A5051496815- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Global Maternal and Child Health
- Health and Lifestyle Studies
- Health Sciences Research and Education
- Child Nutrition and Water Access
- Healthcare Systems and Reforms
- COVID-19 Pandemic Impacts
- Diagnosis and treatment of tuberculosis
- Gut microbiota and health
- Spatial Cognition and Navigation
- Global Health and Epidemiology
- Augmented Reality Applications
- Chronic Disease Management Strategies
- Respiratory and Cough-Related Research
- Organizational and Employee Performance
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Online and Blended Learning
- Health disparities and outcomes
- COVID-19 Clinical Research Studies
- Public Health and Social Inequalities
Liverpool School of Tropical Medicine
2016-2024
Universidad Peruana Cayetano Heredia
2015-2024
Imperial College London
2014-2024
University of KwaZulu-Natal
2024
Government of West Bengal
2023-2024
Prisma
2016-2023
Pontificia Universidad Católica de Valparaíso
2023
Addis Ababa University
2023
Government Medical College
2023
Wellcome Trust
2014-2022
ALTHOUGH CURABLE, TB frequently leaves the individual with chronic physical and psycho-social impairment, but these consequences have been largely neglected. The 1 st International Post-Tuberculosis Symposium (Stellenbosch, South Africa) was held to discuss priorities gaps in addressing this issue. A barrier progress has varied terminology nomenclature, so Delphi process used achieve consensus on definitions. Lack of sufficient evidence hampered definitive recommendations most domains,...
BACKGROUND: Increasing evidence suggests that post-TB lung disease (PTLD) causes significant morbidity and mortality. The aim of these clinical standards is to provide guidance on the assessment management PTLD implementation pulmonary rehabilitation (PR).METHODS: A panel global experts in field TB care PR was identified; 62 participated a Delphi process. 5-point Likert scale used score initial ideas for after several rounds revision document approved (with 100% agreement).RESULTS: Five were...
MethodsThe study evaluated the impact of a socioeconomic support intervention -described in Box 1 -in 32 contiguous shanty towns Callao, Peru, northern, coastal extension Objective To evaluate on tuberculosis preventive therapy initiation household contacts patients and treatment success patients.Methods A non-blinded, household-randomized, controlled was performed between February 2014 June 2015 Peru.It included being treated for their contacts.Households were randomly assigned to either...
Contacts of tuberculosis index cases are at increased risk developing tuberculosis. Screening, preventive therapy, and surveillance for underused interventions in contacts, particularly adults. We developed a score to predict adult contacts cases.In 2002-06, we recruited aged 15 years or older with pulmonary who lived desert shanty towns Ventanilla, Peru. followed up until February, 2016. used Cox proportional hazards model identify case, contact, household factors from which derive classify...
Poverty drives tuberculosis (TB) rates but the approach to TB control has been disproportionately biomedical. In 2015, World Health Organization's End Strategy explicitly identified need address social determinants of through socio-economic interventions. However, evidence concerning poverty reduction and cost mitigation strategies is limited. The research described in this article, based on 2016 Royal College Physicians Linacre Lecture, aimed knowledge gap. was divided into two phases:...
Cough is the major determinant of tuberculosis transmission. Despite this, there a paucity information regarding characteristics cough frequency throughout day and in response to therapy. Here we evaluate circadian cycle cough, risk factors, impact appropriate treatment on bacillary load. We prospectively evaluated human immunodeficiency virus–negative adults (n = 64) with new diagnosis culture-proven, drug-susceptible pulmonary immediately prior repeatedly until 62. At each time point,...
The epidemiological impact and cost-effectiveness of social protection biomedical interventions for tuberculosis-affected households might be improved by risk stratification. We therefore derived externally validated a household-level score to predict tuberculosis among contacts patients with tuberculosis.
Background. It is difficult to determine whether early tuberculosis treatment effective in reducing the infectiousness of patients' sputum, because culture takes weeks and conventional acid-fast sputum microscopy molecular tests cannot differentiate live from dead tuberculosis.
Background Global tuberculosis policy increasingly emphasises broad impacts and highlights the lack of evidence concerning tuberculosis-related quality life (QOL). Methods Participants were recruited in 32 Peruvian communities between July 13, 2016 February 24, 2018 followed-up until November 8, 2019. Inclusion criteria age ≥15 years for “patients” (n=1545) starting treatment disease health centres; “contacts” (n=3180) who shared a patient's household ≥6 h·week −1 ; randomly selected...
Abstract Objectives Mobile phone interventions have been advocated for tuberculosis care, but little is known about access of target populations to mobile phones. We studied among patients with tuberculosis, focusing on vulnerable and who later had adverse treatment outcomes. Methods In a prospective cohort study in Callao, Peru, we recruited interviewed 2584 between 2007 2013 followed them until 2016 outcomes using national registers. Subsequently, further 622 2017. Data were analysed...
Sputum from patients with tuberculosis contains subpopulations of metabolically active and inactive Mycobacterium unknown implications for infectiousness. We assessed sputum microscopy fluorescein diacetate (FDA, evaluating M. metabolic activity) predicting was quantified in pretreatment pulmonary using FDA microscopy, culture, acid-fast microscopy. These 35 patients' 209 household contacts were followed prevalence surveys disease 6 years. positive a median 119 (interquartile range [IQR],...
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a serious to drugs clinical presentation of rash, fever, lymph node enlargement internal organ involvement. Reports have described the reactivation human herpes virus 6 (HHV-6) other HHVs in association this syndrome. We report 41-year-old woman who developed liver dysfunction, atypical monocytosis 21 days after initiation quadruple therapy for tuberculous cervical lymphadnitis. HHV-7 DNA was detected blood by PCR...
Background Diagnosing tuberculosis in children is challenging because specimens are difficult to obtain and contain low concentrations, especially with HIV-coinfection. Few studies included well-controls so test specificities poorly defined. We studied diagnosis 525 without HIV-infection. Methods Findings ‘Cases’ were suspected pulmonary (n = 209 HIV-negative; n 81 HIV-positive) asymptomatic ‘well-control’ 200 35 HIV-positive). Specimens 2422) gastric aspirates, nasopharyngeal aspirates...
BackgroundCough frequency, and its duration, is a biomarker that can be used in low-resource settings without the need of laboratory culture has been associated with transmission treatment response. Radiologic characteristics increased cough frequency may important understanding transmission. The relationship between cavitary lung disease not studied.MethodsWe analyzed data 41 adults who were HIV negative had culture-confirmed, drug-susceptible pulmonary TB throughout treatment. Cough...