J. A. Armstrong
A5059845458- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pancreatitis Pathology and Treatment
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Animal Virus Infections Studies
- Herpesvirus Infections and Treatments
- Protein Tyrosine Phosphatases
- Tuberculosis Research and Epidemiology
- Biochemical and Molecular Research
- Insect Resistance and Genetics
- Palliative Care and End-of-Life Issues
- Patient Dignity and Privacy
- Mosquito-borne diseases and control
- Toxoplasma gondii Research Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Insect Pheromone Research and Control
- Nosocomial Infections in ICU
- COVID-19 and healthcare impacts
- SARS-CoV-2 detection and testing
- Insects and Parasite Interactions
- Entomopathogenic Microorganisms in Pest Control
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
University of Liverpool
2013-2024
Sheffield Teaching Hospitals NHS Foundation Trust
2023
International Severe Acute Respiratory and Emerging Infection Consortium
2023
St Mary's Hospital
2023
The Queen's Medical Research Institute
2022
Centre for Inflammation Research
2022
University of Edinburgh
2022
Royal Liverpool University Hospital
2014-2020
Nottingham Biomedical Research Centre
2020
University of Nottingham
2020
Studies of patients admitted to hospital with COVID-19 have found varying mortality outcomes associated underlying respiratory conditions and inhaled corticosteroid use. Using data from a national, multicentre, prospective cohort, we aimed characterise people disease, assess the level care received, measure in-hospital mortality, examine effect use.We analysed International Severe Acute Respiratory emerging Infection Consortium (ISARIC) WHO Clinical Characterisation Protocol UK (CCP-UK)...
<h3>Objective</h3> Non-oxidative metabolism of ethanol (NOME) produces fatty acid ethyl esters (FAEEs) via carboxylester lipase (CEL) and other enzyme action implicated in mitochondrial injury acute pancreatitis (AP). This study investigated the relative importance oxidative non-oxidative pathways dysfunction, pancreatic damage development alcoholic AP, whether deleterious effects NOME are preventable. <h3>Design</h3> Intracellular calcium ([Ca<sup>2+</sup>]<sub>C</sub>), NAD(P)H, membrane...
Acute kidney injury (AKI) is common in coronavirus disease 2019 (COVID-19). This study investigated adults hospitalized with COVID-19 and hypothesized that risk factors for AKI would include comorbidities non-White race.
Mitochondrial dysfunction lies at the core of acute pancreatitis (AP). Diverse AP stimuli induce Ca2+-dependent formation mitochondrial permeability transition pore (MPTP), a solute channel modulated by cyclophilin D (CypD), which causes ATP depletion and necrosis. Oxidative stress reportedly triggers MPTP is elevated in clinical AP, but how reactive oxygen species influence cell death unclear. Here, we assessed potential involvement oxidant-induced effects on pancreatic acinar bioenergetics...
To determine any change in referral patterns and outcomes children (0-18) referred for child protection medical examination (CPME) during the COVID-19 pandemic compared with previous years.Retrospective observational study, analysing routinely collected clinical data from CPME reports a rapid response to lockdown.Birmingham Community Healthcare NHS Trust, which provides all routine Birmingham, England, population 1.1 million including 288 000 children.Children aged under 18 years attending...
Bacterial pathogens have developed sophisticated mechanisms of evading the immune system to survive in infected host cells. Central pathogenesis Mycobacterium tuberculosis is arrest phagosome maturation, partly through interference with PtdIns signalling. The protein phosphatase MptpB an essential secreted virulence factor M. tuberculosis. A combination bioinformatics analysis, enzyme kinetics and substrate-specificity characterization revealed that exhibits both dual-specificity activity...
Journal Article Breast-Feeding during Primary Maternal Human Immunodeficiency Virus Infection and Risk of Transmission from Mother to Infant Get access P. Palasanthiran, Palasanthiran Search for other works by this author on: Oxford Academic PubMed Google Scholar J. B. Ziegler, Ziegler Reprints or correspondence: Dr. Department Immunology/Allergy, Prince Wales Children's Hospital, Randwick, NSW, Australia 2031. G. Stewart, Stewart M. Stuckey, Stuckey A. Armstrong, Armstrong D. Cooper, Cooper...
Abstract Background Predicting bed occupancy for hospitalised patients with COVID-19 requires understanding of length stay (LoS) in particular types. LoS can vary depending on the patient’s “bed pathway” - sequence transfers individual between types during a hospital stay. In this study, we characterise these pathways, and their impact predicted occupancy. Methods We obtained data from University College Hospital (UCH) ISARIC4C Clinical Information Network (CO-CIN) who required care general...
Although oxidative stress has been strongly implicated in the development of acute pancreatitis (AP), antioxidant therapy patients so far discouraging. The aim this study was to assess potential protective effects a mitochondria-targeted antioxidant, MitoQ, experimental AP using vitro and vivo approaches. MitoQ blocked H 2 O -induced intracellular ROS responses murine pancreatic acinar cells, an action not shared by control analogue dTPP. did reduce mitochondrial depolarisation induced...
Glaucoma is a progressive optic neuropathy characterized by the neurodegeneration of retinal ganglion cells (RGCs) resulting in irreversible visual impairment and eventual blindness. RGCs are extremely susceptible to mitochondrial compromise due their marked bioenergetic requirements morphology. There increasing interest therapies targeting health as method preventing loss managing glaucoma. The profile Tenon's ocular fibroblasts from glaucoma patients controls was investigated using...
The aim of this study was to develop a fluorescent reactive oxygen species (ROS) probe, which is preferentially localized in cellular membranes and displays strong change fluorescence upon oxidation. We also aimed test the performance probe for detecting pathophysiologically relevant ROS responses isolated cells.We introduced novel lipophilic dihydrorhodamine B octadecyl ester (H2RB-C18). then applied new characterize changes triggered by inducers acute pancreatitis pancreatic acinar cells....
Abstract Background SARS-CoV-2 is frequently shed in the stool of patients hospitalised with COVID-19. The extent faecal shedding among individuals community, and its potential to contribute spread disease, unknown. Methods In this prospective, observational cohort study households Liverpool, UK, participants underwent weekly nasal/throat swabbing detect virus, over a 12-week period from enrolment starting July 2020. Participants that tested positive for were asked provide sample three 14...
Acute pancreatitis is a frequent disease that lacks specific drug treatment. Unravelling the molecular mechanisms of acute essential for development new therapeutics. Several inducers trigger sustained Ca2+ increases in cytosol and mitochondria pancreatic acinar cells. The mitochondrial calcium uniporter (MCU) mediates uptake regulates bioenergetics plays an important role cell survival, damage death. Aberrant signaling cells have been implicated initiation pancreatitis. primary aim this...
Objective To examine public opinion regarding certain elements of consent: disclosure, advance directives, substitute decisions, emergency treatment, and advocacy. Design Cross‐sectional random‐digit‐dialing telephonic survey. Setting General public. Participants One thousand randomly‐selected adults living in Ontario. Interventions None. Main Outcome Measures Self‐reported attitudes behaviors. Results Of 5,708 telephone numbers drawn, 641 were non‐valid or non‐residential, 1,283 not...
Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess gallstones, which lacks specific therapy. The role of Receptor-Interacting Protein Kinase 1 (RIPK1), key component programmed necrosis (Necroptosis), unclear in AP. We assessed the effects RIPK1 inhibitor Necrostatin-1 (Nec-1) modification (RIPK1K45A: kinase dead) bile acid (TLCS-AP), alcoholic (FAEE-AP) caerulein hyperstimulation (CER-AP) mouse models. Involvement collateral Nec-1 target...
Mitochondrial dysfunction is a core feature of acute pancreatitis, severe disease in which oxidative stress elevated. targeting antioxidants potential therapeutic strategy for this and other diseases, although thus far mixed results have been reported. We investigated the effects mitochondrial with antioxidant MitoQ on pancreatic acinar cell bioenergetics, adenosine triphosphate (ATP) production fate, comparison non-antioxidant control decyltriphenylphosphonium bromide (DecylTPP) general...
(1958). Insecticide Resistance in Anopheles Gambiae Giles Western Sokoto, Northern Nigeria. Annals of Tropical Medicine & Parasitology: Vol. 52, No. 3, pp. 247-256.
Abstract Objectives To determine any change in referral patterns and outcomes children (0-18) referred for child protection medical examination (CPME) during the covid-19 pandemic compared to previous years. Design Retrospective observational study, analysing routinely collected clinical data from CPME reports a rapid response lockdown. Setting Birmingham Community Healthcare NHS Trust, which provides all routine Birmingham, England, population 1.1 million including 288,000 children....
F1F0-ATP synthase inhibitory factor 1 (IF1) inhibits the reverse mode of synthase, and therefore protects cellular ATP content at expense accelerated loss mitochondrial membrane potential (ΔΨm). There is considerable variability in IF1 expression its influence on bioenergetics between different cell types. High levels a number cancers have been linked to increased glycolysis, resistance death, migration proliferation. However, neither nor role normal pancreas or pancreatic cancer has...