A5090825910- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- Angiogenesis and VEGF in Cancer
- Ocular Surface and Contact Lens
- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Mitochondrial Function and Pathology
- Ocular Infections and Treatments
- Retinal and Macular Surgery
- Anesthesia and Pain Management
- Shoulder Injury and Treatment
- Retinal and Optic Conditions
- Ophthalmology and Eye Disorders
- Herpesvirus Infections and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Nasolacrimal Duct Obstruction Treatments
- Surgical Simulation and Training
- Neurological Disorders and Treatments
- Tendon Structure and Treatment
- Viral-associated cancers and disorders
- Cardiovascular Syncope and Autonomic Disorders
- Ophthalmology and Visual Impairment Studies
- Protease and Inhibitor Mechanisms
Little Rock School District
2025
University of Liverpool
2014-2024
Royal Liverpool University Hospital
2014-2024
Royal Liverpool and Broadgreen University Hospital NHS Trust
2006-2013
New Mexico Military Institute
2001
Aims To compare the biomechanically corrected intraocular pressure (IOP) estimate (bIOP) provided by Corvis-ST with Goldmann applanation tonometry (GAT-IOP) in patients high-tension and normal-tension primary open-angle glaucoma (POAG; HTG NTG), ocular hypertension (OHT) controls. Moreover, we compared dynamic corneal response parameters (DCRs) of POAG, OHT controls, evaluated correlation between global visual field mean deviation pattern SD (MD PSD) DCRs POAG group. Methods 156 eyes were...
To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10 15 µg bimatoprost implant in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). This randomized, 20-month, multicenter, masked, parallel-group, phase 3 trial enrolled 528 OAG OHT an open iridocorneal angle inferiorly study eye. Study eyes were administered on day 1, week 16, 32, twice-daily topical timolol maleate 0.5%. Primary endpoints IOP change from baseline through 12. Safety measures...
Glaucoma is a sight threatening neurodegenerative condition of the optic nerve head associated with ageing and marked by loss retinal ganglion cells. Mitochondrial dysfunction plays crucial role in pathogenesis neurodegeneration most prevalent type glaucoma: primary open angle glaucoma (POAG). All previous mitochondrial genome sequencing studies POAG analyzed DNA (mtDNA) isolated from peripheral blood leukocytes have not evaluated cells derived ocular tissue, which better represent...
ABSTRACT Kaposi's sarcoma‐associated herpesvirus (KSHV) is the etiologic agent of several human cancers, including primary effusion lymphoma (PEL), usually seen in immunocompromised patients while lack effective therapeutic options. Interleukin‐1 (IL‐1) family a major mediator for inflammatory responses and has functional role both innate adaptive immunity. We previously showed high activation multiple IL‐1 signaling molecules during KSHV latent lytic stages, as well clinical samples from...
PurposeTo investigate the use of anterior segment-optical coherence tomography (AS-OCT) to visualise aqueous outflow pathway and patency scleral flap in glaucoma filtration surgery blebs.DesignCross-sectional studySubjects205 filtering blebs 112 patients with who had undergone trabeculectomy (Trab, n = 97) or deep sclerectomy (DS, 108) with/without mitomycin-C (MMC).MethodsSwept source AS-OCT raster slices were used image Trab DS sagittal coronal planes using a standardised protocol. Bleb...
A bstract Purpose: To document the outcome of viscocanalostomy (VC) alone or combined with phacoemulsification (phaco‐VC) in eyes pseudoexfoliation glaucoma (PEXG) and primary open angle (POAG). Methods: prospective, comparative study 314 undergoing VC two centres over 6 years was conducted. Main measures were: (i) intraocular pressure (IOP) control (complete success IOP ≤ 18 mmHg without medication failure > mmHg); (ii) requirement for Nd:YAG laser goniopuncture (YAG‐GP) if 21 mmHg....
Glaucoma is a progressive optic neuropathy characterized by the neurodegeneration of retinal ganglion cells (RGCs) resulting in irreversible visual impairment and eventual blindness. RGCs are extremely susceptible to mitochondrial compromise due their marked bioenergetic requirements morphology. There increasing interest therapies targeting health as method preventing loss managing glaucoma. The profile Tenon's ocular fibroblasts from glaucoma patients controls was investigated using...
The aim of this study was to assess the role mycophenolate mofetil (MMF) in refractory inflammatory eye disease.Retrospective, noncomparative, interventional case series all patients commenced on MMF between 1999 and 2005 for disease at St Paul's Eye Unit (Liverpool, UK). Main outcome measures noted were control inflammation, steroid-sparing effect, adverse effects therapy.Ten (10) (2 with sarcoid, 2 intermediate uveitis, 1 Vogt-Koyanagi Harada (VKH) syndrome, ankylosing spondylitis,...
This paper describes a technique for using swept-source anterior segment optical coherence tomography (AS-OCT) to visualize internal bleb microstructure and objectively quantify dimensions of the scleral flap trabeculo-Descemet window (TDW) in non-penetrating glaucoma filtration surgery (GFS). was cross-sectional study 107 filtering blebs 67 patients who had undergone deep sclerectomy at least 12 months prior. The mean post-operative follow-up duration 6.5 years +/- 4.1 [standard deviation...
A bstract Purpose: To investigate the long‐term efficacy and safety of non‐penetrating glaucoma surgery (NPGS) augmented with mitomycin C (MMC) or 5‐fluorouracil (5FU) in eyes at high risk failure filtration surgery. Methods: Prospective study all eyes, undergoing NPGS 0.04% MMC (1 to 2 min topical 0.04 mL subconjunctival injection into superior fornix) 5FU (25 mg/mL topically for 5 min). Complete success was an intraocular pressure (IOP) ≤ 21 mmHg on no medication qualified IOP medication....
Purpose . To report a case of pigmented corneal iron lines following use tinted soft contact lenses (CL). Methods A retrospective report. Results 16-year-old girl was referred with suspected CL-related keratopathy OU, having recently switched to monthly disposable CLs (8.4/14.0 −3.00 OD, −3.25 OS Aquamarine SofLens Natural Colours, Bausch and Lomb, New York, USA). Both corneas exhibited symmetric superficial lines, which gradually disappeared discontinuation CL wear. Conclusions Pigmented...
To determine the medium-term outcomes for patients with advanced glaucoma undergoing viscocanalostomy. All (mean deviation (MD) − 12.00 dB or above) and poor visual acuity secondary to which precluded formal field assessment viscocanalostomy (VC) phaco-viscocanalostomy between 2010 2014 under care of a single surgical team were included. Intraocular pressure (IOP), (VA) assessed from data prospectively collected into outcome database. Success was defined at two IOP cut-off points: ≤ 21 16...
Objective assessment of surgical and technical skills (OSATS) workplace-based tool is now mandatory during ophthalmology speciality training in the United Kingdom. The opinions those undergoing this have not been formally sought. This study evaluated views trainees on OSATS as applied to cataract surgery. A questionnaire was circulated 34 Mersey deanery. total 28 responses were received. most positive aspects process identified feedback, learning opportunity for reflective practice. negative...
In this paper, we investigate the effect of sedation using low-dose propofol on patient reported outcome measures (PROMS) in patients undergoing cataract surgery. This is a randomised, single-blinded observational prospective study. Patients elective surgery peribulbar anaesthesia over consecutive lists were selected for trial. randomised to receive either no or (20 30 mg followed by 10 increments until developed slurred speech alone) prior administration local anaesthesia. Pain,...
Elevated intraocular pressure (IOP) is a major risk factor for the development of primary open-angle glaucoma (POAG). This from an increased aqueous humour (AH) outflow resistance through trabecular meshwork (TM). The pathogenic mechanisms leading to increase in TM are poorly understood but thought be dysregulation extracellular matrix (ECM) environment. ECM modification and turnover crucial regulating outflow. influenced by complex interplay growth factors such as transforming (TGFβ) family...
In trabecular meshwork (TM) cells, actin geodesic arrangements were measured and then subjected to computational modeling appreciate the response of different dome shapes mechanical force.Polygonal (PAAs) cross-linked networks (CLANs) induced imaged by Alexa Flour(®) 488 Phalloidin in bovine TM human cells. Masked images examined for size, circularity, spoke hub dimensions using ImageJ. Finite element was used create idealized structures "realistic" PAA CLAN models. The models loads...