A5036534790- Mosquito-borne diseases and control
- Malaria Research and Control
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Insect symbiosis and bacterial influences
- Dengue and Mosquito Control Research
- Insect Pest Control Strategies
- Zoonotic diseases and public health
- Auditing, Earnings Management, Governance
- Financial Reporting and Valuation Research
- Corporate Finance and Governance
- Insect and Pesticide Research
- Financial Markets and Investment Strategies
- Insect behavior and control techniques
- Insect Resistance and Genetics
- Insect Utilization and Effects
- Human Mobility and Location-Based Analysis
- Viral Infections and Outbreaks Research
- Vector-Borne Animal Diseases
- Primate Behavior and Ecology
- Vector-borne infectious diseases
- Mathematical and Theoretical Epidemiology and Ecology Models
- CRISPR and Genetic Engineering
- Evolution and Genetic Dynamics
- Species Distribution and Climate Change
University of California, Davis
2014-2023
Atomic Weapons Establishment
1955-2023
Auckland University of Technology
2021
Geisinger Medical Center
2021
United States Naval Medical Research Unit SOUTH
2009-2020
San Diego State University
2003-2020
Emory University
2010-2020
University of Washington
2020
University of Sussex
2020
Tulane University
2020
Dengue and chikungunya are increasing global public health concerns due to their rapid geographical spread disease burden. Knowledge of the contemporary distribution shared vectors, Aedes aegypti albopictus remains incomplete is complicated by an ongoing range expansion fuelled increased trade travel. Mapping these vectors determinants ranges essential for planning. Here we compile largest database both species pair it with relevant environmental variables predicting distribution. We show...
Dengue is a growing problem both in its geographical spread and intensity, yet current global distribution remains highly uncertain. Challenges diagnosis diagnostic methods as well variable national health systems mean no single data source can reliably estimate the of this disease. As such, there lack agreement on dengue status among international organisations. Here we bring together all available information occurrence using novel approach to produce an evidence consensus map disease...
Abstract The global population at risk from mosquito-borne diseases—including dengue, yellow fever, chikungunya and Zika—is expanding in concert with changes the distribution of two key vectors: Aedes aegypti albopictus . these species is largely driven by both human movement presence suitable climate. Using statistical mapping techniques, we show that patterns explain spread Europe United States following their introduction. We find Ae. characterized long distance importations, while has...
Abstract Dengue is a mosquito-borne viral infection that has spread throughout the tropical world over past 60 years and now affects half world’s population. The geographical range of dengue expected to further expand due ongoing global phenomena including climate change urbanization. We applied statistical mapping techniques most extensive database case locations date predict environmental suitability for virus as 2015. then made use climate, population socioeconomic projections 2020, 2050...
Vaccine efficacy (VE) estimates are crucial for assessing the suitability of dengue vaccine candidates public health implementation, but trials subject to a known bias estimate VE toward null if heterogeneous exposure is not accounted in analysis trial data. In light many well-characterized sources heterogeneity virus (DENV) transmission, our goal was potential magnitude this hypothetical vaccine. To ensure that we realistically modeled exposure, simulated city-wide DENV transmission and...
Most studies on the ability of insect populations to transmit pathogens consider only constant temperatures and do not account for realistic daily temperature fluctuations that can impact vector-pathogen interactions. Here, we show diurnal range (DTR) affects two important parameters underlying dengue virus (DENV) transmission by Aedes aegypti. In independent experiments using different DENV serotypes, mosquitoes were less susceptible infection died faster under larger DTR around same mean...
Knowledge of mosquito dispersal is critical for vector-borne disease control and prevention strategies understanding population structure pathogen dissemination. We determined Aedes aegypti flight range patterns from 21 mark-release-recapture experiments conducted over 11 years (1991-2002) in Puerto Rico Thailand. Dispersal was compared by release location, sex, age, season, village. For all experiments, the majority mosquitoes were collected their house or adjacent house. Inter-village...
To identify the mosquito species competent for West Nile virus (WNV) transmission, we evaluated 10 California that are known vectors of other arboviruses or major pests: Culex tarsalis, Cx. pipiens pipiens, p. quinquefasciatus, stigmatosoma, erythrothorax, Ochlerotatus dorsalis, Oc. melanimon, sierrensis, Aedes vexans, and Culiseta inornata. All became infected were able to transmit WNV at some level. Ochlerotatus, Culiseta, low moderately efficient vectors. They feed primarily on mammals...
Ronald Ross and George Macdonald are credited with developing a mathematical model of mosquito-borne pathogen transmission. A systematic historical review suggests that several mathematicians scientists contributed to development the Ross-Macdonald over period 70 years. developed two different models, third, various “Ross-Macdonald” models exist. best defined by consensus set assumptions. The is just one part theory for dynamics control mosquito-transmitted pathogens also includes...
Human movement is a key behavioral factor in many vector-borne disease systems because it influences exposure to vectors and thus the transmission of pathogens. transcends spatial temporal scales with different on dynamics. Here we develop conceptual model evaluate importance variation due individual human movements for pathogen transmission, focusing mosquito-borne dengue virus.We showing that relevance at particular scale depends vector behavior. Focusing day-biting Aedes aegypti,...
Dengue is a mosquito-borne disease of growing global health importance. Prevention efforts focus on mosquito control, with limited success. New insights into the spatiotemporal drivers dengue dynamics are needed to design improved disease-prevention strategies. Given restricted range movement primary vector, Aedes aegypti, local human movements may be an important driver virus (DENV) amplification and spread. Using contact-site cluster investigations in case-control design, we demonstrate...
We used a histologic technique to study multiple blood feeding in single gonotrophic cycle by engorged Aedes aegypti (L.) that were collected weekly for 2 yr from houses rural village Thailand (n = 1,891) and residential section of San Juan, Puerto Rico 1,675). Overall, mosquitoes contained significantly more meals 1,300, 42% double meals, 5% triple meals) than 1,156, 32% 2% meals). The portion specimens which frequency could not be determined was 31% at both sites. estimated on average Ae....
The survival of adult female Aedes mosquitoes is a critical component their ability to transmit pathogens such as dengue viruses. One the principal determinants temperature, which has been associated with seasonal changes in populations and limits geographical distribution. effects temperature other sources mortality have studied field, often via mark-release-recapture experiments, under controlled conditions laboratory. Survival results differ reconciling predictions between two settings...
Significance Our work provides evidence that people who are infected with dengue virus without developing detectable clinical symptoms or prior to the onset of infectious mosquitoes. At a given level viremia, symptom-free were markedly more mosquitoes than clinically symptomatic patients. results fundamentally change current paradigm for epidemiology and control, based on detection virus-infected cases apparent illness.
Zika virus was discovered in Uganda 1947 and is transmitted by Aedes mosquitoes, which also act as vectors for dengue chikungunya viruses throughout much of the tropical world. In 2007, an outbreak Federated States Micronesia sparked public health concern. 2013, began to spread across other parts Oceania 2015, a large Latin America Brazil. Possible associations with microcephaly Guillain-Barré syndrome observed this have raised concerns about continued global virus, prompting its declaration...
Dengue is a disease that has undergone significant expansion over the past hundred years. Understanding what factors limit distribution of transmission can be used to predict current and future limits further dengue expansion. While not only factor, temperature plays an important role in defining these limits. Previous attempts analyse effect on geographic have considered its dynamic intra-annual diurnal change cumulative effects mosquito virus populations. Here we expand existing modelling...