A5072483210- Mycotoxins in Agriculture and Food
- Occupational exposure and asthma
- Animal Nutrition and Physiology
- Asthma and respiratory diseases
- Carcinogens and Genotoxicity Assessment
- Meat and Animal Product Quality
- Renal cell carcinoma treatment
- Indoor Air Quality and Microbial Exposure
- Autoimmune and Inflammatory Disorders
- Agricultural safety and regulations
- Contact Dermatitis and Allergies
- Lung Cancer Treatments and Mutations
- Sarcoidosis and Beryllium Toxicity Research
- Rheumatoid Arthritis Research and Therapies
- Cystic Fibrosis Research Advances
- Occupational and environmental lung diseases
- Genetic factors in colorectal cancer
- Systemic Lupus Erythematosus Research
- Respiratory and Cough-Related Research
- Systemic Sclerosis and Related Diseases
- Cancer Genomics and Diagnostics
- Multiple Sclerosis Research Studies
- Renal and related cancers
- Virus-based gene therapy research
- Brain Metastases and Treatment
Centre Hospitalier Universitaire de Saint-Étienne
2023-2025
Carol Davila University of Medicine and Pharmacy
2023
Clinical Emergency Hospital Bucharest
2023
Institute Cancer De La Loire Lucien Neuwirth
2023
Hôpital du Sacré-Cœur de Montréal
2017-2019
Hospital Universitario La Paz
2018
Hospital La Paz Institute for Health Research
2018
Hôtel-Dieu de Montréal
2016
Université de Montréal
2016
Hôpital Avicenne
2009-2014
Abstract Background Methotrexate (MTX) is the first‐line treatment for Rheumatoid Arthritis (RA), yet 30%–50% of RA patients develop resistance to MTX, which can manifest several years after initiation. Objective This study investigates relationship between erythrocyte methotrexate polyglutamates (MTX‐PGs) subtype concentrations and clinical disease activity in undergoing long‐term MTX treatment. Methods In this cross‐sectional study, on a stable dose subcutaneous were included. The protocol...
Approximately 10% of patients with non-small cell lung cancer (NSCLC) have brain metastases at the time diagnosis. When surgical resection is not possible, whole radiotherapy standard care, a cerebral response rate approximately 30%. We report our experience an upfront association carboplatin and pemetrexed (areas under curve, 5 500 mg/m2, respectively), every 3 weeks, in 30 presenting newly diagnosed NSCLC. Cerebral MRIs were performed 6–9 weeks. The radiologic rates assessed according to...
Patients with Cystic Fibrosis are subject to repeated respiratory tract infections, recent increasing isolation of unusual pathogens. Ralstonia species have lately been isolated at our institution, an organism historically frequently misidentified as Burkholderia or Pseudomonas. The prevalence spp. in cystic fibrosis populations has yet be determined, along its clinical implications. Seven patients out the 301 followed clinic had strains identified their tract. Most were multi-drug...
The 7th edition of TNM for renal cell carcinoma introduced a subdivision pT2 tumors at 10 cm cutoff. In the present multicenter study influence tumor size as well further clinical and histopathological parameters on cancer specific survival in patients with was evaluated.A total 670 consecutive (10.4%) 6,442 surgically treated all stages were pooled (mean followup 71.4 months). Tumors reclassified according to current classification, subdivided pT2a pT2b. Cancer analyzed using Kaplan-Meier...
Ochratoxin A (OTA) is a nephrotoxic/carcinogenic mycotoxin; produced by several Aspergillus - and Penicillium -strains. It also have hepatotoxic immunosupp ressive effect. The aim of the study was to evidentiate histological ultrastructural le sions kidney in an experimental ochratoxicos pattern broiler chickens from 1 st 21 day life.. Administration OA dose 1mg/ kg determined small degenerative lesions epithelial cells convoluted tubules; alternating with unchanged zone s after 7 th 14...
The "united airway disease" concept is based on the bidirectional interaction between asthma and rhinitis. aim of this study was to determine relationship upper diseases bronchial hyperresponsiveness (BHR), as well their association with fractional concentration exhaled nitric oxide (FeNO) atopy in patients persistent symptoms suggestive requiring methacholine challenge testing (MCT) confirm diagnosis.A cross-sectional prospective carried out adult asthma-like negative bronchodilator...
In 3 groups, each of 15 broiler chickens ochratoxine A (OTA) was given orally, in sunflower oil suspension, daily, for 21 days doses of: 5μg/kg b.w. group E1, 35 μg/kg E2 and 100μg/kg E3. Control (of chickens) received only oil. 5 from were killed after 7, 14 21st day the experiment. Skin samples taken head, chest, wings coccigian region gut mucosa prevealed duodenum, jejunum coecal tonsils. All prepared paraphin embeding stained with: HEA, PAS, PAS Alcian blue May Grunwald Giemsa lymphoid...
OBJECT: To investigate peritumoral edema and its prognostic factors in brain metastases of lung breast cancers, more specifically to evaluate the effect treatment with angiotensine-II (Ang2) inhibitors. This was shown a recent study display significant primary tumor edema. MATERIALS AND METHODS: We retrospectively reviewed medical files all patients newly diagnosed consulting our institution years 2012 2013. measured maximal diameter lesions DL (contrast enhancement) DE (diameter minus...
A 56-year-old woman presented to the emergency room after two weeks of experiencing progressive dyspnea and a dry cough.She had 35-year history Crohn's disease colectomy at 28 years age.She suffered recurrent episodes pouchitis, which, due infliximab, was in clinical remission.Two months starting treatment, she developed painful subcutaneous nodules on lower limbs around elbows, arthralgia knees, increasing fatigue, occasional fever.Her gastroenterologist discontinued anti-TNF treatment...
BackgroundMicrosatellites, also known as Short Tandem Repeats (STRs) are short (1-6 base pairs) repeating segments of DNA scattered throughout the human genome, accounting for approximately 3% it.Because their repeated structure, microsatellites have a predisposition high mutation rates.Microsatellite instability is molecular phenotype determined by defective mismatch repair system (1-3).Microsatellite occurs in about 15% gastrointestinal cancers, being associated with specific clinical,...