A5063498672- Retinal Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Traffic and Road Safety
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Older Adults Driving Studies
- Injury Epidemiology and Prevention
- Trauma and Emergency Care Studies
- Atherosclerosis and Cardiovascular Diseases
- Automotive and Human Injury Biomechanics
- Urban Transport and Accessibility
- Shoulder Injury and Treatment
- Pelvic and Acetabular Injuries
- Bone fractures and treatments
- Hip and Femur Fractures
- Cardiac Arrest and Resuscitation
- Orthopedic Surgery and Rehabilitation
- Retinal and Optic Conditions
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Traumatic Ocular and Foreign Body Injuries
- Burn Injury Management and Outcomes
- T-cell and B-cell Immunology
- Orthopedic Infections and Treatments
University of Alabama at Birmingham
2016-2025
Geriatric Research Education and Clinical Center
2015-2024
St. Vincent's Birmingham
2010-2024
Children's of Alabama
2016-2024
University of Alabama
2012-2023
Hughston Clinic
2022-2023
Alabama Department of Public Health
1999-2023
Florida International University
2023
Community Link
2023
Palmetto General Hospital
2023
The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria in order to improve clinical relevance, meet stringent methodology requirements, incorporate new knowledge regarding immunology SLE.The were derived from a set 702 expert-rated patient scenarios. Recursive partitioning was used derive an initial rule that simplified refined based on SLICC physician...
In patients with systemic lupus erythematosus (SLE), hydroxychloroquine prevents disease flares and damage accrual facilitates the response to mycophenolate mofetil in those renal involvement. A study was undertaken determine whether also exerts a protective effect on survival.Patients SLE from multiethnic LUMINA (LUpus MInorities: NAture vs nurture) cohort were studied. case-control performed within context of this which deceased (cases) matched for duration (within 6 months) alive...
OBJECTIVES: To evaluate the relationship between performance‐based risk factors and subsequent at‐fault motor vehicle collision (MVC) involvement in a cohort of older drivers. DESIGN: Prospective study. SETTING: Motor Vehicle Administration (MVA) field sites Maryland. PARTICIPANTS: Of 4,173 drivers invited to participate study, 2,114 individuals aged 55 96 agreed do so. These analyses focus on 1,910 recruited through MVA sites. MEASUREMENTS: Gross Impairment Screening Battery, which included...
Injuries to the posterolateral corner of knee are disabling. Despite improved understanding this group tendons and ligaments, best surgical treatment an unstable is not clear.Surgical repair acute tears has outcomes that as good those from reconstruction combined with early motion rehabilitation protocol.Cohort study; Level evidence, 2.Sixty-three patients 64 were included in study, 39 repairs 25 reconstructions using modified 2-tailed technique. Patients evaluated clinical KT-2000...
Abstract Objective To examine whether hydroxychloroquine (HCQ) usage is associated with a reduced risk of damage accrual in patients systemic lupus erythematosus (SLE). Methods Patients (n = 518) meeting the American College Rheumatology criteria for diagnosis SLE and ≤5 years disease duration at study entry were followed up annually. Socioeconomic, demographic, clinical, serologic manifestations as well activity (by Systemic Lupus Activity Measure [SLAM]) International Collaborating Clinics...
The objective of this study is to examine the clinical features and outcomes patients with systemic lupus erythematosus (SLE) whose disease began in adolescence [juvenile-onset SLE (jSLE)] compared adult-onset [adult-onset (aSLE)] from a large multiethnic cohort. Systemic African-American, Caucasian, or Hispanic ethnicity ≥1 year follow-up were studied two groups: jSLE (diagnosed at ≤18 years); aSLE 19–50 years; matched for gender duration enrolment). Sociodemographic data, manifestations,...
To characterize the morphology, prevalence, and topography of subretinal drusenoid deposits, a candidate histological correlate reticular pseudodrusen, with reference to basal linear deposit (BlinD), specific lesion age-related macular degeneration, propose biogenesis model for both lesion.
Acute kidney injury (AKI) independently predicts mortality in children and adults. Our understanding of the epidemiology AKI very LBW (VLBW) infants is limited to retrospective studies. After adjustment for demographics, comorbidities, interventions, with have decreased survival compared those without AKI. The study was conducted regional quaternary care NICU University Alabama at Birmingham. VLBW were followed prospectively classified into a serum creatinine (SCr)-based classification...
Although management of warfarin is challenging for patients with chronic kidney disease (CKD), no prospective studies have compared response to among minimal, moderate, and severe CKD. This secondary analysis a cohort 578 evaluated the influence function on dosage, anticoagulation control, risk hemorrhagic complications. We adjusted all multivariable regression proportional hazard analyses clinical genetic factors. Patients CKD (estimated GFR <30 ml/min per 1.73 kg/m2) required significantly...
Abstract Objective To assess whether hydroxychloroquine can delay renal damage development in lupus nephritis patients. Methods Lupus patients (n = 256) from the LUpus MInorities, NAture versus nurture study 635), a multiethnic cohort of African Americans, Hispanics, and Caucasians, age ≥16 years with disease duration ≤5 at baseline (T0) were studied. Renal was defined using Systemic International Collaborating Clinics Damage Index (≥1 following lasting least 6 months: estimated/measured...
<h3>Background</h3> Rett syndrome (RTT), a neurodevelopmental disorder that primarily affects girls, is characterised by period of apparently normal development until 6–18 months age when motor and communication abilities regress. More than 95% individuals with RTT have mutations in methyl-CpG-binding protein 2 (MECP2), whose product modulates gene transcription. Surprisingly, although the caused single gene, disease severity affected can be quite variable. To explore source this phenotypic...
Background: In the prehospital environment, failure of medical providers to recognize latent physiologic derangement in patients with compensated shock may risk undertriage. We hypothesized that index (SI; heart rate divided by systolic blood pressure [SBP]), when used setting, could facilitate identification such patients. The objective this study was assess association between SI and massive transfusion (MT) relatively normotensive blunt trauma Methods: Admissions a Level I center January...
This study provides further evidence from a national sample to generalize the relationship between depression and vision loss adults across age spectrum. Better recognition of among people reporting reduced ability perform routine activities daily living due is warranted.To estimate, in survey US 20 years or older, prevalence visual function those with acuity impairment. The has not been reported nationally representative adults. Previous studies have limited specific cohorts predominantly...
Purpose.: Lipofuscin (LF) accumulation within RPE cells is considered pathogenic in AMD. To test whether LF contributes to cell loss aging and provide a cellular basis for fundus autofluorescence (AF) we created maps of human number histologic AF. Methods.: Retinal pigment epithelium–Bruch's membrane flat mounts were prepared from 20 donor eyes (10 ≤ 51 10 > 80 years; postmortem: ≤4.2 hours; no retinal pathologies), preserving foveal position. Phalloidin-binding cytoskeleton LF-AF (488-nm...
Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, hypertrophic response to PRT variable, and this may be due inflammation susceptibility. Metformin reduces inflammation, so we hypothesized that metformin would augment in healthy women men aged 65 older. In a randomized, double-blind trial, participants received 1,700 mg/day (N = 46) or placebo 48) throughout study, all subjects performed 14 weeks of...
The purpose of this study was to determine the cumulative incidence lupus nephritis (LN) and factors predictive its occurrencein a multiethnic systemic erythematosus (SLE) cohort. We studied 353 SLE patients as de” ned by American College Rheumatology (ACR) criteria (65 Hispanics, 93 African-Americans 91 Caucasians). First, we determined LN in all patients. Next, predictors for those with occurring after diagnosis. dependent variable, LN, by: (1) A renal biopsy demonstrating World Health...
Older drivers have elevated crash rates and are more likely to be injured or die if they a crash. Medical conditions medications been hypothesized as determinants of involvement. This population-based case-control study sought identify medical associated with risk at-fault crashes among older drivers. A total 901 aged 65 years were selected in 1996 from Alabama Department Public Safety driving records: 244 involved crashes; 182 not 475 enrolled. Information on demographic factors, chronic...
To determine the features associated with mortality in a multiethnic US cohort of patients systemic lupus erythematosus (SLE) within 5 years study onset.Socioeconomic and demographic (age, gender, ethnicity, marital status, education, occupation, poverty, health-related behaviors [drinking, smoking, exercising]), clinical immunologic (disease duration, disease onset type, activity according to Systemic Lupus Activity Measure [SLAM], damage International Collaborating Clinics [SLICC] Damage...
Abstract Objective To determine the baseline (time 0) risk factors associated with subsequent occurrence of vascular events in a multiethnic US cohort (LUMINA [LUpus MInorities: NAture versus nurture]) patients systemic lupus erythematosus (SLE). Methods Five hundred forty‐six LUMINA were assessed at time 0 for traditional and nontraditional (disease‐related) events. These defined as 1) cardiovascular (myocardial infarction and/or definite or classic angina undergoing procedure myocardial...
Aim: To determine and contrast the socioeconomic-demographic clinical features of patients with recent onset (5 y) systemic lupus erythematosus (SLE) from three ethnic groups, Hispanic, African-American Caucasian (H, AA, C). Subjects methods: SLE cases (American College Rheumatology criteria) (incident (n ‘ 56), prevalent 173)), were enrolled in a longitudinal study at The University Alabama Birmingham, Texas-Houston Health Science Center Texas Medical Branch Galveston....