A5086662698- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Cerebral Venous Sinus Thrombosis
- Systemic Lupus Erythematosus Research
- Ophthalmology and Visual Impairment Studies
- Optical Coherence Tomography Applications
- Atherosclerosis and Cardiovascular Diseases
- Dermatological and Skeletal Disorders
- Cerebrovascular and Carotid Artery Diseases
- Drug-Induced Ocular Toxicity
- Ocular Oncology and Treatments
- Antioxidant Activity and Oxidative Stress
- Intraocular Surgery and Lenses
- Neurological Complications and Syndromes
- Acute Ischemic Stroke Management
- melanin and skin pigmentation
- Hemoglobinopathies and Related Disorders
- Retinoids in leukemia and cellular processes
- Ocular Infections and Treatments
- Peripheral Artery Disease Management
Hôpital Intercommunal de Créteil
2016-2025
Université Paris-Est Créteil
2015-2024
Paris-Est Sup
2013-2024
Université Paris Cité
2007-2023
Duke University
2023
Cleveland Eye Clinic
2023
Cleveland Clinic
2023
Sierra Eye Associates
2023
Wolfe Eye Clinic
2023
Hospital Quirón Teknon
2023
Advanced age-related macular degeneration (AMD) is the leading cause of late onset blindness. We present results a genome-wide association study 979 advanced AMD cases and 1,709 controls using Affymetrix 6.0 platform with replication in seven additional cohorts (totaling 5,789 unrelated 4,234 controls). also comprehensive analysis copy-number variations polymorphisms for AMD. Our discovery data implicated between variant hepatic lipase gene (LIPC) high-density lipoprotein cholesterol (HDL)...
To establish a normative database for vascular density (VD) and foveal avascular zone (FAZ) at the superficial (SCP) deep capillary plexus (DCP) in healthy subjects with optical coherence tomography (OCT) angiography.The study was retrospective chart review of patients who had undergone OCT angiography imaging. A 3- × 3-mm area, centered on fovea, scanned all eyes. The automated segmentation allowed separate analysis SCP, DCP, comprehensive C-scan including both layers. On obtained images,...
To compare optical coherence tomography angiography (OCTA) with traditional multimodal imaging in patients exudative age-related macular degeneration terms of guiding the treatment decision.Prospective case series 80 eyes 73 consecutive (39 women, mean age: 79.4 ± 5.3 years) diagnosed different types choroidal neovascularization (CNV) (58 Type I, 2 II, 6 mixed I and 3 retinal angiomatous proliferation, 11 degeneration-related polyps). The data obtained from imaging, based on fluorescein...
To compare the anatomic and functional efficacy safety of half-dose photodynamic therapy (PDT) versus high-density subthreshold micropulse laser (HSML) treatment in patients with chronic central serous chorioretinopathy (cCSC).
To investigate the changes in macular choroidal thickness eyes with various stages of diabetic retinopathy, using enhanced depth imaging optical coherence tomography (EDI OCT).Sixty-three consecutive patients--who presented without retinopathy (NDR); (nonproliferative [NPDR]) and no clinically significant edema (CSME-); or NDPR (CSME+)--underwent EDI OCT. Twenty-one age- sex-matched healthy subjects (21 eyes) also underwent OCT.A total 63 patients (26 female [41.2%]; mean age 65 ± 9 years,...
PurposeTo compare the efficacy and safety of brolucizumab with aflibercept in patients diabetic macular edema (DME).DesignDouble-masked, 100-week, multicenter, active-controlled, randomized trials.MethodsSubjects were 1:1:1 to 3 mg/6 mg or 2 KESTREL (n = 566) 1:1 6 KITE 360). Brolucizumab groups received 5 loading doses every weeks (q6w) followed by 12-week (q12w) dosing, optional adjustment 8 (q8w) if disease activity was identified at predefined assessment visits; 4 (q4w) fixed q8w dosing....
Spectral-domain optical coherence tomography (SD-OCT) enables high-resolution analysis of retinal layers and previously unseen hyperreflective dots (HRD). HRD morphological characteristics, evolution, possible origin prognostic value are discussed.We conducted a prospective study 100 patients with exudative age-related macular degeneration (AMD), who were treated followed up monthly imaging examinations. Statistical correlations between visual acuity (VA) pre-/post- treatment characteristics...
To analyze choroidal changes associated with reticular pseudodrusen by indocyanine green angiography (ICGA) and enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT).Twenty-two consecutive patients (22 eyes) pseudodrusen, without medium/large drusen, underwent ICGA EDI OCT. Twenty-one age- sex-matched subjects (21 early age-related macular degeneration (AMD), also OCT.Mean age of AMD was 82.5 ± 0.9 79.3 4.4 years age, respectively (P = 0.9), 59.0% 76.2% were...
In Brief Purpose: To describe the appearance of acute syphilitic posterior placoid chorioretinitis, a rare ocular manifestation syphilis, on spectral domain optical coherence tomography (SD OCT) both before and after treatment. Methods: Ophthalmic examination imaging studies 30 eyes 19 confirmed cases were analyzed at time presentation each follow-up visit. Patients with SD OCT fluorescein angiography presentation, least three documented visits initiation therapy, included in study. Standard...
To assess the safety and efficacy of different doses RTH258 applied as single intravitreal administration compared with ranibizumab 0.5 mg in patients neovascular age-related macular degeneration (AMD).Six-month, phase 1/2, prospective, multicenter, double-masked, randomized, ascending single-dose, active-controlled, parallel-group study.A total 194 treatment-naive patients, aged ≥50 years, primary subfoveal choroidal neovascularization secondary to AMD.Patients received a injection (n =...
To investigate the multimodal morphological and functional characteristics of treatment-naïve "quiescent" choroidal neovascularization (CNV) secondary to AMD.Eleven patients with CNV that consecutively presented over a 6-month period, underwent assessment (including indocyanine green angiography [ICGA], spectral-domain optical coherence tomography [SD-OCT], microperimetry, preferential hyperacuity perimeter [PHP]). For purpose this study, asymptomatic previously untreated CNVs showing...