A5082825997- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Peripheral Neuropathies and Disorders
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Liver Diseases and Immunity
- Renal Diseases and Glomerulopathies
- Spondyloarthritis Studies and Treatments
- Musculoskeletal pain and rehabilitation
- Vasculitis and related conditions
- Pharmacological Effects of Natural Compounds
- Acute Lymphoblastic Leukemia research
- Cytokine Signaling Pathways and Interactions
- Pregnancy and Medication Impact
- Drug-Induced Ocular Toxicity
- Inflammatory Myopathies and Dermatomyositis
- Diabetes and associated disorders
- Bone and Joint Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
University of Alabama at Birmingham
2016-2025
Universidad Peruana Cayetano Heredia
2015-2025
Hospital Nacional Cayetano Heredia
2024
University of North Carolina at Chapel Hill
1997-2024
University of Alabama
2000-2024
Emory University
2024
Convergence
2024
American College of Rheumatology
1990-2024
AID Atlanta
2024
Durham VA Medical Center
2024
The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria in order to improve clinical relevance, meet stringent methodology requirements, incorporate new knowledge regarding immunology SLE.The were derived from a set 702 expert-rated patient scenarios. Recursive partitioning was used derive an initial rule that simplified refined based on SLICC physician...
Abstract Clinical criteria for the classification of patients with hip pain associated osteoarthritis (OA) were developed through a multicenter study. Data from 201 who had experienced most days prior month analyzed. The comparison group other causes pain, such as rheumatoid arthritis or spondylarthropathy. Variables medical history, physical examination, laboratory tests, and radiographs used to develop different sets serve investigative purposes. Multivariate methods included traditional...
Abstract Objective To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. Methods Our sample was a multisite international SLE (23 centers, 9,547 patients). Deaths were ascertained by vital statistics registry linkage. Standardized ratio (SMR; of deaths observed to expected) estimates calculated for all and cause. The effects sex, age, duration, race, calendar‐year periods determined. Results overall SMR 2.4 (95% confidence interval 2.3–2.5)....
Abstract Clinical criteria for the classification of symptomatic idiopathic (primary) osteoarthritis (OA) hands were developed from data collected in a multi‐center study. Patients with OA compared group patients who had hand symptoms other causes, such as rheumatoid arthritis and spondylar‐thropathies. Variables medical history, physical examination, laboratory tests, radiographs analyzed. All pain, aching, or stiffness hands. classified having clinical if on examination there was hard...
Background: There is concern that exogenous female hormones may worsen disease activity in women with systemic lupus erythematosus (SLE). Objective: To evaluate the effect of hormone replacement therapy (HRT) on postmenopausal SLE. Design: Randomized, double-blind, placebo-controlled noninferiority trial conducted from March 1996 to June 2002. Setting: 16 university-affiliated rheumatology clinics or practices 11 U.S. states. Patients: 351 menopausal patients (mean age, 50 years) inactive...
Objective. To determine nephritis outcomes in a prospective multi-ethnic/racial SLE inception cohort. Methods. Patients the Systemic Lupus International Collaborating Clinics cohort (≤15 months of diagnosis) were assessed annually for estimated glomerular filtration rate (eGFR), proteinuria and end-stage renal disease (ESRD). Health-related quality life was measured by Short Form (36 questions) health survey questionnaire (SF-36) subscales, mental physical component summary scores. Results....
<h3>Background and aims</h3> We studied damage accrual factors determining development progression of in an international cohort systemic lupus erythematosus (SLE) patients. <h3>Methods</h3> The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort recruited patients within 15 months developing four or more 1997 American College Rheumatology (ACR) criteria for SLE; the SLICC/ACR index (SDI) was measured annually. assessed relative rates transition using maximum...
One hundred eighty-nine patients with rheumatoid arthritis were entered into a prospective, controlled, double-blind multicenter trial comparing placebo and methotrexate (MTX). ten completed 18 weeks of therapy. No remissions seen, but able to tolerate low-dose pulse MTX therapy significantly improved, compared receiving therapy, for all clinical variables measured, including joint pain/tenderness swelling counts, nodules, patient physician assessment disease activity. treatment demonstrated...
Abstract Objective Systemic lupus erythematosus (SLE) and nephritis (LN) disproportionately affect individuals who are members of racial/ethnic minority groups lower socioeconomic status (SES). This study was undertaken to investigate the epidemiology sociodemographics SLE LN in low‐income US Medicaid population. Methods We utilized Analytic eXtract data, with billing claims from 47 states Washington, DC, for 23.9 million ages 18–65 years were enrolled >3 months 2000–2004. Individuals (≥3...
Abstract Objective . To determine if regional cerebral blood flow (rCBF) in the left and right hemithalami or heads of caudate nucleus is abnormal women with fibromyalgia (FM). Methods Resting‐state rCBF 10 untreated FM 7 normal control was measured by single‐photon–emission computed tomography. Pain threshold levels at tender points also were assessed both controls. Results The significantly lower than controls ( P = 0.01, 0.003, 0.02, respectively). Compared controls, characterized...
Abstract Objective To examine whether hydroxychloroquine (HCQ) usage is associated with a reduced risk of damage accrual in patients systemic lupus erythematosus (SLE). Methods Patients (n = 518) meeting the American College Rheumatology criteria for diagnosis SLE and ≤5 years disease duration at study entry were followed up annually. Socioeconomic, demographic, clinical, serologic manifestations as well activity (by Systemic Lupus Activity Measure [SLAM]) International Collaborating Clinics...
Abstract Objective There is increasing evidence in support of an association between systemic lupus erythematosus (SLE) and malignancy, but earlier studies the could not be quantified precisely. The present study was undertaken to ascertain incidence cancer SLE patients, compared with that general population. Methods We assembled a multisite (23 centers) international cohort patients diagnosed as having SLE. Patients at each center were linked regional tumor registries determine occurrence....
Abstract Objective To assess whether hydroxychloroquine can delay renal damage development in lupus nephritis patients. Methods Lupus patients (n = 256) from the LUpus MInorities, NAture versus nurture study 635), a multiethnic cohort of African Americans, Hispanics, and Caucasians, age ≥16 years with disease duration ≤5 at baseline (T0) were studied. Renal was defined using Systemic International Collaborating Clinics Damage Index (≥1 following lasting least 6 months: estimated/measured...
Objectives To determine the frequency, accrual, attribution and outcome of neuropsychiatric (NP) events impact on quality life over 3 years in a large inception cohort patients with systemic lupus erythematosus (SLE). Methods The study was conducted by Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months SLE diagnosis. NP identified using American College Rheumatology case definitions, decision rules derived to proportion disease attributable SLE....
Objective To achieve consensus on a definition of remission in SLE (DORIS). Background Remission is the stated goal for both patient and caregiver, but has been lacking. Previously, an international task force consisting representatives medical specialists published framework such definition, without reaching final recommendation. Methods Several systematic literature reviews were performed specific research questions examined suitably chosen data sets. The findings discussed, reformulated...
<h3>Aim</h3> To determine characteristics associated with more severe outcomes in a global registry of people systemic lupus erythematosus (SLE) and COVID-19. <h3>Methods</h3> People SLE COVID-19 reported the Global Rheumatology Alliance from March 2020 to June 2021 were included. The ordinal outcome was defined as: (1) not hospitalised, (2) hospitalised no oxygenation, (3) any ventilation or oxygenation (4) death. A multivariable logistic regression model constructed assess relationship...
The purpose of this study was to determine the cumulative incidence lupus nephritis (LN) and factors predictive its occurrencein a multiethnic systemic erythematosus (SLE) cohort. We studied 353 SLE patients as de” ned by American College Rheumatology (ACR) criteria (65 Hispanics, 93 African-Americans 91 Caucasians). First, we determined LN in all patients. Next, predictors for those with occurring after diagnosis. dependent variable, LN, by: (1) A renal biopsy demonstrating World Health...
Abstract Objective To determine the baseline (time 0) risk factors associated with subsequent occurrence of vascular events in a multiethnic US cohort (LUMINA [LUpus MInorities: NAture versus nurture]) patients systemic lupus erythematosus (SLE). Methods Five hundred forty‐six LUMINA were assessed at time 0 for traditional and nontraditional (disease‐related) events. These defined as 1) cardiovascular (myocardial infarction and/or definite or classic angina undergoing procedure myocardial...
To describe the prevalence, characteristics, attribution, and clinical significance of neuropsychiatric (NP) events in an international inception cohort systemic lupus erythematosus (SLE) patients.The study was conducted by Systemic Lupus International Collaborating Clinics (SLICC). Patients were enrolled within 15 months fulfilling American College Rheumatology (ACR) SLE classification criteria. All NP a predefined enrollment window identified using ACR case definitions 19 syndromes....
Aim: To determine and contrast the socioeconomic-demographic clinical features of patients with recent onset (5 y) systemic lupus erythematosus (SLE) from three ethnic groups, Hispanic, African-American Caucasian (H, AA, C). Subjects methods: SLE cases (American College Rheumatology criteria) (incident (n ‘ 56), prevalent 173)), were enrolled in a longitudinal study at The University Alabama Birmingham, Texas-Houston Health Science Center Texas Medical Branch Galveston....
Background: Toxicity limits the use of methotrexate. Objective: To identify risk factors for methotrexate-induced lung injury in patients with rheumatoid arthritis. Design: Case-control study. Setting: One private and five academic rheumatology practices. Participants: Methotrexate recipients arthritis without injury. Measurements: Potential examined were sociodemographic lifestyle characteristics, medical history, clinical ancillary features treatment before methotrexate therapy,...