A5075963361- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Asthma and respiratory diseases
- Child Nutrition and Water Access
- Fecal contamination and water quality
- Diabetes Management and Education
- Urticaria and Related Conditions
- Respiratory and Cough-Related Research
- Vector-borne infectious diseases
- Vibrio bacteria research studies
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- COVID-19 epidemiological studies
- Antibiotic Use and Resistance
- Sinusitis and nasal conditions
- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmaceutical studies and practices
- Diabetes Management and Research
- Global Maternal and Child Health
- Dermatology and Skin Diseases
- Influenza Virus Research Studies
- Autoimmune Bullous Skin Diseases
Universidade do Porto
2025
Iberoamerican Cochrane Centre
2020-2024
Institut de Recerca Sant Pau
2023
Hospital de Sant Pau
2023
Biomedical Research Institute
2020-2021
United States Naval Medical Research Unit SOUTH
2011-2020
Prisma
2011-2018
Universidad Peruana Cayetano Heredia
2011-2018
Centers for Disease Control and Prevention
2015
Ministry of Health
2015
Background Arthropod-borne viruses (arboviruses) are among the most common agents of human febrile illness worldwide and important emerging pathogens, causing multiple notable epidemics disease over recent decades. Despite public health relevance, little is know about geographic distribution, relative impact, risk factors for arbovirus infection in many regions world. Our objectives were to describe arboviruses associated with acute undifferentiated participating clinics four countries South...
Background Comprehensive, longitudinal field studies that monitor both disease and vector populations for dengue viruses are urgently needed as a pre-requisite developing locally adaptable prevention programs or to appropriately test license new vaccines. Methodology Principal Findings We report the results from such study spanning 5 years in Amazonian city of Iquitos, Peru where DENV infection was monitored serologically among ∼2,400 members neighborhood-based cohort through school-based...
Background. Antibodies induced by infection with any 1 of 4 dengue virus (DENV) serotypes (DENV-1–4) may influence the clinical outcome subsequent heterologous infections. To quantify potential cross-protective effects, we estimated disease risk as a function DENV infection, using data from longitudinal studies performed September 2006 through February 2011 in Iquitos, Peru, during periods DENV-3 and DENV-4 transmission. Methods. infections before study period were determined analysis serial...
Significance Using mathematical models to extend knowledge of pathogen transmission and recommend optimized control efforts is dependent on the accuracy model parameters. The rate at which susceptible individuals become infected [the force infection (FoI)] one most important parameters, but due data constraints it often incorrectly assumed be constant over time. a bespoke method for 12-y longitudinal dataset serotype-specific dengue virus (DENV) infections, we estimated time-varying, FoIs...
Tuberculosis (TB) affected households in impoverished shantytowns, Lima, Peru.
Introduction Long-term disease surveillance data provide a basis for studying drivers of pathogen transmission dynamics. Dengue is mosquito-borne caused by four distinct, but related, viruses (DENV-1-4) that potentially affect over half the world's population. incidence varies seasonally and on longer time scales, presumably driven interaction climate host susceptibility. Precise understanding dengue dynamics constrained, however, relative paucity laboratory-confirmed longitudinal data....
Background Acute respiratory illnesses and influenza-like (ILI) are a significant source of morbidity mortality worldwide. Despite the public health importance, little is known about etiology these acute in many regions South America. In 2006, Peruvian Ministry Health (MoH) US Naval Medical Research Center Detachment (NMRCD) initiated collaboration to characterize viral agents associated with ILI describe clinical epidemiological presentation affected population. Methodology/Principal...
Background Knowledge of spatial patterns dengue virus (DENV) infection is important for understanding transmission dynamics and guiding effective disease prevention strategies. Because movement infected humans mosquito vectors plays a role in the spread persistence virus, dimensions can range from small household foci to large community clusters. Current limited because past analyses emphasized clinically apparent illness did not account potentially proportion inapparent infections. In this...
Background Dengue virus (DENV) infection can range in severity from mild dengue fever (DF) to severe hemorrhagic (DHF) or shock syndrome (DSS). Changes host gene expression, temporally through the progression of DENV infection, especially during early days, remains poorly characterized. Early diagnostic markers for DHF are also lacking. Methodology/Principal Findings In this study, we investigated expression a cohort DENV-infected subjects clinically diagnosed as DF (n = 51) and 13) Maracay,...
Campylobacter jejuni and coli are food-borne pathogens of great importance feature prominently in the etiology developing world enteritis travellers' diarrhoea. Increasing antimicrobial resistant prevalence has been described globally, yet data from Peru is limited. Our objective was to describe trends fluoroquinolone macrolide-resistant C. stool isolates three regions over a ten-year period. Surveillance for enteric conducted Lima, Iquitos Cusco between 2001 2010. were tested...
The indicator used to measure progress toward the Millennium Development Goal (MDG) for water is access an improved supply. However, supplies are frequently fecally contaminated in developing countries. We examined factors associated with Escherichia coli contamination of rural Pisco province, Peru. A random sample 207 households at least one child less than 5 years old was surveyed, and samples from source storage container were tested E. contamination. Although over 90% source, 47% 43%...
In 2008, dengue virus serotype 4 (DENV-4) emerged in northeastern Peru, causing a large outbreak and displacing DENV-3, which had predominated for the previous 6 years. Phylogenetic analysis of 2008 2009 isolates support their inclusion into DENV-4 genotype II, forming lineage distinct from strains that previously circulated region.
Enzootic strains of Venezuelan equine encephalitis virus (VEEV) have been isolated from febrile patients in the Peruvian Amazon Basin at low but consistent levels since early 1990s. Through a clinic-based surveillance program, we detected an outbreak VEEV infections Iquitos, Peru, first half 2006. The majority these resided within urban areas with no report recent travel outside city. To characterize risk factors for infection city, antibody prevalence study was carried out geographically...
Although encephalomyocarditis virus (EMCV) infection has been commonly documented among domestic animals, less is known about EMCV transmission humans. Recently, we described the isolation of from two febrile patients in Peru. To further investigate Peru, screened reporting to health clinics Peru for serological evidence recent infection. We also conducted a survey EMCV-neutralizing antibodies city Iquitos, located Amazon basin department Loreto, Additionally, serum rodents collected 10...
Abstract Secondary dengue viral infection can produce capillary leakage associated with increased mortality known as hemorrhagic fever (DHF). Because the of DHF be reduced by early detection and intensive support, improved methods for its are needed. We applied multidimensional protein profiling to predict outcomes in a prospective surveillance study South America. Plasma samples taken from initial clinical presentation acute were subjected proteomics analyses using ELISA recently developed...
Endemic dengue transmission has been documented in the Amazonian city of Iquitos, Peru, since early 1990s. To better understand epidemiology we established multiple active surveillance systems to detect symptomatic infections. Here compare efficacy distinct community-based (door door) and school absenteeism-based febrile strategies detecting cases dengue. Febrile episodes were detected by both with equal rapidity after disease onset. However, during period that programs running...
To conduct an evidence map on self-management interventions and patient-relevant outcomes for adults living with overweight/obesity.Following Arksey O'Malley methodology, we searched in five electronical databases including randomized controlled trials (RCTs) SMIs overweight/obesity. We used the terms "self-management", "adult" "obesity" content. Two independent reviewers assessed eligible references; one reviewer extracted data, a second checked accuracy.We identified 497 RCTs (58% US, 20%...
Abstract Objectives Mobile phone interventions have been advocated for tuberculosis care, but little is known about access of target populations to mobile phones. We studied among patients with tuberculosis, focusing on vulnerable and who later had adverse treatment outcomes. Methods In a prospective cohort study in Callao, Peru, we recruited interviewed 2584 between 2007 2013 followed them until 2016 outcomes using national registers. Subsequently, further 622 2017. Data were analysed...