Laurent Arnaud
A5082120478- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Vasculitis and related conditions
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Renal Diseases and Glomerulopathies
- Histiocytic Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Otitis Media and Relapsing Polychondritis
- Eosinophilic Disorders and Syndromes
- Autoimmune and Inflammatory Disorders Research
- Hygrothermal properties of building materials
- Chronic Lymphocytic Leukemia Research
- Inflammatory Myopathies and Dermatomyositis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Vascular Anomalies and Treatments
- Cytokine Signaling Pathways and Interactions
- Sarcoidosis and Beryllium Toxicity Research
- Platelet Disorders and Treatments
- Psoriasis: Treatment and Pathogenesis
- SARS-CoV-2 and COVID-19 Research
- Pharmacological Effects of Natural Compounds
- Long-Term Effects of COVID-19
Inserm
2016-2025
Hôpitaux Universitaires de Strasbourg
2016-2025
Université de Strasbourg
2016-2025
Hôpital de la Timone
2013-2025
Université Gustave Eiffel
2025
Assistance Publique Hôpitaux de Marseille
2013-2024
Sorbonne Université
2009-2023
Hôpital d'Hautepierre
2017-2023
Alphabio
2023
Centre National de la Recherche Scientifique
2007-2023
Objectives To update the EULAR recommendations for management of systemic lupus erythematosus (SLE) based on emerging new evidence. Methods An international Task Force formed questions systematic literature reviews (January 2018–December 2022), followed by formulation and finalisation statements after a series meetings. A predefined voting process was applied to each overarching principle recommendation. Levels evidence strengths recommendation were assigned, participants finally provided...
Background Musculoskeletal (MSK) diseases are expected to have a growing impact worldwide. Objective To analyse the worldwide burden of MSK from 2000 2015. Methods Disability-adjusted life years (DALYs), which combines lost (YLLs) and lived with disability (YLDs), were extracted for 183 countries WHO Global Health Estimates Database. We analysed median proportion DALYS, YLLs YLDs (ICD-10: M00–M99) among 23 categories diseases. Mixed models built assess temporal changes. Results Worldwide,...
Purpose Histiocytoses are rare disorders with heterogeneous prognosis. BRAF V600E mutations have been observed in half of patients Langerhans cell histiocytosis (LCH) and 50% to 100% Erdheim-Chester disease (ECD) patients. We recently reported short-term efficacy a inhibitor (vemurafenib) three multisystemic ECD. Patients Methods Vemurafenib was given eight ECD CNS and/or cardiac involvement. All were refractory first-line treatment harbored mutation. Four also had LCH lesions. Positron...
Necrotizing autoimmune myopathy (NAM) is a group of acquired myopathies characterized by prominent myofiber necrosis with little or no muscle inflammation. Recently, researchers identified autoantibodies (aAb) against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in patients NAM, especially statin-exposed patients. Here we report what to our knowledge the first European cohort NAM.The serum 206 suspicion NAM was tested for detection anti-HMGCR aAb using an addressable laser bead...
Objective To achieve consensus on a definition of remission in SLE (DORIS). Background Remission is the stated goal for both patient and caregiver, but has been lacking. Previously, an international task force consisting representatives medical specialists published framework such definition, without reaching final recommendation. Methods Several systematic literature reviews were performed specific research questions examined suitably chosen data sets. The findings discussed, reformulated...
There is little known about the impact of SARS-CoV-2 on patients with inflammatory rheumatic and musculoskeletal diseases (iRMD). We examined epidemiological characteristics associated severe disease, then death. also compared mortality between hospitalised for COVID-19 without iRMD.Individuals suspected iRMD-COVID-19 were included in this French cohort. Logistic regression models adjusted age sex used to estimate ORs 95% CIs COVID-19. The most significant clinically relevant factors...
Abstract Coronavirus disease 2019 (COVID-19) has become one of the biggest public health challenges this century. Severe forms are associated with a thrombo-inflammatory state that can turn into thrombosis. Because tissue factor (TF) conveyed by extracellular vesicles (EVs) been implicated in thrombosis, we quantified EV-TF activity cohort hospitalized patients COVID-19 (n = 111) and evaluated its link inflammation, severity, thrombotic events. Patients severe were compared those who had...
Vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic (VEXAS) syndrome is an adult-onset disease associated with ubiquitin-like modifier-activating enzyme 1 (UBA1) mutations. We aimed to evaluate the efficacy safety of targeted therapies.