A5101516330- Health disparities and outcomes
- Mosquito-borne diseases and control
- Asthma and respiratory diseases
- Viral Infections and Vectors
- Gene expression and cancer classification
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Statistical Methods and Inference
- Urban, Neighborhood, and Segregation Studies
- Statistical Methods and Bayesian Inference
- MRI in cancer diagnosis
- Viral Infections and Outbreaks Research
- Homelessness and Social Issues
- Alcohol Consumption and Health Effects
- Cancer Risks and Factors
- Advanced Proteomics Techniques and Applications
- Receptor Mechanisms and Signaling
- Workplace Health and Well-being
- Antifungal resistance and susceptibility
- Dengue and Mosquito Control Research
- vaccines and immunoinformatics approaches
- Acupuncture Treatment Research Studies
- Autonomous Vehicle Technology and Safety
- Alcoholism and Thiamine Deficiency
- Fungal Infections and Studies
United States Food and Drug Administration
2020
The University of Texas Medical Branch at Galveston
2007-2017
General Department of Preventive Medicine
2007-2014
Rowan University
2012
University of North Carolina at Chapel Hill
2012
Galveston College
2010
The University of Texas at San Antonio
2009
John Sealy Hospital
2008
To examine whether neighborhood-level socioeconomic status is an independent risk factor for health behaviors.Data from the Third National Health and Nutrition Examination Survey were linked with census tracts 1990 US Census. Outcome variables included biomarkers smoking high dietary fat intake, self-reported excessive alcohol consumption physical inactivity.Multivariate logistic regression showed association between levels of neighborhood deprivation increased odds behaviors...
Dengue virus infections are a major cause of morbidity in tropical countries. Early detection dengue hemorrhagic fever (DHF) may help identify individuals that would benefit from intensive therapy. Predictive modeling was performed using 11 laboratory values 51 (38 DF and 13 DHF) obtained on initial presentation logistic regression. We produced robust model with an area under the curve 0.9615 retained IL-10 levels, platelets, lymphocytes as predictive features. A classification regression...
Abstract An important problem in realizing personalized medicine is the development of methods for identifying disease subtypes using quantitative proteomics. Recently we found that bronchoalveolar lavage (BAL) cytokine patterns contain information about dynamic lung responsiveness. In this study, examined physiological data from 1,048 subjects enrolled US Severe Asthma Research Program (SARP) to identify four largely separable, intermediate phenotypes. Upper extremes study population were...
Background: Hyper-methylation of CpG dinucleotides in the promoter region inhibitor cyclin-dependent kinase 4A (INK4A) has been reported 60%–80% hepatocellular carcinoma (HCC). As INK4A hypermethylation event occurs early HCC progression, quantification methylation blood sample may represent a useful biomarker for non-invasive diagnosis and prediction response to therapy.
Chronic hepatic disease damages the liver, and resulting wound-healing process leads to liver fibrosis subsequent development of cirrhosis. The leading cause cirrhosis is infection with hepatitis C virus (HCV), patients HCV-induced cirrhosis, 2% 5% develop hepatocellular carcinoma (HCC), a survival rate 7%. HCC one causes cancer-related death worldwide, poor largely due late-stage diagnosis, which makes successful intervention difficult, if not impossible. lack sensitive specific diagnostic...
In a previous study, we showed that electroacupuncture (EA) applied to the SI-6 point on contralateral forelimb produces long-lasting and powerful analgesia in pain caused by ankle sprain rat model. To investigate underlying mechanism of EA analgesia, present study tested effects various antagonists known endogenous analgesic systems this Ankle was induced anesthetized rats overextending their right with repeated forceful plantar flexion inversion foot. When developed behaviors (a reduction...
Asthmatic patients are currently classified as either severe or non-severe based primarily on their response to glucocorticoids. However, because this classification is a post-hoc assessment of treatment response, it does not inform the rational staging disease therapy. Recent studies in other diseases suggest that which includes molecular information could lead more accurate diagnoses and prediction response. We therefore measured cytokine values bronchoalveolar lavage (BAL) samples lower...
Abstract Secondary dengue viral infection can produce capillary leakage associated with increased mortality known as hemorrhagic fever (DHF). Because the of DHF be reduced by early detection and intensive support, improved methods for its are needed. We applied multidimensional protein profiling to predict outcomes in a prospective surveillance study South America. Plasma samples taken from initial clinical presentation acute were subjected proteomics analyses using ELISA recently developed...
We explore the association between a neighbourhood's ethnic composition and foods nutrients consumed by Mexican-Americans.
Women with mostly mammographically dense fibroglandular tissue (breast density, BD) have a four- to six-fold increased risk for breast cancer compared women little BD. BD is most frequently estimated from two-dimensional (2D) views of mammograms by histogram segmentation approach (HSM) and more recently mathematical algorithm consisting mammographic imaging parameters (MATH). Two non-invasive clinical magnetic resonance (MRI) protocols: 3D gradient-echo (3DGRE) short tau inversion recovery...
The aim of this study was to determine the prevalence bile cast nephropathy (BCN) in autopsied cirrhotic patients and correlate BCN with clinical laboratory data direct attention underrecognized renal complication liver failure.We assessed 114 autopsy cases cirrhosis for presence intratubular casts using Hall stain bile. Presence correlated etiology cirrhosis, data, histologic findings.Bile were identified 55% cases. most common hepatitis C virus (HCV) infection (52%), serum creatinine ( P =...
Invasive pulmonary aspergillosis (IPA) is an opportunistic fungal infection in patients undergoing chemotherapy for hematological malignancy, hematopoietic stem cell transplant, or other forms of immunosuppression. In this group, Aspergillus infections account the majority deaths due to mold pathogens. Although early detection associated with improved outcomes, current diagnostic regimens lack sensitivity and specificity. Patients chemotherapy, transplantation lung were enrolled a multi-site...
Abstract Prediction of mortality in severely burned patients remains unreliable. Although clinical covariates and plasma protein abundance have been used with varying degrees success, the triad burn size, inhalation injury, age most reliable predictor. We investigated effect combining proteomics variables these three on prediction children. Serum samples were collected from 330 children (burns covering >25% total body surface area) between admission time first operation for chemistry...
The choice of selection methods to identify important variables for binary classification modeling is critical produce stable models that are interpretable, generate accurate predictions and have minimum bias. This work motivated by data on clinical laboratory features severe dengue infections (dengue hemorrhagic fever, DHF) obtained from 51 individuals enrolled in a prospective observational study acute human infections. We carry out comprehensive performance comparison using several DHF...
BackgroundMexican American men living in the United States who are more acculturated exhibit higher rates of cancer compared to those less acculturated. This study explored association between acculturation and serum levels nutrients thought be involved with prevention among Mexican men. MethodsOur sample included 2,479 from Third National Health Nutrition Examination Survey (1988-1994). Outcomes were micronutrients. Acculturation was assessed by a combined measure including country origin,...