A5033347563- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Biosimilars and Bioanalytical Methods
- Chronic Lymphocytic Leukemia Research
- Bone and Joint Diseases
- Immunodeficiency and Autoimmune Disorders
- Pregnancy and Medication Impact
- Inflammatory Bowel Disease
- Cytokine Signaling Pathways and Interactions
- Bone health and osteoporosis research
- Monoclonal and Polyclonal Antibodies Research
- Bone Metabolism and Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Microscopic Colitis
- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal synovial abnormalities and treatments
- Peptidase Inhibition and Analysis
- Oral microbiology and periodontitis research
- Lymphoma Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Psoriasis: Treatment and Pathogenesis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammasome and immune disorders
Centre Hospitalier Universitaire de Saint-Étienne
2016-2025
Inserm
2016-2025
Université Jean Monnet
2014-2025
Hôpital Nord
2014-2025
Mines Saint-Étienne
2022-2025
Biologie, ingénierie et imagerie pour l'Ophtalmologie
2019-2024
Université Claude Bernard Lyon 1
2010-2023
Institute Cancer De La Loire Lucien Neuwirth
2016-2023
Bicêtre Hospital
2023
Hôpital Edouard Herriot
2005-2022
Data on the value of therapeutic drug monitoring infliximab (IFX) to predict mucosal healing (MH) in inflammatory bowel diseases (IBD) are scarce.All consecutive patients with IBD receiving ongoing IFX (5 mg/kg) treatment and developing secondary failure were enrolled a prospective study between June 2010 May 2011. trough levels, antibodies concentrations, C-reactive protein fecal calprotectin measured before optimization at week 8. A proctosigmoidoscopy was performed day first 8 all...
One-third of patients with rheumatoid arthritis show inadequate response to tumor necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists.To compare efficacy a non-TNF-targeted biologic (non-TNF) vs second anti-TNF drug for insufficient TNF inhibitor.A total 300 (conducted between 2009-2012) arthritis, persistent disease activity (disease score in 28 joints-erythrocyte sedimentation rate [DAS28-ESR] ≥ 3.2 [range, 0-9.3]) and an therapy were included...
Abstract Background Methotrexate (MTX) is the first‐line treatment for Rheumatoid Arthritis (RA), yet 30%–50% of RA patients develop resistance to MTX, which can manifest several years after initiation. Objective This study investigates relationship between erythrocyte methotrexate polyglutamates (MTX‐PGs) subtype concentrations and clinical disease activity in undergoing long‐term MTX treatment. Methods In this cross‐sectional study, on a stable dose subcutaneous were included. The protocol...
Summary Background Infliximab ( IFX ) combined with azathioprine AZA is more effective than monotherapy in inflammatory bowel disease IBD ). Aim To identify the optimal dose that required for efficacy when receiving combination therapy. Methods Patients durable remission on therapy were enrolled a 1‐year, open‐label, prospective trial after randomisation into three groups: steady (2‐2.5 mg/kg/day, n=28) vs down (dose was halved 1‐1.25 n=27) stopped (n=26). Primary endpoint failure defined as...
Background:Antibodies to infliximab [ATI] and trough levels [TRI] are associated with loss of response in inflammatory bowel diseases [IBD]. The best way predict [LOR] [IFX] is unknown.
To evaluate a possible association between wrist and periodontal destruction in rheumatoid arthritis, destruction, dry mouth, labial salivary gland biopsy the contribution of genetic factors (the shared epitope (SE) IL1B (+3954) or TNFA (-238 -308) gene polymorphisms).147 patients with arthritis were enrolled. Periodontal damage was defined according to Hugoson Jordan criteria on panoramic dental x rays. Typing for SE cytokine polymorphisms undertaken by enzyme linked oligosorbent assay....
Regulation of IL-6 transsignaling by the administration soluble gp130 (sgp130) receptor to capture IL-6/soluble IL-6R complex has shown promise for treatment rheumatoid arthritis (RA). However, enhancing endogenous sgp130 via alternative splicing gene not yet been tested. We found that epigallocatechin-3-gallate (EGCG), an anti-inflammatory compound in green tea, inhibits IL-1beta-induced production and RA synovial fibroblasts inducing mRNA, resulting enhanced production. Results from vivo...
The goal of the present study was to record changes in bone mineral density (BMD) and markers turnover patients with rheumatoid arthritis (RA) who were treated methotrexate combined (or not combined) infliximab. Included 90 RA required anti-TNF-α therapy infliximab because persistent active disease despite treatment methotrexate. historical control group included 99 at a time when yet available. Lumbar femoral neck BMD measured using dual energy X-ray absorptiometry baseline 1 year later....
<h3>Objectives</h3> A new high-resolution peripheral quantitative CT (HR-pQCT) system allows for in vivo assessment of bone microarchitecture and volumetric mineral density (vBMD) with an 82 µm isotropic resolution. With this device, the impairment was evaluated patients rheumatoid arthritis (RA) comparison healthy controls measured erosion volume at metacarpal heads (MCPs). <h3>Methods</h3> In cross-sectional study, reproducibility first assessed by 3 HR-pQCT exams repositioning 14 late RA...
Objective. The objective of this study was to identify predictors response and remission tocilizumab (TCZ) in RA patients seen daily routine clinical practice. Methods. efficacy TCZ evaluated after 12 24 weeks treatment by the European League Against Rheumatism (EULAR) criteria. Regression analysis performed association between or EULAR following characteristics: gender, age, current smokers, prior cardiovascular disease (CVD), 28-joint activity score (DAS28), CRP, RF ACPA positivity,...
Abstract Background The development of vitiligo during treatment with biological agents is an unusual event and only a few isolated cases have been reported. Objectives To describe the clinical characteristics evolution patients developing new‐onset following initiation agent for chronic inflammatory disease; also to report course pre‐existing under therapy. Methods This nationwide multicentre, retrospective study, carried out between July 2013 January 2015, describes large series 18...
Methotrexate (MTX) is a remarkable drug with key role in the management of rheumatoid arthritis (RA) at every stage its evolution. Its attributes include good overall efficacy for signs and symptoms, inhibition structural damage preservation function acceptable manageable safety, large dose-titratable range, options either an oral or parenteral route administration, currently unrivalled cost-effectiveness. It has place as monotherapy also anchor that can be safely used combination other...
<h3>Objectives</h3> Association between periodontal disease (PD) and rheumatoid arthritis (RA) has been extensively described, but direct evidence of causal involvement PD in RA is missing. We investigated the priming role oral <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) subsequent we assessed biomarkers bone resorption development rats. <h3>Methods</h3> Lewis rats were orally exposed to either <i>P. gingivalis</i>, <i>Prevotella intermedia</i> or control gel for 1 month then...
Objective. High-resolution peripheral quantitative computed tomography (HR-pQCT) sensitively detects erosions in rheumatoid arthritis (RA); however, nonpathological cortical bone disruptions are potentially misclassified as erosive. Our objectives were to set and test a definition for pathologic RA standardize reference landmarks measuring erosion size. Methods. HR-pQCT images of metacarpophalangeal joints control subjects used an iterative process achieve consensus on the landmarks....
Importance There are conflicting data on the association of antidrug antibodies with response to biologic disease–modifying antirheumatic drugs (bDMARDs) in rheumatoid arthritis (RA). Objective To analyze treatment for RA. Design, Setting, and Participants This cohort study analyzed from ABI-RA (Anti-Biopharmaceutical Immunization: Prediction Analysis Clinical Relevance Minimize Risk Immunization Rheumatoid Arthritis Patients) multicentric, open, prospective patients RA 27 recruiting centers...
<h3>Objectives:</h3> The use of biologicals such as infliximab has dramatically improved the treatment rheumatoid arthritis (RA). However, factors predictive therapeutic response need to be identified. A proteomic study was performed prior therapy identify a panel candidate protein biomarkers RA response. <h3>Methods:</h3> Plasma profiles 60 patients with (28 non-responders (as defined by American College Rheumatology 20% improvement criteria (ACR20)) negative and 32 responders (ACR70...
Generation 5 (G5) poly(amidoamide) (PAMAM) dendrimers are synthetic polymers that have been broadly applied as drug delivery carriers. Methotrexate (MTX), an anti-folate metabolite, has successfully used anti-inflammatory to treat rheumatoid arthritis (RA) in the clinic. In this study, we examine therapeutic efficacy of G5 PAMAM dendrimer methotrexate conjugates (G5-MTX) also folic acid (FA) conjugated G5-MTX (G5-FA-MTX) target inflammation-activated folate receptors overexpressing...
Objective. To assess the relationship between body mass index (BMI) and efficacy of tocilizumab (TCZ) in patients with rheumatoid arthritis (RA). Methods. We conducted a retrospective study 222 RA followed by 5 centers. The European League Against Rheumatism response was evaluated at 6 months. Univariate multivariate logistic regressions were performed. Results. No significant association BMI to TCZ months found after adjustment for potential confounding factors (adjusted OR 0.45, 95% CI...
Patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular (CV) disease. Adiponectin is involved in the metabolism glucose and lipids favourable effects on CV disease, especially its high molecular weight (HMW) isoform. Body composition changes are described RA various phenotypes including obesity. The tocilizumab serum adiponectin body composition, fat mass, patients not well determined.Patients active despite previous csDMARDs and/or bDMARDs who were naïve enrolled a...
Objective The role of YAP/TAZ, two transcriptional co-activators involved in several cancers, was investigated rheumatoid arthritis (RA). Methods Fibroblast like synoviocytes (FLS) from patients with RA or osteoarthritis were cultured 2D into 3D synovial organoids. Arthritis rat model (n=28) and colitis mouse (n=21) used. YAP/TAZ activity inhibited by verteporfin (VP). Multiple techniques used to assess gene and/or protein expression localization, cell phenotype (invasion, proliferation,...