A5007081456- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Occupational and environmental lung diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pleural and Pulmonary Diseases
- Air Quality and Health Impacts
- Influenza Virus Research Studies
- Immunodeficiency and Autoimmune Disorders
- Lung Cancer Diagnosis and Treatment
- Respiratory viral infections research
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Occupational exposure and asthma
- Drug-Induced Hepatotoxicity and Protection
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Viral Infections and Outbreaks Research
- Immune responses and vaccinations
- HIV/AIDS Impact and Responses
- Climate Change and Health Impacts
- COVID-19 epidemiological studies
Hong Kong Tuberculosis, Chest and Heart Diseases Association
2006-2025
Queen Elizabeth Hospital
2024
Chinese University of Hong Kong
2004-2024
Hong Kong Jockey Club
2022
University of Hong Kong
2001-2019
Prince of Wales Hospital
2004-2019
Department of Health
2009-2018
Guangdong General Hospital
2011
Grantham Hospital
2004-2010
Research Center Borstel - Leibniz Lung Center
2010
BACKGROUND: Increasing evidence suggests that post-TB lung disease (PTLD) causes significant morbidity and mortality. The aim of these clinical standards is to provide guidance on the assessment management PTLD implementation pulmonary rehabilitation (PR).METHODS: A panel global experts in field TB care PR was identified; 62 participated a Delphi process. 5-point Likert scale used score initial ideas for after several rounds revision document approved (with 100% agreement).RESULTS: Five were...
Diabetes mellitus is associated with tuberculosis. A cohort of 42,116 clients aged 65 years or more, enrolled at 18 Elderly Health Service centers in Hong Kong 2000, were followed up prospectively through the territory-wide tuberculosis registry for development from 3 months after enrollment to December 31, 2005, by use their identity card numbers as unique identifier. The effects diabetes and diabetic control on risk assessed adjustment sociodemographic other background variables. was a...
The impact of smoking on tuberculosis outcome was evaluated in a territory-wide treatment programme. 16,345 consecutive patients undergoing chemotherapy for active government chest clinics Hong Kong from 2001 to 2003 were followed up prospectively 2 years and subsequently tracked through the notification registry relapse until end 2012. Smoking associated with more extensive lung disease, cavitation positive sputum smear culture at baseline. In both current smokers ex-smokers, smears...
Hong Kong is an intermediate tuberculosis (TB) endemicity city dominated by reactivation diseases. A cross-sectional study on the clinical and epidemiologic data of newly diagnosed TB cases was conducted in such a setting, to examine association between ambient PM2.5 reactivation. After exclusion most likely resulting from recent infection, four distinct population phenotypes were delineated latent class analysis based their risk profiles (N = 2,153): 'Elderly male' (26%), 'Otherwise healthy...
A cohort of 42,655 clients that were first registered with the Elderly Health Service in 2000 followed prospectively through tuberculosis (TB) notification registry until end 2002. total 286 active TB cases (186 culture confirmed) identified. The annual rates 735, 427, and 174 per 100,000 among current smokers, ex-smokers, never-smokers, respectively (p < 0.001). trend risk persisted after control background characteristics using Cox proportional hazards analysis (adjusted hazard ratios...
This nested case–control study aimed at evaluating treatment-related risk factors of relapse tuberculosis under a service program directly observed treatment. Out 12,183 patients with pulmonary who completed treatment within 1 year, 113 relapsed 30 months after commencement therapy. The overall 30-month rate was 0.9% (95% confidence interval [CI] 0.8–1.1%). On matching cases 226 control subjects in conditional logistic model, thrice-weekly increased the comparison daily (odds ratio 3.92, 95%...
Relatively little is known about the hepatotoxicity of pyrazinamide.We compared continuation-phase regimens incorporating pyrazinamide, isoniazid, and/or rifampin with those containing isoniazid and to evaluate pyrazinamide.Cohort nested case-control analyses were conducted on a cohort 3,007 patients active tuberculosis (TB) managed at government chest clinics under TB control program treatment started from January 1 through June 30, 2001. Cases included all probable 12 or more weeks after...
Currently, the standard short-course chemotherapy for tuberculosis comprises a 6-month regimen, with four-drug intensive phase and two-drug continuation phase. Alternative using more costly toxic drugs, often prolonged durations generally >18 months, is required multidrug-resistant extensively drug-resistant tuberculosis. Directly observed treatment, as part of holistic care programme, cost-effective strategy to ensure high treatment success curtail development drug resistance in New...