV-uninfected women enrolled Women's Interagency HIV Study (WIHS).Vitamin testing was performed by Quest Diagnostics on frozen sera using liquid chromatography/mass spectroscopy method....
Objective: To compare the distribution of lipid and glucose abnormalities altered fat among vertically HIV-infected patients controls. Design: Cross-sectional multicenter study on (HIV-positive) patients, 7–24 years age, stratified by Tanner stage protease inhibitor use (protease inhibitor, n = 161 non- 79) seronegative controls (HIV-negative, 146). Methods: Measurements included fasting lipids, glucose, insulin, 2-h oral tolerance test, dual-energy X-ray absorptiometry, anthropometry,...
Introduction We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in United States. Methods Serum and saliva samples from 176 vaccinated adults were collected October December 2021, immediately before wave, assessed for Spike-specific IgG IgA binding antibodies (bAb). Sera also bAb using commercial assays, neutralization activity several variants. PVI duration severity, as well risk...
Worldwide, 90% of HIV-1 infections are transmitted heterosexually. Because the genital mucosa sites initial contact with for most exposed individuals, study virus from tract is critical development vaccines and therapeutics. Previous analyses in various tissues have documented compartmentalization viral genomes. Whether was associated phenotypic differences or immune status, however, not well understood. We compared gp120 env sequences plasma 12 women. Eight women displayed compartmentalized...
Kentucky bluegrass ( Poa pratensis L.; KBG) has good turf quality with adequate irrigation, but moderate to low drought resistance. Interspecific hybridization of Texas arachnifera Torr.; TBG), a resistant grass native Texas, been made transfer genes resistance from TBG KBG. The objectives this study were (i) investigate whether the hybrids have improved compared either or KBG by examining physiological responses stress; and (ii) determine major factors associated recuperative ability those...