A5064387995- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Magnetic confinement fusion research
- Fusion materials and technologies
- Optical Imaging and Spectroscopy Techniques
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- melanin and skin pigmentation
- Superconducting Materials and Applications
- Optical Coherence Tomography Applications
- Intraocular Surgery and Lenses
- Particle accelerators and beam dynamics
- Visual perception and processing mechanisms
- Ocular and Laser Science Research
- Cerebral Venous Sinus Thrombosis
- Medical Image Segmentation Techniques
- Neural dynamics and brain function
- Nuclear Materials and Properties
- Ophthalmology and Visual Impairment Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Complement system in diseases
- Neural and Behavioral Psychology Studies
New York Eye and Ear Infirmary
2018-2025
Icahn School of Medicine at Mount Sinai
2018-2025
Columbia University
2009-2024
New York University
2008-2024
Mount Sinai Hospital
2019-2021
Hunter College
2020
Culham Science Centre
2001-2019
NYU Langone Health
2013-2017
Culham Centre for Fusion Energy
1992-2017
Indiana University School of Medicine
2016
Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in elderly developed countries. Our previous studies implicated activation complement formation drusen, hallmark lesion AMD. Here, we show that factor H (HF1), major inhibitor alternative pathway, accumulates within drusen and synthesized by retinal pigmented epithelium. Because linkage analyses identified chromosome 1q25-32, which harbors gene ( HF1 / CFH ), as an AMD susceptibility locus, analyzed...
Advanced age-related macular degeneration (AMD) is the leading cause of late onset blindness. We present results a genome-wide association study 979 advanced AMD cases and 1,709 controls using Affymetrix 6.0 platform with replication in seven additional cohorts (totaling 5,789 unrelated 4,234 controls). also comprehensive analysis copy-number variations polymorphisms for AMD. Our discovery data implicated between variant hepatic lipase gene (LIPC) high-density lipoprotein cholesterol (HDL)...
Detection of vascular bifurcations is a challenging task in multimodal retinal image registration. Existing algorithms based on usually fail correctly aligning poor quality pairs. To solve this problem, we propose novel highly distinctive local feature descriptor named partial intensity invariant (PIIFD) and describe robust automatic registration framework Harris-PIIFD. PIIFD to rotation, partially intensity, affine transformation, viewpoint/perspective change. Our Harris-PIIFD consists four...
JET underwent a transformation from full carbon-dominated tokamak to fully metallic device with beryllium in the main chamber and tungsten divertor. This material combination is foreseen for activated phase of ITER. The ITER-Like Wall (ILW) experiment at shall demonstrate plasma compatibility walls reduction fuel retention. We report on set experiments (Ip = 2.0 MA, Bt 2.0–2.4 T, δ 0.2–0.4) different confinement conditions global gas balance analysis demonstrating strong long-term retention...
Purpose.: Lipofuscin (LF) accumulation within RPE cells is considered pathogenic in AMD. To test whether LF contributes to cell loss aging and provide a cellular basis for fundus autofluorescence (AF) we created maps of human number histologic AF. Methods.: Retinal pigment epithelium–Bruch's membrane flat mounts were prepared from 20 donor eyes (10 ≤ 51 10 > 80 years; postmortem: ≤4.2 hours; no retinal pathologies), preserving foveal position. Phalloidin-binding cytoskeleton LF-AF (488-nm...
To evaluate the feasibility and reliability of a standardized approach for quantitative measurements fundus autofluorescence (AF) in images obtained with confocal scanning laser ophthalmoscope (cSLO).AF (30°) were acquired 34 normal subjects (age range, 20-55 years) two different cSLOs (488-nm excitation) equipped an internal fluorescent reference to account variable power detector sensitivity. The gray levels (GLs) each image calibrated reference, zero GL, magnification, give quantified...
To quantify fundus autofluorescence (qAF) in patients with recessive Stargardt disease (STGD1).A total of 42 STGD1 (ages: 7-52 years) at least one confirmed disease-associated ABCA4 mutation were studied. Fundus AF images (488-nm excitation) acquired a confocal scanning laser ophthalmoscope equipped an internal fluorescent reference to account for variable power and detector sensitivity. The gray levels (GLs) each image calibrated the reference, zero GL, magnification, normative optical...
To evaluate geographic atrophy (GA) progression in eyes with dry AMD and to determine factors related GA expansion, notably reticular pseudodrusen (RPD), also known as subretinal drusenoid deposits (SDD) or macular disease (RMD).This was a retrospective cohort study of patients who were diagnosed at least one eye imaged sequential fundus autofluorescence (FAF) and/or near infrared reflectance (NIR-R) imaging. Images analyzed for the presence within region. Geographic measured fields modified...
Fundus autofluorescence was quantified (qAF) in subjects with healthy retinae using a standardized approach. The objective to establish normative data and identify factors that influence the accumulation of RPE lipofuscin and/or modulate observed AF signal fundus images.AF images were acquired from 277 (age range: 5-60 years) by employing Spectralis confocal scanning laser ophthalmoscope (cSLO; 488-nm excitation; 30°) equipped an internal fluorescent reference. For each image, mean gray...
To seek pathways of retinal pigment epithelium (RPE) fate in age-related macular degeneration via a morphology grading system; provide nomenclature, visualization targets, and metrics for clinical imaging model systems.Donor eyes with geographic atrophy (GA) or choroidal neovascularization (CNV) one GA eye previous spectral-domain optical coherence tomography (SDOCT) were processed histology, photodocumented, annotated at predefined locations. Retinal epithelial cells contained...
To improve the understanding of Stargardt disease by comparing structural changes seen on spectral domain optical coherence tomography (SD-OCT) to those visible fundus autofluorescence (FAF).
Disconjugate eye movements have been associated with traumatic brain injury since ancient times. Ocular motility dysfunction may be present in up to 90% of patients concussion or blast injury. We developed an algorithm for tracking which the Cartesian coordinates right and left pupils are tracked over 200 sec compared each other as a subject watches short film clip moving inside aperture on computer screen. prospectively 64 normal healthy noninjured control subjects findings 75 trauma either...
Purpose.: To describe, illustrate, and account for two cell types plausibly derived from RPE in geographic atrophy (GA) choroidal neovascularization (CNV) of AMD, using melanosomes, lipofuscin, basal laminar deposit (BLamD) as anatomical markers. Methods.: Human donor eyes with GA (n = 13) or CNV 39) were histologically processed, photodocumented, analyzed frequencies occurrence. We defined cells containing spindle-shaped melanosomes internal to lamina BLamD, if present, Bruch's membrane...
In this paper, we propose a novel classification model for automatically identifying individuals with age-related macular degeneration (AMD) or Diabetic Macular Edema (DME) using retinal features from Spectral Domain Optical Coherence Tomography (SD-OCT) images. Our method uses such as the thickness of retina and individual layers, volume pathologies drusen hyper-reflective intra-retinal spots. We extract automatically, ten clinically important by segmenting SD-OCT images purposes. The...
Purpose: To build and validate artificial intelligence (AI)-based models for AMD screening predicting late dry wet progression within 1 2 years. Methods: The dataset of the Age-related Eye Disease Study (AREDS) was used to train our prediction model. External validation performed on Nutritional Treatment-2 (NAT-2) study. First Step: An ensemble deep learning methods trained validated 116,875 color fundus photos from 4139 participants in AREDS study classify them as no, early, intermediate,...
purpose. To assess the relationships of drusen, pigment, and focally increased autofluorescence (FIAF) reticular pattern hypoautofluorescence, to distinguish combined photographic AF characteristics early, atrophic, high-risk fellow eyes in AMD. methods. In a retrospective interinstitutional clinical study, color photograph pairs 221 were examined: 166 83 patients with bilateral large, soft without geographic atrophy (GA), 55 unilateral choroidal neovascularization (CNV). Forty-two (one eye...