A5032164477- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Corneal surgery and disorders
- Neurological Disorders and Treatments
- Ocular Surface and Contact Lens
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Connexins and lens biology
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- S100 Proteins and Annexins
- Ocular Infections and Treatments
- Ophthalmology and Eye Disorders
- 14-3-3 protein interactions
- Endoplasmic Reticulum Stress and Disease
- Immune Response and Inflammation
- Migraine and Headache Studies
- Retinopathy of Prematurity Studies
- Nuclear Receptors and Signaling
- melanin and skin pigmentation
- Cardiovascular Syncope and Autonomic Disorders
National Health and Medical Research Council
2023-2025
Cooperative Trials Group for Neuro-Oncology
2025
The University of Sydney
2023-2025
Duke-NUS Medical School
2021-2025
Vision Cooperative Research Centre
2025
Singapore Eye Research Institute
2021-2024
Singapore National Eye Center
2021-2023
University Medical Center of the Johannes Gutenberg University Mainz
2012-2022
Johannes Gutenberg University Mainz
2013-2022
Centro de Investigaciones Biológicas Margarita Salas
2020
Purpose To evaluate the safety and tolerability of intravitreal ISTH0036, an antisense oligonucleotide selectively targeting transforming growth factor beta 2 (TGF-β2), in patients with primary open angle glaucoma (POAG) undergoing trabeculectomy (TE; filtration surgery). Methods In this prospective phase I trial scheduled for TE mitomycin C (MMC) received a single injection ISTH0036 at end surgery escalating total doses 6.75 μg, 22.5 67.5 μg or 225 resulting calculated intraocular...
To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10 15 µg bimatoprost implant in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). This randomized, 20-month, multicenter, masked, parallel-group, phase 3 trial enrolled 528 OAG OHT an open iridocorneal angle inferiorly study eye. Study eyes were administered on day 1, week 16, 32, twice-daily topical timolol maleate 0.5%. Primary endpoints IOP change from baseline through 12. Safety measures...
ABSTRACT Age and elevated intraocular pressure (IOP) are the two major risk factors for developing glaucoma, a leading cause of blindness worldwide that is characterized by loss retinal ganglion cells (RGCs). Although vision irreversible over long term, accumulating evidence points to short‐term improvement in glaucoma patients response certain interventions, suggesting RGCs have capacity recover function. In present study, we sought investigate mechanisms underlying recovery RGC function...
Glaucoma is a common age-related disease leading to progressive retinal ganglion cell (RGC) death, visual field defects and vision loss the second cause of blindness in elderly worldwide. Mitochondrial dysfunction impaired autophagy have been linked glaucoma induction shows neuroprotective effects animal models. We shown that decreases with aging retina can be for RGCs, but it currently unknown how deficiency impact RGCs susceptibility survival. Using optic nerve crush model young...
Mitochondrial damage plays a prominent role in glaucoma. The only way cells can degrade whole mitochondria is via autophagy, process called mitophagy. Thus, studying mitophagy the context of glaucoma essential to understand disease. Up date limited tools are available for analyzing vivo. We have taken advantage mito-QC reporter, recently generated mouse model that allows an accurate assessment fill this gap. used primary RGCs and retinal explants derived from mice quantify activation vitro...
Purpose: The aim of this study was to explore the roles crystallins in context aging glaucoma and potential mechanisms neuroprotection an experimental animal model glaucoma. Methods: Intraocular pressure (IOP) significantly elevated for 8 weeks animals at different ages (10 days, 12 weeks, 44 weeks) by episcleral vein cauterization. Retinal ganglion cells (RGCs) were quantified anti-Brn3a immunohistochemical staining (IHC). Proteomics using ESI-LTQ Orbitrap XL-MS used analyze presence...
Glaucoma, a neurodegenerative disease, is characterized by progressive loss of retinal ganglion cells (rgc). Up- and down-regulated autoantibody immunoreactivities in glaucoma patients have been demonstrated. Previous studies showed protective effects antibodies [gamma (γ)-synuclein glial fibrillary acidic protein [GFAP]) on neuroretinal cells. The aim this study was to test these antibody rgc an organ culture model get better understanding cell-cell interactions the retina context effect....
Purpose Previous studies show significantly specifically changed autoantibody reactions against retinal antigens in the serum of glaucoma and ocular hypertension (OHT) patients comparison to healthy people. As pathogenesis still is unknown aim this study was analyze if antibodies interact with neuroretinal cells. Methods R28 cells were incubated suffering from primary open angle (POAG), normal tension (NTG) or OHT, POAG after antibody removal people for 48 h under a an elevated pressure...
Previous studies demonstrate changes of autoantibody concentrations against retinal and optic nerve head antigens in the serum glaucoma patients comparison to healthy persons. These antibodies belong natural autoimmunity. showed up regulated, but also significantly down-regulated levels. have ability influence protein profiles neuroretinal cells possibly hold neuroprotective potential, as we been able before. Aim this study was analyse antibody effect on more detail determine impact found...
Autoantibody profiling has gained increasing interest in the research field of glaucoma promising detection highly specific and sensitive marker candidates for future diagnostic purposes. Recent studies demonstrated that immune responses are characterized by expression congruent or similar complementarity determining regions (CDR) different individuals could be used as molecular targets biomarker discovery. Main objective this study was to characterize glaucoma-specific peptides from...
The pathogenesis of glaucoma, a common neurodegenerative disease, involves an immunologic component. Changes in the natural autoantibody profile glaucoma patients were detected, showing not only up-regulated but also down-regulated immunoreactivities. In recent studies we able to demonstrate that antibody changes have large influence on protein profiles neuroretinal cells. Furthermore could neuroprotective potential one antibodies (γ-synuclein antibody). Anti-GFAP is another found patients....
The family of synuclein proteins (α, β and γ) are related to neurodegenerative disease e.g. Parkinson Morbus Alzheimer. Additionally, a connection between γ-synuclein glaucoma, characterized by progressive loss retinal ganglion cells, which finally leads blindness, exists. reason for the development glaucoma is still unknown. Recent studies evaluating participation immunological components, demonstrate complex changed antibody reactivities in patients comparison healthy people, showing not...
To examine vision-related quality of life in patients with diabetic macular edema (DME) treated intravitreal aflibercept (EYLEA, Regeneron Pharmaceuticals, Inc, Tarrytown, NY). AQUA was a multicenter, open-label, single-arm, phase 4 study. Adults 18 years age or older type 1 2 diabetes mellitus and DME. Patients received mg every 8 weeks for 52 weeks, after 5 initial doses weeks. The primary outcome the change 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) total...
Many studies analyzing neurodegenerative diseases demonstrate altered frequencies of regulatory T cells (Tregs). Till date, there is hardly any information concerning Tregs in glaucoma. To gather first results Treg levels glaucoma patients, we aimed to investigate whether the number CD4(+)CD25(+)T vary patients suffering from primary open-angle (POAG) and healthy controls.Heparinized blood samples were collected 16 individuals POAG patients. The groups age gender matched. A density gradient...