A5023323789- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Metabolomics and Mass Spectrometry Studies
- Drug Transport and Resistance Mechanisms
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Eicosanoids and Hypertension Pharmacology
- Eosinophilic Disorders and Syndromes
- Peroxisome Proliferator-Activated Receptors
- Drug-Induced Hepatotoxicity and Protection
- Endoplasmic Reticulum Stress and Disease
- Pesticide Residue Analysis and Safety
- Pharmacogenetics and Drug Metabolism
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Pesticide Exposure and Toxicity
- Metabolism and Genetic Disorders
- Neurogenesis and neuroplasticity mechanisms
- Diet and metabolism studies
- Lipid metabolism and biosynthesis
- Effects and risks of endocrine disrupting chemicals
- Nerve injury and regeneration
The University of Texas Medical Branch at Galveston
2015-2024
Galveston College
2011
Indian Institute of Toxicology Research
1984-1990
National Institute for Interdisciplinary Science and Technology
1981-1983
<h3>Objective</h3> Non-oxidative metabolism of ethanol (NOME) produces fatty acid ethyl esters (FAEEs) via carboxylester lipase (CEL) and other enzyme action implicated in mitochondrial injury acute pancreatitis (AP). This study investigated the relative importance oxidative non-oxidative pathways dysfunction, pancreatic damage development alcoholic AP, whether deleterious effects NOME are preventable. <h3>Design</h3> Intracellular calcium ([Ca<sup>2+</sup>]<sub>C</sub>), NAD(P)H, membrane...
Alcohol use disorder is a major risk factor for alcohol-associated liver disease (ALD), characterized by reduced hepatic alcohol dehydrogenase (ADH) activity, increased body burden of and its nonoxidative metabolism to fatty acid ethyl esters (FAEEs). However, the mechanism(s) underlying ALD remain unclear. This study investigated metabolic basis in chronic ethanol (EtOH) fed ADH1-deficient (ADH − ) deer mice administered with single dose binge EtOH with/without FAEEs. Hepatic ADH normal +...
Background: Hepatic steatosis (fatty liver), an early and reversible stage of alcoholic liver disease, is characterized by triglyceride deposition in hepatocytes, which can advance to steatohepatitis, fibrosis, cirrhosis, ultimately hepatocellular carcinoma. In the present work, we studied altered plasma hepatic lipid metabolome (lipidome) understand mechanisms pattern early‐stage alcohol‐induced‐fatty liver. Methods: Male Fischer 344 rats were fed 5% alcohol a Lieber‐DeCarli diet. Control...
Aims: To understand the mechanism(s) of alcoholic pancreatitis and role fatty acid ethyl esters (FAEEs, non-oxidative metabolites ethanol) in ethanol-induced pancreatic injury. Methods: A time- concentration-dependent synthesis FAEEs cytotoxicity ethanol its predominant were studied rat tumour (AR42J) cells cultures. Role was investigated by measuring FAEEs, injury markers apoptosis incubated simultaneously with FAEE synthase inhibitor, 3-benzyl-6-chloro-2-pyrone. The pre-incubated caspase-3...
A total of 244 samples cereals (wheat flour, rice, and maize), pulses (arhar, moong, gram, lentil, black gram), spices (turmeric, chili, coriander, pepper), vegetables (potato, onion, spinach, cabbage, brinjal, tomato), fruits (mango, guava, apple, grape), milk, butter, Deshi ghee, edible oils (vegetable, mustard, groundnut, sesame) collected from different cities Northern Province (Utter Pradesh) were analyzed by gas liquid chromatography for the presence organochlorine pesticide residues....
Abstract Macrophages, in general, are critical effectors of body's immune system. Chemical inhibition phagocytic activity such macrophages as Kupffer cells has been extensively studied. We have earlier shown that methyl palmitate (MP) inhibits the activation cells. To evaluate potential MP to inhibit other macrophages, we treated rat peritoneal with varying concentrations MP. Its treatment led a dose‐dependent activity, which was found be 34%, 47%, and 66% at 0.25, 0.50, 1.0 mM MP,...