Simon Pollett
A5102870231- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Mosquito-borne diseases and control
- vaccines and immunoinformatics approaches
- Viral Infections and Vectors
- Influenza Virus Research Studies
- COVID-19 and healthcare impacts
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- COVID-19 and Mental Health
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Zoonotic diseases and public health
- Bacterial Identification and Susceptibility Testing
- Salmonella and Campylobacter epidemiology
- Bacillus and Francisella bacterial research
- Inflammasome and immune disorders
- Viral Infections and Immunology Research
- Tryptophan and brain disorders
- Biosensors and Analytical Detection
- Ocular Infections and Treatments
Uniformed Services University of the Health Sciences
2021-2025
Henry M. Jackson Foundation
2021-2025
Unifor
2023-2024
Jackson Foundation
2023
Walter Reed Army Institute of Research
2021-2022
United States Naval Medical Research Unit SOUTH
2012-2020
Westmead Hospital
2015
The University of Sydney
2014
Royal Prince Alfred Hospital
2013
The rapid spread of the highly contagious Omicron variant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) along with its high number mutations in spike gene has raised alarms about effectiveness current medical countermeasures. To address this concern, we measured neutralization BA.1 pseudovirus by postvaccination serum samples after two and three immunizations Pfizer/BioNTech162b2 SARS-CoV-2 mRNA (Pfizer/BNT162b2) vaccine, convalescent from unvaccinated individuals infected...
Importance Understanding the factors associated with post-COVID conditions is important for prevention. Objective To identify characteristics persistent post–COVID-19 symptoms and to describe medical encounters. Design, Setting, Participants This cohort study used data from Epidemiology, Immunology, Clinical Characteristics of Emerging Infectious Diseases With Pandemic Potential (EPICC) implemented in US military health system (MHS); MHS beneficiaries aged 18 years or older who tested...
Abstract Background The relationship between postvaccination symptoms and strength of antibody responses is unclear. goal this study was to determine whether adverse effects caused by vaccination with the Pfizer/BioNTech BNT162b2 vaccine are associated magnitude vaccine-induced levels. Methods We conducted a single-center, observational cohort consisting generally healthy adult participants that were not severely immunocompromised, had no history coronavirus disease 2019, seronegative for...
The SARS-CoV-2 pandemic prompts evaluation of recombination in human coronavirus (hCoV) evolution. We undertook analyses 158,118 public seasonal hCoV, SARS-CoV-1, and MERS-CoV genome sequences using the RDP4 software. found moderate evidence for 8 events, two which involved spike gene, low one SARS-CoV-1 event. Within MERS-CoV, 229E, OC43, NL63 HKU1 datasets, we noted 7, 1, 9, 14, 1 high-confidence respectively. There was propensity breakpoints non-ORF1 region containing structural genes,...
Abstract Background Comparison of humoral responses in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinees, those with SARS-CoV-2 infection, or combinations vaccine/ infection (“hybrid immunity”) may clarify predictors vaccine immunogenicity. Methods We studied 2660 US Military Health System beneficiaries a history infection-alone (n = 705), vaccination-alone 932), vaccine-after-infection 869), and vaccine-breakthrough-infection 154). Peak anti-spike–immunoglobulin G (IgG)...
ABSTRACT Introduction Vaccine mandates have been used to minimize the duty days lost and deaths attributable infectious disease among active Service members (ADSMs). In response global COVID-19 pandemic, in August 2021, U.S. DoD issued a vaccine mandate for all ADSMs. This study aimed investigate uptake ADSM population, as well factors associated with timing of receipt. Materials Methods included ADSMs on between January 1, 2020, June 30, 2022. Univariate analyses investigated associations...
Introduction We sought to determine pre-infection correlates of protection against SARS-CoV-2 post-vaccine inzfections (PVI) acquired during the first Omicron wave in United States. Methods Serum and saliva samples from 176 vaccinated adults were collected October December 2021, immediately before wave, assessed for Spike-specific IgG IgA binding antibodies (bAb). Sera also bAb using commercial assays, neutralization activity several variants. PVI duration severity, as well risk...
Campylobacter jejuni and coli are food-borne pathogens of great importance feature prominently in the etiology developing world enteritis travellers' diarrhoea. Increasing antimicrobial resistant prevalence has been described globally, yet data from Peru is limited. Our objective was to describe trends fluoroquinolone macrolide-resistant C. stool isolates three regions over a ten-year period. Surveillance for enteric conducted Lima, Iquitos Cusco between 2001 2010. were tested...
The rapid spread of the highly contagious Omicron variant SARS-CoV-2 along with its high number mutations in spike gene has raised alarm about effectiveness current medical countermeasures. To address this concern, we measured neutralizing antibodies against three important settings: (1) post-vaccination sera after two and immunizations Pfizer/BNT162b2 vaccine, (2) convalescent from unvaccinated individuals infected by different variants, (3) clinical-stage therapeutic antibodies. Using a...
Abstract Little is known about severe acute respiratory syndrome coronavirus 2 “vaccine-breakthrough” infections (VBIs). Here we characterize 24 VBIs in predominantly young healthy persons. While none required hospitalization, a proportion endorsed symptoms and shed live virus as high 4.13 × 103 plaque-forming units/mL. Infecting genotypes included both variant-of-concern (VOC) non-VOC strains.
Sensitive and specific SARS-CoV-2 antibody assays remain critical for community hospital-based sero-surveillance. With the rollout of vaccines, such must be able to distinguish vaccine from natural immunity related human coronaviruses. Here, we developed implemented multiplex microsphere-based immunoassay strategies COVD-19 studies that incorporates spike protein trimers endemic seasonal coronaviruses (HCoV), enabling high throughout measurement pre-existing cross-reactive antibodies. We...
Characterizing the longevity and quality of cellular immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enhances understanding disease 2019 (COVID-19) immunity that influences clinical outcomes. Prior studies suggest SARS-CoV-2-specific T cells are present in peripheral blood 10 months after infection. Analysis function, durability, diversity response long natural infection, over a range ages phenotypes, is needed identify preventative therapeutic...
This phase 3 trial assessed AZD7442 (tixagevimab/cilgavimab) for post-exposure prophylaxis against symptomatic coronavirus disease 2019 (COVID-19).Adults without prior severe acute respiratory syndrome 2 (SARS-CoV-2) infection or COVID-19 vaccination were enrolled within 8 days of exposure to a SARS-CoV-2-infected individual and randomized 2:1 single 300-mg dose (one 1.5-mL intramuscular injection each tixagevimab cilgavimab) placebo. Primary end points safety first post-dose SARS-CoV-2...
Abstract We compared neutralizing antibody responses to BA.4/5, BQ.1.1, XBB, and XBB.1.5 Omicron severe acute respiratory syndrome coronavirus 2 variants after a bivalent or ancestral disease 2019 (COVID-19) messenger RNA booster vaccine postvaccination infection. found that the elicited moderately high titers against BA.4/5 were approximately 2-fold higher all than by monovalent booster. The low but similar both XBB variants. These findings inform risk assessments for future COVID-19...
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires ongoing monitoring to judge the ability newly arising variants escape immune response. A surveillance system necessitates an understanding differences in neutralization titers measured different assays and using human animal serum samples. We compared 18 datasets generated human, hamster, mouse six assays. Datasets model samples showed higher titer magnitudes than this comparison. Fold change ancestral...
Background Chronic neuropsychological sequelae following SARS-CoV-2 infection, including depression, anxiety, fatigue, and general cognitive difficulties, are a major public health concern. Given the potential impact of long-term impairment, it is important to characterize frequency predictors this post-infection phenotype. Methods The Epidemiology, Immunology, Clinical Characteristics Emerging Infectious Diseases with Pandemic Potential (EPICC) study longitudinal assessing infection in U.S....
Abstract Background T cells are associated with viral clearance and improved outcomes in COVID-19, but also immunopathology. Defining cell diversity response to SARS-CoV-2 infection enables implementation of prevention treatment strategies. recognize peptide sequences from pathogens upon presentation major histocompatibility complexes (MHC). Human MHC molecule results a wide array recognition by making escape difficult, challenging measure. Methods Using the ImmunoSEQ Assay sequence...
Abstract Background Post-COVID conditions (PCC, ‘Long COVID’) remain a military health concern, and symptom heterogeneity limits understanding of PCC pathogenesis. To address this, we used machine learning to define phenotypes in Military Health System (MHS) beneficiaries. Here, extend these findings identify early transcriptomic profiles which may predict the development distinct symptom-based phenotypes. (A) Machine techniques identified three groups participants based on chronic...
Abstract Background SARS-CoV-2 myocarditis is a rare but serious complication of COVID-19. The host response correlates remain unclear, thereby limiting therapeutic development. We therefore performed proteomic and transcriptomic phenotyping in Military Health System (MHS) beneficiaries. included bioenergetics focus given the emerging role mitochondrial function enteroviral myocarditis. Early (<30 days post infection) plasma biomarkers measured by Ella 20-plex ELISA assay cases...
Abstract Background Characterizing influenza outbreaks among vaccinated populations may support optimization of prevention. We used a surveillance study at the United States Naval Academy (USNA) to characterize epidemiology, phenotype, and phylogeny recent A/H3N2 outbreak midshipmen (undergraduate students). Figure 1 1A: Influenza case counts USNA Midshipmen Staff Evaluated in February 2024. Day refers collection time first clonal sequence. ‘Mitigation strategies implemented’ included...
We evaluated clinical outcomes, functional burden, and complications 1 month after coronavirus disease 2019 (COVID-19) infection in a prospective US Military Health System (MHS) cohort of active duty, retiree, dependent populations using serial patient-reported outcome surveys electronic medical record (EMR) review.MHS beneficiaries presenting at 9 sites across the United States with positive severe acute respiratory syndrome 2 (SARS-CoV-2) test, COVID-19-like illness, or high-risk...
ABSTRACT Importance The persistence of SARS-CoV-2 antibodies may be a predictive correlate protection for both natural infections and vaccinations. Identifying predictors robust antibody responses is important to evaluate the risk re-infection / vaccine failure translatable effectiveness. Objective To 1) determine durability anti-SARS-CoV-2 IgG neutralizing in subjects who experienced mild moderate severe COVID-19, 2) correlation age endemic human seasonal coronaviruses (HCoVs) according...